One to share with my screenagers

How Cuts to NIH Research Funding Would Hurt States Proposed changes to the National Institutes of Health’s $48 billion budget would risk jobs, threaten state economies, and hamper progress toward prevention and treatment of diseases such as cancer.

🧪This is a good article explaining why the NIH is such an important institution that benefits all Americans and others globally. For example, NIH funding contributed to 99% of drugs approved for treatment. Drug approval comes after clinical trials.

www.americanprogress.org/article/how-...

“ scientist is largely taught by apprenticeship, with each generation teaching the next.

We risk losing the next generation, our “seed corn”, if they are driven from science by uncertain funding and by political rhetoric that disparages science. “

Sustain regular predictable funding cycles

“Vannevar Bush .. understood that most companies are unwilling to invest in unfettered, curiosity-driven, fundamental research because the fruits of such research and when they will emerge are usually unpredictable.

Our investment in fundamental research has paid for itself many times over.”

“Pursuing new, and sometimes heretical, ideas, and turning them into reality, also requires scientists and investors who can tolerate risk.

In some countries, the worst thing you can do is to fail conspicuously while trying something new rather than to have quietly played it safe. ”

“The fact that so many of the world's best scientists and engineers live in the United States was not, however, preordained. How did we get there?

… doing great science requires the ability to challenge conventional wisdom. It is hard to innovate in cultures that emphasize conformism. “

Incredible insight by Nobel Laureate Bill Kaelin. How to build an innovation economy

Embrace
- freedom of thought,
- break down hierarchy
- challenge the status quo,
- be brave, risk failure
- prime basic research
- encourage diversity.

www.amjmed.com/article/S000...

Our event in Research Week 2025 with keynote speaker Donald McDonnell from Duke University is fast approaching

Registration is available on the link below

#ResearchWeekUL #RW25 #LDCRC #UL #cancerresearch

Meet the winners of the YERUN Open Science Awards 2023!  - Yerun We are delighted to share a recap of the YERUN Open Science Awards Ceremony which was just concluded! The event was a resounding success, bringing together YERUN members, esteemed guests, and stakehol...

Congratulations to Maria Doyle & the Bioconductor Community Advisory Board for winning a YERUN Open Science award. yerun.eu/2024/02/meet...

Slide about presentation: CURIOSS Deep Dive with Dr. Maria Doyle, Community Manager, The Bioconductor Project

We loved this #DeepDive with Maria Doyle, Community Manager of @bioconductor.bsky.social .

She talked about the Bioconductor Project; its impact; and managing a global #opensource community.

📺 www.youtube.com/watch?v=i9_L...

#academicOSPOs #academicOSS #openscience #openresearch #bioinformatics

Adapting systems biology to address the complexity of human disease in the single-cell era | Nature Reviews Genetics Systems biology aims to achieve holistic insights into the molecular workings of cellular systems through iterative loops of measurement, analysis and perturbation. This framework has had remarkable success in unicellular model organisms, and recent experimental and computational advances — from single-cell and spatial profiling to CRISPR genome editing and machine learning — have raised the exciting possibility of leveraging such strategies to prevent, diagnose and treat human diseases. However, adapting systems-inspired approaches to dissect human disease complexity is challenging, given that discrepancies between the biological features of human tissues and the experimental models typically used to probe function (which we term ‘translational distance’) can confound insight. Here we review how samples, measurements and analyses can be contextualized within overall multiscale human disease processes to mitigate data and representation gaps. We then examine ways to

Unlocking human disease complexity: Systems biology evolves in single-cell era with CRISPR, AI, and spatial profiling. PMID:40065155, Nat Rev Genet 2025, @NatureRevGenet https://doi.org/10.1038/s41576-025-00821-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Join CoFest 2025!
CoFest is a community-driven sprint where developers, scientists, educators, and more collaborate on exciting Galaxy & Bioconductor projects. Everyone can contribute, not just programmers!
Learn more and register: gbcc2025.bioconductor.org/cofest/overv...

EuroBioC2025 hex sticker design featuring the Sagrada Família in the centre, vibrant mosaic patterns inspired by Park Güell at the bottom, and other Barcelona landmarks like the crane and towers. The Bioconductor logo replaces the "i" in "BioC", and "bioconductor.org" is written across the top left. The overall shape is a yellow-bordered hexagon.

🎉 Announcing the EuroBioC2025 Sticker Winner!

🏆 Chaima Hkimi’s design features the Sagrada Família, Park Güell colours, and a nod to Bioconductor in the text. Pick up the sticker at #EuroBioC2025!

#Bioconductor #Bioinformatics #RStats #StickerContest

What's new in R 4.5.0? Here we summarise some of the more interesting changes that have been introduced in R 4.5.0.

New version of R is out!

Our Data Scientist, Russ Hyde, has put together a quick review of the key features and changes in R 4.5 — from new language features to graphics updates and more.

📝 Read the full blog post here: www.jumpingrivers.com/blog/whats-n...

#rstats #Rprogramming #opensource

Bit of a slow start to bluesky for me. Looking forward to good discussions. LinkedIn doesn’t do publication
tweetutorials well. What are they called on bluesky?

A great first session with @dchenshall.bsky.social @brendangilmore.bsky.social Laoise McNamara and @aedinculhane.bsky.social … fundamental research usually and ultimately leads to important applications … uncertain, unpredictable, often delayed … but valuable. Curiosity reveals what’s important!