Jaison J Sequeira

"Churning" the past for answers. An interesting chapter on samudramanthana and the connection between milk and snakes in Indo-European heritage. #IndoEuropean #IndoIranian #rigveda
stockholmuniversitypress.se/reader/chapt...

I'm so proud to see this paper published! Hopefully, it can inspire a positive change in the field of #palaeoproteomics, through open science and researchers working together instead of against each other. Huge thanks and congrats to all coauthors! 🎉

The spatiotemporal distribution of human pathogens in ancient Eurasia - Nature Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and zoonotic pathogens…

#MetagenomicsMonday Analysis of aDNA from 1313 ancient human remains spanning 37k years revealed that the rise of infectious diseases coincided with animal domestication around 65k years ago, with disease spread intensifying during pastoralist migrations.
www.nature.com/articles/s41...

A SNP panel for co-analysis of capture and shotgun ancient DNA data Advances in technology have decreased the cost of generating genetic variation data from ancient people, resulting in exponentially increasing numbers of individuals with whole genome data. However, e...

www.biorxiv.org/content/10.1...

An illustration of a DNA strand surrounded by faces. Artist: Saurabh Singh.

New research from Priya Moorjani's lab offers insights into India’s genomic legacy.

Postdocs @lauritsskov.bsky.social and @ekerdoncuff.bsky.social traced Indian's ancestry to three main sources. Read the findings in this story by grad student Jules Perez: bit.ly/3IK46vh

Unmasking the Denisovans The Harbin cranium, linked to Denisovans via mitochondrial DNA, broadens their known range and provides the first insights into Denisovan morphology. …

Vanessa Villalba-Mouco and I wrote a little preview piece for Cell on the new mtDNA and proteomics results from the Harbin skull. It is free for 50 days at this link: www.sciencedirect.com/science/arti...

High resolution analysis of population structure using rare variants Various statistical methods have been developed to identify population structure from genetic data, including F-statistics, which measure the average correlation in allele frequency differences betwee...

"Surprisingly, the resolution of rare variants is even higher than using all variants..." Excited to use this method on Indian population data! @stschiff.bsky.social
www.biorxiv.org/content/10.1...

Whole genome sequencing and assembly of the house sparrow, Passer domesticus Whole genome sequencing and assembly of the house sparrow, Passer domesticus

Our latest articles on Whole genome sequencing and assembly of the house sparrow, Passer domesticus

#passer

gigabytejournal.com/articles/161

Yes, I think a lot depends on the "weighting" given to parts/patterns of the data. What could be done with an ARG may not be possible with PCA. I have noticed a change in the clustering pattern for Indian populations (with differing demographic histories) before and after LD pruning.

Thank you for sharing this paper. @sashagusevposts.bsky.social then the LD regions should greatly influence the number of variant differences. Two African groups with different demographic history may exhibit different set of LD regions resulting in dissimilarity compared to an European group.?

How important is it to account for LD in a PCA given that some populations are bottlenecked and some are not? Uniform LD pruning would erase the very characteristic of a population (similarity/dissimilarity) which is the basis of PCA. Isn't it?

Two useful new reviews on ancestry inference in population genetics:

onlinelibrary.wiley.com/doi/10.1111/...
genomebiology.biomedcentral.com/articles/10....

A common misconception is that genetic drift/bottlenecks erase ancestral components. Yet the persistence of archaic ancestry in India's founder populations proves otherwise. Modern pops like Onge, Paniya, Koraga, Papuan preserve true relics of the human past, sometimes even better than aDNA.

🌾 Agriculture didn’t always spread with mobility of people.
New ancient DNA research shows that in western Anatolia, while communities stayed put, farming and village life spread through the movement of ideas and practices.

50,000 years of evolutionary history of India: Impact on health and disease variation A genomic study of 2,762 individuals from India offers important insights into the genomic diversity and evolutionary history of the subcontinent and highlights the extensive genetic variation, gene f...

Our paper out today: 50,000 years of evolutionary history of India: Impact on health and disease variation: Cell www.cell.com/cell/fulltex...

Artist's reconstruction of the Harbin skull Denisovan. Image by Chuang Zhao

Dragon Man was a Denisovan! DNA and proteins both confirm it, giving this mysterious human lineage a face at long last. Here’s my story. [Gift link] nyti.ms/44nQq1i

On Borders And Belonging - The Genetic Challenge To Nationalism Nationalism thrives on the idea that a nation-state consists of a homogenous people. Yet, genetic ancestry tests contradict the notion of pure, isolated national identities.

Uttryck just published my piece on how genetic ancestry tests have unexpectedly disrupted the notion of nationalism.

Pick up a hardcopy in thier office at Uppsala University!

www.uttryckmagazine.com/2025/04/28/g...

🧵1/n ✨🔮✨ Meet (y)our instructors of this year's #HAAMsummerschool 👇 #aDNA #course #humanpopgen

All biobanks must consider fine scale genetic clusters for a reasonably good understanding of the genetic variation and it's implications. Continental, linguistic, geographical and racial clusters are less effective in real life scenarios.

🔬 Uploading or finding ancient DNA data a headache? Help fix it!
Join our Standards in Human ancient DNA metadata workshop 🧬
🗓️ June 19, 2025
🕐 13:00–16:00 CET
💻 Online | 💰 Free
💬 Feedback = co-authorship possible!
👉 Register: shorturl.at/D3j6i

I Founded Girls Who Code. Now I’m Worried About Boys Boys and men are less likely to turn to their communities for social connection and support.

Just like we need women in STEM and "Girls Who Code", we need “Men Who Nurse” and “Guys Who Teach,” pipeline programs that can offer boys pathways forward in female-typed fields. @reshmasaujani.bsky.social
time.com/7286184/worr...

‼️ PhD opportunity: join a vibrant community working on language evolution @nccrlanguage.bsky.social @isle-uzh.bsky.social please spread widely www.isle.uzh.ch/en/jobs/phd-...

🚨 Don’t miss the 1st HAAM-radio symposium: "Ethics in Human DNA Research"
📅 May 29 (next week!)
🕒 LA (7am) l Berlin (4pm) | Singapore (10pm)
🎙️ With @paleogenomics.bsky.social @jenniferraff.bsky.social @marisolespitia.bsky.social & Tomás Gozález Zarzar
📝 Register by May 28
🔗 shorturl.at/1VScZ

We are happy to proudly report that the #book on #IndoEuropean #prehistoric #linguistic #research, by our #HumanPast Junior #Fellow 2024-25, Axel Palmér is published now! Congratulations, Axel! brill.com/display/titl... @cschlebu.bsky.social #archaeology #genetics #indoslavic #indoiranian #bronzeage

Happy to share a PhD opportunity in my new lab at the University of Zurich! Application deadline: June 30. Do not hesitate to contact me for any questions!

UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups - European Journal of Human Genetics European Journal of Human Genetics - UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups

We proudly present UYSD:
a new open-access repository with global Y-SNP haplogroup frequencies.
A valuable resource for forensic genetics, genetic genealogy, population studies, and more.
👉 www.nature.com/articles/s41...

Check out our ancient DNA paper on the maritime Punic civilization! 🦴🧬🌊

We find that their Levantine Phoenician cultural ancestors contributed surprisingly little ancestry to Punic sites in the central and western Mediterranean! (1/4)

doi.org/10.1038/s415...

#aDNA #PopGen #Punic #Phoenician

Sexual division of labour shapes hunter-gatherer spatial ranges Mobility lies at the adaptive core of the hunter-gatherer foraging niche, and has shaped the cultural and genetic evolution of our species. Yet, the specific drivers and consequences of mobility are s...

🚨New preprint!🚨"Sexual division of labour shapes hunter-gatherer spatial ranges". Following on the sexual division of labour theme, finally out our analyses on the lifetime spatial ranges of over 700 Mbendjele BaYaka 🤩

www.biorxiv.org/content/10.1...

Ancient DNA from the Green Sahara reveals ancestral North African lineage - Nature Pastoralism spread through cultural diffusion into the Green Sahara, where an isolated, distinct North African ancestry persisted.

I'm beyond excited to share our new paper in Nature! We sequenced the first ancient human autosomal genomes from the Central Sahara, two ~7,000-year-old individuals from Takarkori in Libya, revealing a long-isolated North African lineage: www.nature.com/articles/s41...
Here's a short thread: (1/n)

🎓 PhD Position Available in the Population and Evolutionary Genetics group at Trinity College Dublin ☘️ . More details👇