Laura Fedele

The 41st Cell Physiology Workshop will take place in Liverpool UK, from 17-28th August 2026. 🧪🔬🫀🧠🐌🦑

Sign-up below to register your interest in attending, and receive all the important details and updates. 👇🏼 #ionchannels #neuroskyence

If you try the parasympathetic protocol we would love to know how you get along- send me an email 📩

This was possible thanks to the support of @kingsioppn.bsky.social Early Career Award, joining expertise between @wolfsonsparc.bsky.social and @qmulwhri.bsky.social and super collaborative scientists @denklab.bsky.social @alit78.bsky.social @nevesjf.bsky.social

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, ...

Happy to share our new preprint
doi.org/10.1101/2025...
We present a protocol to generate Parasympathetic neurons from hiPSC. They express key parasympathetic/autonomic markers, #ephys features and respond to nicotine. They can also form functional connections with hiPSC-atrial cardiomyocytes.

Group photo from CPW2025 in the teaching lab

#CPW2025 is now over, but we're already planning for #CPW2026 🦑🧠🫀🔬

To receive updates & find out when applications open for next year's Cell Physiology Workshop in Liverpool, go here:
forms.office.com/e/PTh5qMvmUM

Please share the link with your electrophysiology trainees. 🙂

Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...

Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!

www.biorxiv.org/content/10.1...

@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal

Cannot believe that week one of the @cpw-liverpool.bsky.social is nearly over! A brilliant week so far! Thank you to everyone who has contributed so far, especially to the @biologists.bsky.social for their funding of our 40th workshop!

The @cpw-liverpool.bsky.social has completed the first week; another brilliant first week with an outstanding cohort of participants!

Looking forward to week 2…after a few nights sleep!

Some scenes from this year's Work Experience event, where we hosted a group of A-Level students for a week and gave them a variety of demonstrations, hands-on experiments, and lectures.

I can never get bored of recording action potentials from my iPSC sympathetic neurons and the RMP was -70mV 😍 #patchclamp #ephys

Honoured to have presented at the super cool Ephys Club⚡😎👩‍🔬 and thank you for all the constructive comments!

Many thanks to @theorah.bsky.social who did a wonderful job as our comic artist and bringing Professor SPaRC to life!

Sympathetic neurons can modify the intrinsic structural and functional properties of human pluripotent stem cell‐derived cardiomyocytes Abstract figure legend Schematic representation of the key differences between innervated and non-innervated hiPSC-CMs. Innervated hiPSC-CMs (right) exhibit several improved characteristics compared ...

physoc.onlinelibrary.wiley.com/doi/10.1113/...
#neuroscience #neuroskyence #cardiac #stemcell

Super happy to share our work just published in @jphysiol.bsky.social
led by Neda Mohammadi and a amaxing work by all the authors!
We show that sympathetic neurons can enhance the maturity of stem cell derived cardiomyocytes structurally and functionally- exciting data for neurocardiac models!

Congrats to the team for their ongoing commitment to the IoPPN Research Culture Fund in their successful running of the CommuniTEA event on Guy's Campus! @lau-fed.bsky.social @juliavw.bsky.social ☕️ #CommuniTEA
Learn more here: www.kcl.ac.uk/news/seven-p...

These research models trump cards look so much fun!! Amazing work @comeflywithjo.bsky.social !!!
#StemCells #STEMoutreach #neuroskyence