Basler Lab

Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks Nature Communications - Pseudomonas aeruginosa H1-T6SS delivers effectors in response to exogenous T6SS attacks. In this study, a CRISPRi screen identifies pathways involved in P. aeruginosa...

Big congrats to @atejadaarranz.bsky.social and co-authors on this paper showing novel insights into the resistance to #T6SS effectors and an unexpected link to antibiotic resistance!

Thanks @nccr-antiresist.bsky.social for funding and supporting the collaboration with the Jenal lab!

rdcu.be/eShqI

Update to BacFighT6, with presets for easy exploration of complex behaviors:
sites.google.com/view/bacfight6

Try "battle royale" preset where prey (blue) produce capsule, attackers (red) move towards prey and feed on it, defenders (orange) retaliate!

Took a while to eliminate the reds!

The type VI secretion system and associated effector proteins - Nature Reviews Microbiology In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...

Happy to share our latest T6SS review:
nature.com/articles/s41...

Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!

The prey (blue) multiply, don't move and produce capsule (purple). The predators (red) move towards prey and attack non-kin. They divide only if they lyse prey. The defenders (orange) move randomly and defend themselves by retaliation (divide if they lyse a cell). Who wins?

Check out the NotebookLM powered interactive Q&A: sites.google.com/view/bacfigh...
This is based on the scientific literature and the simulation code. Literature is cited in the help and the documentation. Extremely helpful!

Major update to BacFighT6: sites.google.com/view/bacfigh...
Simulate the role of motility/chemotaxis, capsule production, activation by autoinducers, contact dependent killing, kin-exclusion, foraging and more. Long simulations, extensive data import/export and analysis. Interactive Q&A!

To make our research more approachable, I used #Gemini to develop (mostly by #vibecoding) a simulation of #T6SS mediated bacterial interactions. I hope that you'll have as much fun as I have with this and that you'll learn something new!
sites.google.com/view/bacfigh...

The Role of Uncharacterised Genes in the Activity of the Acinetobacter baylyi Type VI Secretion System - Inspiration - Schweizer Jugend forscht Chemie  |  Biochemie  |  Medizin   William Blättler, 2005 [...]

Happy to help William with his high school graduation project:
inspiration.sjf.ch/the-role-of-...

youtu.be/u0d72T9rRQg?...

Congratulations!

Thanks to @biozentrum.unibas.ch and @nccr-antiresist.bsky.social for support!

YouTube video by Swiss Nanoscience Institute Bacterial attack only as defense

Thank you, Katrin, for a great news article:

Damaged but not defeated: Bacteria use nano-spearguns to retaliate against attacks
biozentrum.unibas.ch/news/detail/...

And the Swiss Nanoscience Institute for producing this video summary:
youtu.be/0uOVdcOy3vQ?...

Poke bacteria with a sharp needle and they poke back in just a few seconds!
Congratulations to Mitchell (and others) for this analysis of Pseudomonas #T6SS assembly in response to membrane damage!
Collaboration with Rod Lim's lab @biozentrum.unibas.ch

www.science.org/doi/10.1126/...

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until May 18, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibasel.ch
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