Edward Wallace

I am learning a lot from this debate about the last eukaryotic common ancestor. It's thought-provoking to have competing hypotheses and perspectives argued out there in the open.

Here, the two arguments are internally consistent, yet different conclusions... so where's the wrong assumption?

Today's @gautamdey.bsky.social seminar on Evolutionary Cell Biology is mind-blowing in so many ways.

Dinoflagellates don't have histones!?!?!

And BEAUTIFUL microscopy.

We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...

Congratulations!

Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!

Indeed it makes no sense and wastes a lot of peoples' time.

This. Named researcher positions do not have to be advertised.

Ok - sorry I misunderstood and glad the PI is on your side.

IMO the PI could have dealt with it without worrying you. But the strategies that lots of us are suggesting are good.

MRC writing a letter to HR, or, PI directly contacting a senior person in HR, also may help.

Yeah. The "PI said I didn't have to work any more on the project for now" gives a poor impression though.

IMO, after you've sought advice an appropriate next step could be a mediated meeting with the PI. Mediators could include an ethics officer, a union rep, HR person, or dept. chair. Take advice on how to prepare for the meeting to achieve your goals. 6/

More important advice: your department or institute should have a ethics office, ethics officer, or dean of research, who can advise you.

The UK research integrity office has material on how to approach situations like this, and an email advice service. They may be able to help.
ukrio.org
5/

Ugh...

How to blow the Whistle and still have a career afterwards - Science and Engineering Ethics Filing charges of scientific misconduct can be a risky and dangerous endeavor. This article presents rules of conduct to follow when considering whether to report perceived misconduct, and a set of st...

You're in the right so fighting is likely to get you *something* - maybe the job you fought for, maybe a payout.

DOCUMENT EVERYTHING.

I recommend the paper by CK Gunsalus, "How to blow the Whistle and still have a career afterwards." doi.org/10.1007/s119...

Lastly, good luck.

4/

You could also consider speaking to your local union representative, especially if you are a member.

HR may be helpful.

The MRC grants advisers may be helpful.

However, in difficult situations like this if it can be resolved more locally that can be better. 3/

I recommend that you start by finding local senior folks who can take your corner. There should be a local "postdoc champion" or "postdoc advisor" who could help advocate for you. You may have another mentor or collaborator who can help. If you know the department chair, talk to them!!! 2/

Hi Maria. Sorry to hear about your situation. Your post is being shared around now as an example of "how others should not behave" and the situation reflects very badly on the PI.

If you did this work for the grant and are named on it, you should be offered the job. You have some options 1/

This seems like you would have good advice for the original poster.

Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...

Jane Richardson stands next to the lectern and in front of the title slide of her talk. 30 October, 2025.

Slide with the follow text: “The zen of model anomalies. Correct most of them. Treasure the meaningful valid few. Live serenely with the rest!”

Wonderful talk by the legendary Jane Richardson today on validation of #cryoEM and #xray protein structures as part of the S2C2 modeling and validation workshop at SLAC. I continue to be amazed by how deeply she understands macromolecular geometry.

We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....

We had a great fungal minisymposium yesterday
@edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together.

Next one January or February TBA: Email me to be added to the email list!

Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.

Translon: a single term for translated regions. #Translation @natmethods.nature.com

Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited

Antifungal exposure can enhance Candida glabrata pathogenesis Azole antifungal drugs directly inhibit lanosterol 14-α-demethylase and indirectly affect the expression of metabolic, transmembrane transporter, and cell wall organization genes in fungal pathogens. ...

New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh.
www.biorxiv.org/content/10.1...

Oh I am!

Thanks Richard, could you repost on how to get involved in affiliates helping the bioRxiv team?

(Also: it me, involved in multiple bioRxiv submissions pre-holiday that are adding to your backlog.)

bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏

V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation.

Oh multiple authors! Next level!