Fillip Port

piRNAs are essential for transposon silencing in the animal germline.
But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response?

Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

From left to right, Dr. Albert Mulenga, William Tae Heung Kim, Dr. Thu Thuy Nguyen, Dr. Alex Kiarie Gaithuma, Dr Hassan Hakimi and Emily Bencosme Cuevas. Kim is a Texas A&M researcher who was detained in San Francisco last Monday despite being a permanent resident of the United States and a green card holder. COURTESY OF TEXAS A&M UNIVERSITY

I NEED to tell you the story of Tae Heung “William” Kim.

He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.

He's a *legal permanent resident* of the United States.

And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

Motherfucking wind farms…

YouTube video by Gaioum Mr. W

My favourite ad:

www.youtube.com/watch?v=2mTL...

Elgol/Skye?

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis - Nature Communications Single-cell multi-omics in Drosophila testis reveals enhancer-driven gene regulatory networks and shows how Wnt signaling and key transcription factors orchestrate stem cell maintenance and lineage pr...

I am so happy to announce that our Drosophila testis multiome paper is now published in Nature Communications !!! I am very happy and proud of all who contributed, in particular Patrick and Pallavi who did an amazing job! www.nature.com/articles/s41...

pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...

Thanks. Was not aware of this tool. Still feel it should be a basic functionality of the app, but this is certainly better than nothing.

a man with a mustache is sitting on a swing in a park ALT: a man with a mustache is sitting on a swing in a park

Still waiting for bookmarks on this platform...

First preprint from the Bageritz Lab!
Key contributions from Laura Schütze and @mariamusillo.bsky.social, and many helping hands across the lab. Thanks to @cosheidelberg.bsky.social & @sfb1324.bsky.social for their support.
www.biorxiv.org/content/10.1...
#MuscleDevelopment #WntSignaling #SFB1324

This Osprey is so majestic…. 🥰
And in the bird world this is considered a sick move….

Sometimes I can't tell whether LLM used too much training data from LinkedIn, or too many people use LLM to write LinkedIn posts.

Congrats. No one can turn a fish into a fly like you guys.

Hitting ‘undruggable’ disease targets – Institute for Protein Design Custom proteins made with AI bind disordered proteins and peptides with atomic precision.

The Baker lab @uwproteindesign.bsky.social did it again 😱

Protein design of IDPs binders

www.ipd.uw.edu/2025/07/hitt...

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) - Nature Communications Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and gen...

Pooled #CRISPR screens are a staple of functional genomics in mammalian cells. Yet somehow in the best genetic model™ no equivalent system was available. Until now! The @perrimonlab.bsky.social lab now presents efficient pooled CRISPR screening in #Drosophila cells.

www.nature.com/articles/s41...

Hey @nature.com What's up with your share buttons? Can we please also get 🦋 and 🦣 options to not exclusively promote the network of the guy who has done more than most to harm US science?

Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

Drosophila for the win! When you can afford more than 3 subjects per experiment, your results get more reliable...

www.nature.com/articles/d41...

Giant study finds a research field that’s mostly reproducible Researchers assessed more than 1,000 results from fruit-fly immunity research published between 1959 and 2011. The majority of findings look verifiable.

A huge project has analysed more than 1,000 claims about the immunity of Drosophila fruit flies in scientific papers published over some 50 years

go.nature.com/4lxhwJB

Male birds need a specific microRNA to survive - without it, they get a lethal gene 'overdose' from having two Z chromosomes. Yet another evolutionary solution to sex chromosome imbalance. Cool science from @kaessmannlab.bsky.social 🐔🧪

Majority of fruit fly immunity studies can be replicated, huge analysis finds Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up

Comment on our @Reproducibility project in @Drosophila immunity. It is a normal that findings—however exciting and important at the time—may later prove to be more complex than initially believed. Re-evaluations is essential to the self-correcting nature of science. www.science.org/content/arti...

Schluss mit "Up or Out"

Schluss mit up-or-out, Department Strukturen, mehr dauerhafte Optionen im Mittelbau, mehr horizontale Flexibilität, etc. Viele gute Punkte im Papier des Wissenschaftsrat zu Arbeitsbedingungen in dt. Wissenschaft. Leider bisher kein Thema das zu Optimismus einlädt.

www.jmwiarda.de/blog/2025/07...

No, AlphaFold has not completely solved protein folding Biology is hard. Yes, even for AI.

AlphaFold is great, but contrary to public opinion it has not completely solved the protein folding problem. Much work remains to be done.
clauswilke.substack.com/p/no-alphafo...

Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Secreted proteins regulate many aspects of animal biology and are attractive targets for biomarkers and therapeutics. However, comprehensively identifying the "secretome", along with their tissues of ...

I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️.
Thread below🧵
1/8
www.biorxiv.org/content/10.1...

Kicking off the lab BlueSky with this picture of a happy hairy growing #axon!
Looking forward to connecting with science chats and to growing research ideas 🧠🔬✨

Graffiti at the end of an underpass in Heidelberg saying 'LAB!'.

Some PIs will stop at nothing to motivate their lab members. 🧪

SARCOMERES divide! Mechanism how muscles grow while contracting - daughter sarcomeres appear everywhere. Seen live, registered on our cover. Pioneered by @clementrodier.bsky.social @friedrich-group.bsky.social Ian Estabrook @ibdm.bsky.social $ by @hfspo.bsky.social www.science.org/doi/10.1126/...

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

gold crispr-cas9 enamel pins

drosophila embroidered patches and enamel pins

IgM antibody enamel pins in purple and cyan

All proceeds from my #sciart Etsy shop will now be donated to
@flybase.bsky.social . Due to fed cuts, this beloved resource that I use daily has lost it's funding, and I'm helping in my small way. Now's a good time stock up on #STEM & #drosophila gifts & swag!
www.etsy.com/shop/Picosti...

If the Royal Society had decided to expel Elon Musk simply for violating their Code of Conduct, they wouldn't now face the embarrassment of having a Fellow who built MechanoHitler. Hey ho.