Ted Price

Home | Center for Advanced Pain Studies | UTD CAPS is aggressively pursuing lines of research aimed at alleviating suffering from pain and improving the lives of people with chronic pain and migraine.

We are interested in acute and chronic pain but chronic pain is our focus. More info on what we do is at our Center website paincenter.utdallas.edu

Thank you so much!!

I also want to point out that this work was entirely funded by NIH through the HEAL Initiative. The future of HEAL is somewhat uncertain right now and I hope this paper will play a small role in convincing folks that this work is important and will have an impact on pain science and treatment.

Thanks for reading my thread! Doing this work has been a dream come true for me. I am incredibly grateful to Katherin Gabriel and @oliviadavis.bsky.social for making this amazing journey possible and to the organ donors and their family for the gift of knowledge they have given us.

Finally, we compared mice to humans and saw conservation of most neuronal types, but divergences in neuronal proportions and transcriptomes, in particular for cell surface receptors. If you want to do drug discovery, these details matter!!

We then went to town on the glial populations where we identified some pretty profound sex differences. We did not note sex differences in neurons, but the identification of male and female specific glial populations for astrocytes, microglia, and oligodendrocytes could have important functions.

And, of course, we did the same with the ventral horn, giving confidence in our identification of motor neuron pools.

We used this information to create detailed maps of the locations of cell types in the dorsal horn. This gives great insight into sensory/nociceptive circuits in the human dorsal horn with a resolution that has not been seen before at this scale.

Of course, we also care about non-neuronal cells and the spatial arrangement of all of these cell types so we used Xenium spatial transcriptomics to map the locations of these cell types using gene markers from our single nucleus work. Our custom panel led to many important insights.

We did the same thing for ventral horn neurons (we microdissected the dorsal horn from the ventral horn to have clear sequencing) and were able to clearly delineate motor neuron populations.

We mapped dorsal horn neurons using single nucleus sequencing and developed detailed transcriptomes for subtypes which we named using a nomenclature system based on work done at the Allen Brain Atlas.

We did single nucleus sequencing and Xenium @10xgenomics.bsky.social spatial transcriptomics on male and female spinal cords from organ donor recovered tissues in collaboration with Southwest Transplant Alliance. We started this work about 5 years ago. We optimized and optimized and optimized.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Also huge props to @allanhpool.bsky.social
and his lab at UTSW for helping optimise our single nuc prep and looking for species differences between human and mice.
This paper builds on the foundation already set and increases our understanding of human spinal cord at an even higher resolution.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social

www.biorxiv.org/content/10.1...

We have a great Department and UTD is still a great place to work!

We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693

The best

TrkA and its downstream signaling via MAPK (I think it’s mostly MNKs) remains a great target for pain in OA!

wonder if we could convince them to chant "Fire Nico"?

Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. I’ll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience!
@tedpricethepainguy.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

A test of nerves in diabetic peripheral neuropathy

@dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...

Director of Rutgers Center on Research in Pain and Pain Therapeutics - Piscataway, New Jersey job with Rutgers University/RUTGERS BRAIN HEALTH INSTITUTE | 675694 The ideal candidate will be a leader in pain research with a strong, federally funded research program

HUGE opportunity at Rutgers: jobs.sciencecareers.org/job/675694/d.... They already have such a dynamic pain group there, and such a great history... really an amazing opportunity.

Do type I interferons increase pain perception or reduce it?

@uenzastiga.bsky.social @tedpricethepainguy.bsky.social & team interrogate human pain-sensing neurons, revealing IFN-I induces excitability & TRPV1 sensitization via MNK1/2 signaling: insight.jci.org/articles/vie...

Faculty position in Neuroscience at UT Austin: apply.interfolio.com/175280 A great Department and an exceptional scientific community in Austin and across the UT System.

Also agree

Not only not normal, but totally unprecedented in my lifetime.

YouTube video by AnaBios Mechanisms of Neuropathic Pain: Lessons from Human DRG & Spinal Cord Studies by Dr. Ted Price

The webinar that I did for Anabios is now available on youtube: www.youtube.com/watch?v=llj2...

and here is some more evidence of mRNA transport in human DRG axons, just officially published today in @jci.org by @dianatavf.bsky.social www.jci.org/articles/vie...