Jaison J Sequeira

Excited to share our new preprint on time-lagged F2-statistics, which informs about migration rates from ancient DNA data. Find a preprint here: https://www.biorxiv.org/content/10.64898/2026.03.12.710875v1

The work was driven by Giulio Isacchini and Oskar Hallatschek. Proud to be part of it! […]

@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs).

If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.

New preprint! with @a-solernunez.bsky.social

Rethinking a textbook example of human adaptation "AMY1 copy number evolution in light of demographic history"

Once population structure is accounted for, the classic starch–agriculture narrative becomes much less clear

www.biorxiv.org/content/10.6...

Congratulations Josué!

SPAAM Newsletter #8 Hello from the SPAAM Steering Committee in the New Year 2026!

We are excited to share with you the latest SPAAM Newsletter!
Inside, you’ll find: announcements, opportunities and publication highlights.
www.spaam-community.org/assets/media...
We hope you enjoy this edition!
#SPAAM #aDNA #Newsletter #paleogenomics #metagenomics

Interesting new multi-population aDNA selection scan from Colbran, Terhorst, Mathieson. Loci that are estimated to be under selection in one population also show enrichment in other populations, consistent with parallel or pre-split selection.

www.biorxiv.org/content/10.6...

Silenced genomes - Nature Medicine Projects worldwide push for more diverse genomic databases across Asia, Africa and the Americas.

www.nature.com/articles/s41...

Oh, look! A paper about the coolest piece of software I've ever built!

Abstract submission & Award applications for SMBE 2026 are now open!

Submit your research and apply for SMBE awards via the submission portal.
📝 Read more & submit here: smbe2026.org/abstracts

And symposium selection is now finalized!
👉 See all accepted symposia: smbe2026.org/programme

#SMBE2026

Ancient southern Africans took genetic evolution in a new direction An ancient, shared set of human-specific genes underwent changes in a geographically isolated population after around 300,000 years ago, scientists say.

The story about #ancientsouthernafricans in the #ScienceNews now: www.sciencenews.org/article/anci... #media #humanevolutionprogram

Precious high coverage genomes from Africa! Congratulations @cschlebu.bsky.social and team. Exciting times indeed.

Homo sapiens-specific evolution unveiled by ancient southern African genomes - Nature The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.

Our new ancient DNA paper has just been published!
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!

www.nature.com/articles/s41...

Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...

We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7

we made a tool!
ybyra is a lightweight, flexible Y-chromosome haplogroup caller. It is faster, easier to tune and more robust than other tools particularly for low-coverage or ancient DNA data. And it has lots of detailed output – including plots!

www.biorxiv.org/content/10.1...

Our special issue on popgen methods and software is on a roll with the second paper out! Looking forward to many exciting papers to come! Submission open until 15 January. www.pivotscipub.com/hpgg/special...

🚨 Reminder to send in your abstracts for the palaeogenomics conference in Stockholm! 🧬🦠🐕💃🏼

If your results are still preliminary, my tip is to keep the abstract broad rather than skip submitting altogether 😉

See the post below for the price estimate and looking forward to seeing you there 🥳! #aDNA

Thank you for sharing my story! More power to you and GHIST ⭐

🦴🧬🦴🧬🦴

Abstract submission is now open for the 1st International Conference on Palaeogenomics!

June 23–26 2026, in Stockholm.

Join researchers from across the field for 4 days and >100 talks (+ poster sessions)!

Submit abstracts here 👉
icp2026.palaeogenomics.org/abstracts/

Deadline: Nov 30th

Thank you very much for helping me experience all of this ❤️

Pre @gensocuk.bsky.social talk @crick.ac.uk by Svante Pääbo, and interesting thoughts on how to define a “modern” human. More tomorrow!

From Conference Attendee to Co-Author: The Journey I Never Expected F or years, I dreamed of it: standing in a room full of international scientists, sharing my research, and being a part of the global conv...

Check out my blog summarising my experience at the SMBE2024 conference. You can also learn about my recent work on the Proto-Dravidian ancestry component. @official-smbe.bsky.social @mitopr.bsky.social @mashaals.bsky.social @ryangutenkunst.bsky.social popgenworld.blogspot.com/2025/11/from...

@official-smbe.bsky.social @molbioevol.bsky.social

GHIST 2024: The First Genomic History Inference Strategies Tournament Abstract. Evaluating population genetic inference methods is challenging due to the complexity of evolutionary histories, potential model misspecification,

I am happy to share our manuscript summarising the outcome of GHIST2024 (ghist.bio). With so many statistical tools and software, population genetics research seems easy. But every case is different. The approaches used vary! doi.org/10.1093/molbev/msaf257 @ryangutenkunst.bsky.social

Tracing the Roots of the Koraga: The Discovery of a Lost Ancestor in India's Genetic Story I n the lush, coastal districts of South India, the Koraga people have lived for generations on the margins. Historically labelled as "untou...

Our article describing the "Proto-Dravidian" ancestry has been published in the European Journal of Human Genetics @ejhg-journal.bsky.social Here is a simplified summary of the scientific findings. #protodravidian #ivc #ancientcivilisation popgenworld.blogspot.com/2025/10/trac...

Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

We are migrants. We move to survive. All of us! Political boundaries do not define who we are, who we will be.

news.harvard.edu/gazette/stor...

Adaptations to water stress and pastoralism in the Turkana of northwest Kenya The Turkana pastoralists of Kenya inhabit arid, water-limited environments and rely largely on livestock for subsistence. Working with Turkana communities, we sequenced 367 whole genomes and identifie...

Adaptations to water stress and pastoralism in the Turkana of northwest Kenya | Science www.science.org/doi/10.1126/...

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications Multi-ancestry GWASs enhance discovery in diverse populations, but optimal methods remain debated. Using theory, simulations, and analyses from the UK Biobank and All of Us, we show that pooled analys...

Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...

SPAAM Summer School (2025): Introduction to Ancient Metagenomics Share your videos with friends, family, and the world

Interested in learning more about how researchers analyze ancient DNA? Here you can find the free lectures from the SPAAM Summer School 2025 - Introduction to Ancient Metagenomics: tinyurl.com/3u9mhmd2
Slides: tinyurl.com/mkfrvru4
Feel free to ask questions in the comments!
#ancientDNA #SPAAM

Polygenic prediction of human complex traits using ancient DNA Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article,…

Nice review of polygenic prediction of traits based on ancient DNA, by @mathiesoniain.bsky.social

www.sciencedirect.com/science/arti...

A very special paper where we did something NEW! 🔥combining a large genetic dataset 🧬, a large linguistic dataset 💬, and Bayesian multilevel logistic regressions 📈, counting the effects of areal contact (geographic constrains) 🌎. Genetic admixture explains higher levels of linguistic exchanges...