The Lancet Child & Adolescent Health

Our October issue is out - featuring biomarkers for sudden unexpected death in epilepsy, developments in the diagnosis of multiple sclerosis, climate change & brain health and much more!

Check it out here: tinyurl.com/3z5u36e7

#Neurology #BrainHealth

Girl with healthy meal on tray at school cafeteria. Copyright: Westend61/Getty Images.

With global obesity prevalence surpassing that of underweight among children & adolescents, harmful food environments & weak policies threaten lifelong health.

What can we do to address this global health crisis?

Find out more in our latest Editorial: tinyurl.com/3cnvctkv

Published in The Lancet @thelancet.com:

The future of type 1 #diabetes therapy www.thelancet.com/journals/lan...
#T1D
#OpenAccess

#MedSky #EndoSky

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle... In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed agent, ATG, in a low and sa...

In The Lancet @thelancet.com:
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 #diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial www.thelancet.com/journals/lan... #T1D

Join our Lancet Webinar on the importance of analysing, reporting, and interpreting data according to sex and gender. Copyright: Elsevier Ltd.

Join Zoë Mullan and other Lancet Group editors to learn more about the SAGER guidelines for sex- and gender-based analyses, explore real research examples, and gain practical tips for responding to the guidelines.

📅 21 October, 2pm BST
👉 Register: hubs.li/Q03FQ_6l0

Our October issue is live!

Including research on #vaccination in #rheumatoidarthritis and
#hydroxychloroquine during #pregnancy, two Reviews on #VEXAS, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

Quote from a correspondence published in The Lancet entitled 'Improving survival and reducing suffering for children with NCDs.' Quote reads: [The Fourth High-level Meeting of the UN General Assembly6 on the prevention and control of NCDs] is an opportunity to galvanise a global movement for children with chronic and catastrophic diseases, especially cancers and sickle cell disease, and ensure they are no longer left behind.

NCDs affect more than 2 billion children and adolescents each year.

In a new letter, authors call for a shift from generalised #NCD strategies to specific, child-centred commitments backed by:
➡️ Global frameworks
➡️ Measurable targets
➡️ Long-term investment

🔗 tinyurl.com/3ryn7w74

Read our October issue!

Featuring a trial testing moxidectin for lymphatic filariasis, bedaquiline resistance and tuberculosis outcomes, and a recombinant influenza vaccine for children.

www.thelancet.com/issue/S1473-...

Long-term sequelae in survivors of high-risk neuroblastoma: the price of success Until 2000, neuroblastoma was one of the deadliest tumours of childhood, with probabilities of long-term survival not exceeding 30%. In the past two decades, children with high-risk neuroblastoma have...

Read the linked Comment by Maria Antonietta De Ioris & Franco Locatelli: Long-term sequelae in survivors of high-risk neuroblastoma: the price of success

www.thelancet.com/journals/lan...

Late effects after high-risk neuroblastoma (LEAHRN): a multicentre, cross-sectional cohort study from the Children's Oncology Group Survivors of high-risk neuroblastoma treated with modern therapies demonstrated a substantial burden of late effects, providing crucial information for future care and clinical trial design.

New online: Late effects after high-risk #neuroblastoma (LEAHRN): a multicentre, cross-sectional cohort study from the Children's Oncology Group

bit.ly/48zRnpK

@danafarber.bsky.social @sickkidsto.bsky.social @childrensphila.bsky.social @stjuderesearch.bsky.social @cityofhope.bsky.social

Explore the new data on the global burden of #cancer in children, adolescents, & young adults

"Childhood cancers occurring in the 0–14 year age range comprised 1·4% of all cancer cases and 1·0% of all cancer deaths globally in 2023, but 3·2% of all cancer DALYs"

Childhood Cancer Awareness Month

Surviving and thriving after childhood cancer Without treatment, childhood cancer is fatal. However, in regions and settings with access to safe and effective therapies and supportive care, it is eminently survivable. But survival comes at the co...

Our editorial, published in advance of our November issue, discusses challenges around quality of life in #childhoodcancer in the context of global child & adolescent health

#free to read

www.thelancet.com/journals/lan...

Childhood Cancer Awareness Month #PedSky #OncSky

Join our webinar on the importance of analysing, reporting, and interpreting data according to sex and gender on Tues, Oct 21, 2025 at 2pm BST/9am EDT. The Lancet Webinars. Copyright: Elsevier Ltd.

📢 Join our webinar on sex and gender reporting in research

📅 Tues, 21 October, 2pm BST
👉 Register: hubs.li/Q03FQ_6l0

Our editors will guide you through our requirements for sex- and gender-based analyses, and share practical tips and examples of well-analysed research

Safety, tolerability, and protective efficacy of a radiation-attenuated, whole sporozoite malaria vaccine in children in Gabon: a randomised, double-blind, placebo-controlled, phase 2 trial PfSPZ Vaccine is well tolerated and safe, but it did not prevent P falciparum infection in children in Gabon. Whether presumptive treatment during immunisation or more potent PfSPZ vaccines can establ...

New Research:

Safety, tolerability, and protective efficacy of a radiation-attenuated, whole sporozoite malaria vaccine in children in Gabon: a randomised, double-blind, placebo-controlled, phase 2 trial

www.thelancet.com/journals/lan...

All clinical research and review in child & adolescent health across @thelancet.com group conveniently in one place 👇

www.thelancet.com/collections/...

#PedSky

Parent-focused behavioural interventions for the prevention of early childhood obesity (TOPCHILD): a systematic review and individual participant data meta-analysis These findings indicate that examined parent-focused behavioural interventions are insufficient to prevent obesity at age 24 months (±6 months). This evidence highlights a need to re-think childhood o...

Parent-focused programs insufficient to prevent obesity in toddlers, finds meta-analysis; authors call for a re-think of childhood obesity prevention approaches.

Explore the research ▶️ tinyurl.com/4mxaaypx

Childhood tuberculosis: robust funding and integrated solutions needed now The USA has led the world in global health activities, providing US$278 billion to low-income and middle-income countries (LMICs) for health since 2000.1 Despite being only 0·3% of US Government spend...

Linked Commentary by Anna Maria Mandalakasa & colleagues: Childhood tuberculosis: robust funding and integrated solutions needed now

www.thelancet.com/journals/lan...

Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025–34: a mathematical modelling study Without actions to restore discontinued services, cuts to health aid for tuberculosis and HIV programmes could result in millions of additional childhood tuberculosis cases and deaths in low-income an...

New research from Nicolas Menzies & colleagues: Potential #paediatric #tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025–34: a mathematical modelling study

www.thelancet.com/journals/lan...

#PedSky #InternationalAid

Figure showing the immunopathogenesis of Shigella infection in the colon. MAMPs=microbe-associated molecular patterns. DAMPs=damage-associated molecular patterns. NK=natural killer. Adapted from Schnupf and Sansonetti. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Shigellosis is the most common cause of invasive bloody diarrhoea in children younger than 5 years.

The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.

Find out more ▶️ tinyurl.com/ard69t83

Parent-focused behavioural interventions for the prevention of early childhood obesity (TOPCHILD): a systematic review and individual participant data meta-analysis These findings indicate that examined parent-focused behavioural interventions are insufficient to prevent obesity at age 24 months (±6 months). This evidence highlights a need to re-think childhood o...

💡A new systematic review & meta-analysis in @thelancet.com concludes that "parent-focused behavioural interventions are insufficient to prevent obesity at age 24 months" suggesting that childhood obesity prevention approaches "need a re-think"

www.thelancet.com/journals/lan...

#MedSky #PedSky

Beyond sepsis awareness: why some children still fall through the cracks In 2014, when William Mead unexpectedly died of sepsis at just 12 months old, his mother, Melissa, transformed her grief into a relentless mission. She stepped into a world she had never imagined: end...

In advance of #WorldSepsisDay, a Reflection from Akash Deep & Melissa Mead

www.thelancet.com/journals/lan...

#SepsisAwarenessMonth

🚨Our Sept issue is live - 25 years! thelancet.com/journals/lan...

📊Articles #renalcellcarcinoma, #prostatecancer, #meningioma, #thymiccarcinoma, & #colorectalcancer

Reviews: 📰 ESTRO and ASTRO plus endorsed guidelines on vol delineation & 📰 Common Sense Oncology and EORTC on reporting QoL data

European and North American guidelines for treating irritable bowel syndrome and functional abdominal pain in childhood: a guide for health-care professionals Abdominal pain-related disorders of gut–brain interaction (AP-DGBI; including irritable bowel syndrome, functional abdominal pain—not otherwise specified, abdominal migraine, and functional dyspepsia)...

*NEW* Health Policy from Morris Gordon & colleagues: European and North American guidelines for treating irritable bowel syndrome and functional abdominal pain in childhood: a guide for health-care professionals

www.thelancet.com/journals/lan...

#MedSky #PedSky #GastroSky

NEW RESEARCH—Serum biomarkers associated with baricitinib response in patients with juvenile idiopathic arthritis: a post-hoc analysis of the phase 3 JUVE-BASIS trial bit.ly/4nrPIqK #JIA #Medsky #Rheumsky

Our October Issue is now online, featuring prediabetes remission, obesity, type 1 diabetes, biased GLP-1 receptor agonists, type 2 diabetes, prolactin-secreting adenomas, malnutrition-related diabetes, food system, NCDs & much more www.thelancet.com/journals/lan...

#MedSky #EndoSky #OncSky

Comparison of predictive tools for management of paediatric mild #TBI: a prospective cohort study

Despite assumed similarities of these predictive tools, there are important differences in diagnostic performance, practical application and clinical impact

www.thelancet.com/journals/ecl...
#MedSky

Cover of The Lancet Microbe's September issue with a "Light micrograph of a lung sample from an AIDS patient showing cysts of Pneumocystis [jirovecii]".

Our September issue is now online:

www.thelancet.com/journals/lan...

Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #HIV #Pneumocystis #tuberculosis #TB #gonorrhoea #Citrobacter #AMR #Salmonella

#IDSky #ClinMicro #OA

The October issue of @LancetGastroHep is now available at thelancet.com/gastrohep!

Includes content on #AI, colonoscopy, inflammatory bowel disease, MASLD, viral hepatitis, and more...

#GastroSky #IBDSky #HepSky #MedSky

Paediatric malnutrition in Gaza amid conflict: an urgent health crisis Since late 2023, Gaza has endured a protracted armed conflict with restricted humanitarian access, which has ultimately transformed its chronic food insecurity into an acute famine emergency. On Aug 1...

In a new letter, Yara Ashour & colleagues call for urgent prioritisation within the global humanitarian and public health agenda to address paediatric malnutrition in Gaza: www.thelancet.com/journals/lan...

Oct 2025 Volume 9 Number 10 p685-752 Cover image by Jhoan Mosquera Suarez, age 6 years. A rainbow and apple tree overlook mountains and sea.

Our October 2025 issue is now live with content on #consent in #neonatal #clinicaltrials, growth trajectories in #twins, an #RCT on #CPAP delivery in #preterm #infants, & more

Read the full issue here👉 bit.ly/3JDzc8t

#MedSky #PedSky