Stéphane Lemaire's Avatar

Stéphane Lemaire

@slemaire75.bsky.social

Director & Co-founder Paris Biofoundry at Sorbonne University Chief Innovation Officer & Co-founder Biomemory Team leader at LCQSB Research Director CNRS

119 Followers  |  113 Following  |  1 Posts  |  Joined: 28.11.2024
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Posts by Stéphane Lemaire (@slemaire75.bsky.social)

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🌍It was a great honor to host #BriardoLlorente from the #AustralianGenomeFoundry at the #ParisBiofoundry!

We exchanged insights, experiences and collaboration opportunities, and toured the Sorbonne Foundry to showcase our cutting-edge facilities.
@arccoesb.bsky.social @parisbiofoundry.bsky.social

15.05.2025 13:28 — 👍 5    🔁 2    💬 0    📌 0
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Design of a Modular Inducible Circuit for Pulsatile Population
Control of Engineered Bacteria
doi.org/10.1101/2025...

05.05.2025 13:37 — 👍 1    🔁 2    💬 1    📌 0
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🚀 The #DNAfoundry at @parisbiofoundry.bsky.social is now fully assembled!

A new hub for #highthroughput DNA design, #assembly & #sequencing, accelerating #SyntheticBiology research.🔬✨

@cnrs.fr @sorbonne-universite.fr @genopole.bsky.social @institutcurie.bsky.social @inrae-france.bsky.social

05.05.2025 13:15 — 👍 7    🔁 3    💬 0    📌 0
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📢 The SC-DNA 2025 registration deadline is extended to May 31st!

Register now to attend the Storage & Computing with DNA 2025 conference (June 19-21, @sorbonne-universite.fr)! 📷

🔗 premc.org/storage-comp...

#DNADataStorage #ComputingWithDNA #SCDNA2025

23.04.2025 08:32 — 👍 1    🔁 1    💬 0    📌 0
Examples of the pre-survey outputs.

Examples of the pre-survey outputs.

Introducing SAVEMONEY, AKA ‘Simple Algorithm for Very Efficient Multiplexing of Oxford Nanopore Experiments for You’

A new tool offering a faster, cheaper computational approach to democratise whole-plasmid sequencing.
buff.ly/ov7YumB

14.04.2025 10:02 — 👍 12    🔁 6    💬 1    📌 1
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💾 🧬 Arrange your summer travel now to these great conferences: tinyurl.com/597uthcu
• Storage & Computing with DNA, June 19-21, Paris
• New Trends in DNA-Based Data Storage, June 3-6, Prague
• Symposium on Chemistry of Nucleic Acid Components, June 8-13, Český Krumlov

27.03.2025 17:34 — 👍 3    🔁 1    💬 2    📌 0

Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective!
Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.

27.03.2025 18:45 — 👍 87    🔁 55    💬 1    📌 2

Interested in photosynthetic organisms? Looking for a space to focus on research and kick-start your journey as a group leader? We’d love for you to join us. We offer an incredibly competitive package—on par with about 2 ERC grants for 8 years—and a collaborative environment unlike anywhere else 1/2

27.03.2025 22:07 — 👍 11    🔁 13    💬 1    📌 0
Image: Activated and unliganded RuBisCO protein from Spinach. Credit: Taylor, T.C., Andersson, I./ Wikimedia Commons

Image: Activated and unliganded RuBisCO protein from Spinach. Credit: Taylor, T.C., Andersson, I./ Wikimedia Commons

Rubisco enzyme is responsible for capturing CO2 from the atmosphere, crucial for photosynthesis. Recent research has mapped mutant Rubisco molecules which could revolutionize plant CO2 assimilation & adapt to future climates

buff.ly/OLYpwtX v @innovativegenomics.bsky.social #PlantScience #Science

21.03.2025 18:24 — 👍 6    🔁 3    💬 0    📌 0
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Timed batch inputs unlock significantly higher yields for enzymatic cascades
www.researchsquare.com/article/rs-5...

09.03.2025 08:22 — 👍 3    🔁 2    💬 0    📌 0
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Case Study: Applying automation expertise to support new technology development The Earlham Institute was awarded a Flexible Talent Mobility Award (FTMA) from BBSRC – designed to facilitate short-term exchanges between academic or industrial institutions – to place two…

💬 “It’s important to recognise the importance of miniaturisation in #genomics for the future."

Two automation specialists from the Earlham Institute recently worked with the application development team at @sptlabtech.bsky.social on the development of firefly®.

@drkarimgharbi.bsky.social

08.03.2025 13:00 — 👍 2    🔁 1    💬 0    📌 0
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🚨 Deadline Extension for Storage and Computing with DNA 2025 🚨
🔹 New abstract submission deadline: March 21, 2025
🔹 New registration deadline: April 21, 2025
premc.org/storage-comp...

@dnadatastorage.bsky.social @biomemory.com
@sorbonne-universite.fr @slemaire75.bsky.social
@pcrozet.bsky.social

03.03.2025 15:46 — 👍 3    🔁 3    💬 0    📌 0
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Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus | Science www.science.org/doi/10.1126/...

08.02.2025 12:43 — 👍 1    🔁 1    💬 0    📌 0
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Design and regulation of engineered bacteria for environmental release - Nature Microbiology Chemla et al. review the release of bacteria into the environment and propose engineering strategies to help improve performance and reduce risk.

www.nature.com/articles/s41...

05.02.2025 14:11 — 👍 1    🔁 1    💬 0    📌 0
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Yesterday, we had the pleasure at @leibnizinm.bsky.social to hear Dr Lemaire from the @parisbiofoundry.bsky.social on how DNA can be used for data storage 🧪 and the amazing capabilities of the biofoindry! Such a joy 🙂 Here my sketchnotes✏️

05.02.2025 16:37 — 👍 11    🔁 4    💬 0    📌 0
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"Chlorella Vulgaris is a freshwater microalga rich in protein, lipids, carbohydrates, vitamins, and minerals. Unlike conventional agriculture, which requires extensive land and water resources, it can be cultivated sustainably with a minimal footprint.

www.sciencedaily.com/releases/202...

02.02.2025 01:53 — 👍 1    🔁 1    💬 0    📌 0
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📢 Big news at the Paris Biofoundry!

We’ve welcomed the Echo 650T Series Acoustic Liquid Handler from #BeckmanCoulter .

With contact-free acoustic transfers down to 2.5 nL, this game-changing tool enhances assay miniaturization and boosts efficiency for #DNAassembly, #DrugDiscovery and more!

29.01.2025 16:04 — 👍 3    🔁 1    💬 0    📌 0
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📢 Big news at the Paris Biofoundry!

We’ve just received the Orbitrap Ascend Tribrid Mass Spectrometer (MultiOmics model). A game-changer for #Proteomics, #Metabolomics & #MultiOmics research, it’s here to empower innovation in synthetic biology & biotherapies.

@thermofishersci.bsky.social

06.12.2024 17:04 — 👍 7    🔁 2    💬 0    📌 0
Job opening for the Head of the Max Planck DNA Biofoundry for automated DNA assembly. Applications are invited for a full time scientist position to head a Core Facility for DNA assembly / DNA Biofoundry at the Max Planck Institute (MPI) for Terrestrial Microbiology in Marburg, Germany (http://www.mpi-marburg.mpg.de). Further information can be obtained from https://www.mpi-marburg.mpg.de/148510/e_open_positions.

Job opening for the Head of the Max Planck DNA Biofoundry for automated DNA assembly. Applications are invited for a full time scientist position to head a Core Facility for DNA assembly / DNA Biofoundry at the Max Planck Institute (MPI) for Terrestrial Microbiology in Marburg, Germany (http://www.mpi-marburg.mpg.de). Further information can be obtained from https://www.mpi-marburg.mpg.de/148510/e_open_positions.

Exciting opportunity! Max Planck Institute for Terrestrial Microbiology is looking for a Head of the DNA-Biofoundry MaxGENESYS. Join us in vibrant #Marburg - apply by 15 February 2025. #ScienceJobs #SyntheticBiology #Biofoundry @maxplanck.de

20.01.2025 14:44 — 👍 10    🔁 15    💬 0    📌 4
From: "Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation" Matt et al (2016)

Text:
"Fig. 1. Volvox carteri body plan and cell types. Center, an adult vegetative Volvox spheroid with two distinct cell types: ~2000 small, flagellated somatic cells (right inset) and ~16 large, aflagellate germ cells called gonidia (left inset). Somatic cells are on the outer surface of the spheroid with flagella oriented towards the exterior. Gonidia are just beneath the somatic cell layer in the posterior hemisphere. All cells are embedded within a clear, compartmentalized extracellular matrix. Anterior (A) and posterior (P) poles of the spheroid are labeled."

From: "Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation" Matt et al (2016) Text: "Fig. 1. Volvox carteri body plan and cell types. Center, an adult vegetative Volvox spheroid with two distinct cell types: ~2000 small, flagellated somatic cells (right inset) and ~16 large, aflagellate germ cells called gonidia (left inset). Somatic cells are on the outer surface of the spheroid with flagella oriented towards the exterior. Gonidia are just beneath the somatic cell layer in the posterior hemisphere. All cells are embedded within a clear, compartmentalized extracellular matrix. Anterior (A) and posterior (P) poles of the spheroid are labeled."

Unlike our cells, each of which becomes terminally differentiated (eventually), Volvox cells retain the ability to nimbly shift functions.

But also unlike single-celled relatives like Chlamydomonas, they don't have to undergo major changes to go from somatic (body) to gonidial (reproductive) forms.

25.01.2025 22:00 — 👍 12    🔁 1    💬 1    📌 0
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Cell-Free Synthesis System: An Accessible Platform from Biosensing to Biomanufacturing
doi.org/10.1016/j.mi...

02.02.2025 11:57 — 👍 1    🔁 2    💬 0    📌 0
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Randomizing the human genome by engineering recombination between repeat elements We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

Randomizing the human genome by engineering recombination between repeat elements | Science www.science.org/doi/10.1126/...

02.02.2025 12:26 — 👍 1    🔁 1    💬 0    📌 0
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Cell-Free PURE System: Evolution and Achievements The cell-free protein synthesis (CFPS) system, as a technical core of synthetic biology, can simulate the transcription and translation process in an …

Cell-Free PURE System: Evolution and Achievements

www.sciencedirect.com/science/arti...

#CellFree #CFPS #SynBio

11.01.2025 12:05 — 👍 1    🔁 3    💬 0    📌 0
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When Bacteria Go Gel: The Sticky Science of Microbial Cables - SynBioBeta

🦠 When Bacteria Go Gel! 🦠
Researchers discovered that in polymer-rich environments, like mucus in cystic fibrosis, bacteria form tangled “cables”- a living Jell-O effect!

read more: www.synbiobeta.com/read/when-ba...

#ScienceFacts #Microbiology #Caltech

29.01.2025 00:25 — 👍 1    🔁 1    💬 0    📌 0
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Out today in Separation & Purification Technology journal. Sebastian Overmans, PhD, Himanshu Mishra, and Adair Gallo Jr. show how to functionalize microparticles and use them as adsorbants for terpene extraction from microbial cultures.

Illustration Heno Hwang
www.sciencedirect.com/science/arti...

28.01.2025 08:10 — 👍 2    🔁 2    💬 0    📌 0
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells Smith et al. engineered a “turn on” fluorescent biosensor (dubbed “PancACe”) for acetyl-CoA from a fusion of the proteins PanZ and circularly permuted GFP. PancACe measures changes in acetyl-CoA level...

A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells: Cell Chemical Biology www.cell.com/cell-chemica...

28.01.2025 15:17 — 👍 15    🔁 4    💬 0    📌 1
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms.
https://buff.ly/40nMuKL

28.01.2025 09:21 — 👍 13    🔁 3    💬 0    📌 0
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LIFE FINDS A WAY!!!

www.sciencedirect.com/science/arti...

28.01.2025 22:36 — 👍 30    🔁 8    💬 2    📌 0
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A cyanobacterial screening platform for Rubisco mutant variants Rubisco is the main entry point of inorganic carbon into the biosphere and a central player in the global carbon system. Its relatively low catalytic constant as well as its tendency to also accept O2...

A collection of amazing Rubisco papers and preprints this week. Here's another!

www.biorxiv.org/content/10.1...

27.01.2025 03:27 — 👍 10    🔁 4    💬 0    📌 0