Google at its peak was basically the best information retrieval system in human history and they and every competitor decided going from there to “you didn’t want answers you wanted half-assed auto-complete 80%-wrong hallucinations” in a few years was the right idea

Phospholipid Transport Across the Bacterial Periplasm Through the Envelope-spanning Bridge YhdP The outer membrane of Gram-negative bacteria provides a formidable barrier, essential for both pathogenesis and antimicrobial resistance. Biogenesis o…

A very - ahem - groovy talk by @georgiaisom.bsky.social: the protein YhdP spans the E. coli periplasm and transports phospholipids to the OM via a hydrophobic groove along its length. Impressive mix of computational & wet lab work www.sciencedirect.com/science/arti...

Kate Willett pass her viva yesterday, congrats Dr Willett! Huge thanks to @robfagan.bsky.social @ @jeremykeown.bsky.social

I think young Professor Tame had a good time with us @warwicklifesci.bsky.social curtesy of an IAS professorial fellowship and is now of on the second leg in Rome. Thanks to my lab for making home feel so welcome. I may have to visit him in Rome, just to make sure he’s ok of course…

JB Editor's Choice: Anderson, Khursigara et al. review the role of peptidoglycomics in understanding the structure and function of peptidoglycan.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...

Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...

30 years on since @YSBL_York who would have thought these two old gits would find themselves in a lab together again!

Looking for a PhD? 🚀 MIBTP projects are out lots to explore!
🔬 #Bacteria • #AMR • #Interdisciplinary • FUN!
My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry.
warwick.ac.uk/fac/cross_fa...

Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉

I joined School of Life Sciences 3 months ago and these guys have been so welcoming. Gibbet Hill Rovers making it feel like being apart of a community instantly. Thanks to @davidroper2.bsky.social for helping me get involved. Looking forward to season 3!

People get special things engraved…. We got cryo-EM pucks engraved.
Now time to make some samples @jeremykeown.bsky.social

Great opportunity to do a PhD with Giusy and co in Glasgow!

Anyone else had a circuit board blow on a Sorval ultracentrifuge in the recent past?

Two PhD theses submitted to day from @warwicklifesci.bsky.social Kate Willett from my lab and Becca Bailey from @pstansfeld.bsky.social. Supervisor of one, internal examiner for another!

Dual transposon sequencing profiles the genetic interaction landscape in bacteria Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform...

New from Chris Sham at NUS www.science.org/doi/10.1126/...

Lovely trip back to @UniOfYork to the carbohydrate group meeting of the @RoySocChem. Old friends and familiar places

It’s been my honour and privilege to co-organise the Great Wall Symposium with @ivo-boneca.bsky.social for the past 14 years, roll on 2027 more news soon.

And that’s a wrap on the Great Wall Symposium 2025!
Roll on 2027, venue to be confirmed shortly …

Natural product-derived compounds in clinical trials and drug approvals Covering: January 2014–June 2025. Previous review: Natural Product Reports, 2014, 31, 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery ...

Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...

#naturalproducts #antibiotic #amr #drugdiscovery #drug

Simplifying access to MRC applicant-led funding We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.

ICYMI: Simplifying access to MRC applicant-led funding #MRC #AcademicSky

And we are off! Professor Tame of Yokohama City University starts his first experiment as part of his sabbatical thanks to an IAS fellowship here

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

How it’s started, how it’s going …

Have fun in Paris!

That or you are not sharing that chimkin sandwich in your hand…

Yep, totally agree.

I have no issue with constructive criticism or different viewpoints and opinions, which is a very instructive part of the writting process, but don’t reject a paper on a single myopic issue because you have fundamentally no understanding of what you are being critical of

I recently submitted a paper to a journal and got some of the most ridiculous negative feedback I’ve ever seen citing lack of rigour in experiments and writing. Without going into details, I responded pointing out a lack of rigour in the referees comments to begin with.

Get well soon, you have horses to ride!!!

Dear Bluesky, some good news to brighten your day! We are recruiting for the Director of the Centre for Population and Disease Genomics!! I would be grateful if you could share across your networks! uq.wd3.myworkdayjobs.com/uqcareers/jo...