Adam Butterworth aidanbutty

Variant selection to maximize variance explained in cis-Mendelian randomization - PubMed Optimal selection of instrumental variables (IVs) from a single gene region in cis-Mendelian randomization is challenging as variants are highly correlated due to linkage disequilibrium (LD). Using only the lead variant is convenient but may not achieve full statistical power if multiple signals exi …

New paper "Variant selection to maximize variance explained in cis-Mendelian randomization" led by @AngZhou3 and published at @HGGAdvances: pubmed.ncbi.nlm.nih.gov/41548043/, with contribution from @vkarhune.bsky.social, Haodong, Janne, Ash, and Eric. Brief thread:

19.01.2026 12:24 — 👍 6 🔁 5 💬 1 📌 0

ICYMI in the mad rush before the winter holidays, we published a paper looking at integrated risk prediction of cardiovascular disease and modelling both targeted and population-wide intervention in the UK. I was honestly surprised at the potential benefits 👇

12.01.2026 09:49 — 👍 8 🔁 4 💬 1 📌 0

Research Associate (Fixed Term) Postdoctoral Research Associate in vascular cell plasticity and translation (single-cell and omics) (Fixed Term) We invite applicants for a postdoc position (Research Associate) for a project in Dr

Happy New Year!

We are looking for a postdoc with computational expertise to join our group. Deadline for application is 13th January.

www.cam.ac.uk/jobs/researc...

#newjob #postdoc #vascularbiology #atherosclerosis #cellplasticitycontrol #functionalgenomics #cellheterogeneity

05.01.2026 10:14 — 👍 8 🔁 10 💬 1 📌 0

Assistant/Associate Professor in Respiratory Medicine (Honorary Consultant) (Fixed Term) An exciting opportunity has arisen for a new University of Cambridge-Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Respiratory Medicine. We are seeking applications

Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.

www.cam.ac.uk/jobs/assista...

16.12.2025 22:53 — 👍 5 🔁 6 💬 0 📌 0

Assistant/Associate Professor in Cardiology (Honorary Consultant) (Fixed Term) An exciting opportunity has arisen for a new University of Cambridge - Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Cardiology. We are seeking expressions of interest

🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social.
Get in touch if you’d like to discuss the role. We’d love to hear from you!

www.cam.ac.uk/jobs/assista...

16.12.2025 22:55 — 👍 3 🔁 4 💬 0 📌 0

Just published @ Eur Heart J: Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction academic.oup.com/eurheartj/ad...

tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.

15.12.2025 10:00 — 👍 17 🔁 5 💬 1 📌 1

Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction AbstractBackground and Aims. Clinical biomarkers, nuclear magnetic resonance (NMR) metabolomics biomarker scores, and polygenic risk scores (PRS) have show

New paper alert!

@sritchie73.bsky.social @mikeinouye.bsky.social & team found integrating genetic & metabolic blood tests with existing clinical data could enhance how doctors identify people at high risk of heart disease, leading to earlier prevention strategies

Read more tinyurl.com/bp5tjck2

15.12.2025 15:19 — 👍 4 🔁 3 💬 0 📌 0

Ha, all those challenges only came from mistakes I've made previously - and hopefully learnt from!

26.05.2025 14:29 — 👍 2 🔁 0 💬 0 📌 0

I'll be expecting a tattoo of this next time I see you!

26.05.2025 14:27 — 👍 2 🔁 0 💬 0 📌 0

Posts by Adam Butterworth (@aidanbutty.bsky.social)