Silas Maniatis

Good chance I would not be a scientist if CPB had not funded @pbs.org programs like Nova and Nature. 3 2 1 Contact, Electric Company, and McNeal Lehrer News Hour were pivotal in my intellectual development too. What a crime against this country this nihilistic nonsense is. cpb.org/pressroom/Co...

Congrats Megan, Harm, @davidaknowles.bsky.social @nevillesanjana.bsky.social and co! Really nice paper and a great toolset for the community to interrogate the biological relevance of isoform usage!

Popcorn

Former @1199seiu.org member here… Great to see that unlike DNC leadership, my former local gets what’s up. Even if you made the mistake of thinking corporate Dems were the way to go in the primary, you get behind the guy energizing the base.

Several NYPD unions endorse Mayor Adams despite corruption allegations The Police Benevolent Association, the city’s largest police union representing rank-and-file NYPD officers, has not announced whom it will endorse.

I am extremely pro-union… however, please remember that only 48% of NYPD personnel actually live in the 5 boroughs… soooo, they can take their endorsements back to LI and NJ and vote for the most corrupt NY mayor in modern history to run Levittown or wherever.

gothamist.com/news/several...

Loved the preprint, congrats on the paper!

NYC Immigration Arrests Just Shot Through the Roof, New Data Shows Newly obtained federal records offer the clearest picture yet of how aggressively the Trump administration has pursued its mass deportation agenda — with a sixfold increase in arrests in early June.

"ICE arrests jumped 46% this May, to 409 up from 281 last year. In the first 10 days of June, ICE agents in NYC made 495 arrests— more than 2x the 247 arrests it made in all of June last year.”

👇See how ICE's access to our immigration courts is increasing this trend.
www.thecity.nyc/2025/07/14/i...

Brain–computer interface restores naturalistic speech to a man with ALS Nature Reviews Neurology, Published online: 08 July 2025; doi:10.1038/s41582-025-01122-6A voice-synthesis neuroprosthesis based on a brain–computer interface has restored instantaneous, natural-sounding speech to a man with amyotrophic lateral sclerosis.

ICYMI: New online! Brain–computer interface restores naturalistic speech to a man with ALS

Engineering Faster Cures at the FDA New plans to upend America's health bureaucracy

I'm growing confident that the latest policy to limit use of animals in HHS research is motivated to move $$$ to Palantir.

Palantir co-founder says this: blog.joelonsdale.com/p/engineerin...

NIH says this: grants.nih.gov/news-events/...

Pure grift by tech-bros who don't know biology...

Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.

In an unprecedented move, the NIH will soon disinvite dozens of scientists who were about to take positions on advisory councils that make final decisions on grant applications for the US agency, Nature has learnt.

go.nature.com/3TEw7GN

What app is that?

8:00 summer BK vibe is undefeated

World’s premier cancer institute faces crippling cuts and chaos | CNN The Trump administration’s broadsides against scientific research have caused unprecedented upheaval at the National Cancer Institute, the storied federal government research hub that has spearheaded ...

www.cnn.com/2025/07/08/h...

Kennedy Abruptly Cancels USPSTF Meeting Move raises concern that the task force may face a similar fate as CDC's federal vaccine advisors

this seems like a pretty big deal

Solid phase transitions as a solution to the genome folding paradox - Nature In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rathe...

Just noticed that Stavros has put out another 'solid' paper last month. 🔥 Impressive given what he has to deal with these days.

www.nature.com/articles/s41...

Case 8:25-cv-00951-PX Document 211 Filed 07/02/25 Page 2 of 5 3. The proposed Amended Complaint details the Government's defiance of court orders after this Court granted preliminary injunctive relief. The Amended Complaint includes allegations that the Government made decisions to defy judicial mandates. These allegations are new to the Complaint, but have been cited in various filings in this Court as the case has developed. They are directly relevant to Plaintiffs' constitutional claims and outstanding requests for declaratory and prospective injunctive relief. 4. Plaintiffs also seek to incorporate evidence that emerged in a June 2025 whistleblower disclosure from former DOJ official Erez Reuveni, who was previously counsel for the Government in this case. The new allegations include government officials internally acknowledging that Abrego Garcia's removal was an "administrative error" while simultaneously working to prevent his return and to make post-hoc justifications. These revelations provide evidence of deliberate misconduct that was unavailable when the original Complaint was filed and directly support Plaintiffs' claims. 5. The proposed Amended Complaint also Includes Abrego Garcia's first-hand account of torture and mistreatment at CECOT, as well as developments regarding his return to the United States and the Government's stated plan to remove him again. These allegations identify the severe harm actually suffered and the threat of repeated unlawful removal that supports Plaintiffs' request for prospective injunctive relief. The inclusion of these facts, which could not have been pleaded at the time of the original filing, is essential to present a complete picture of the violations and ensure adequate relief. 6. Plaintiffs also propose to clarify that the relief sought includes restoring the status quo ante, which requires (among other things) the Government to return Abrego Garcia to 2

NEW: Kilmar Abrego Garcia’s lawyers seek permission to file an amended complaint in his civil case in Maryland.

Among other things, the amended complaint “includes Abrego Garcia's first-hand account of torture and mistreatment at CECOT…”

I imagined the Chatsubo in 1984. 41 years later I opened its door. Neuromancer is in production.

Excerpt from the proposed 2026 NOAA Budget, showing the total funding for climate research reduced from $220 million per year to $0.

The proposed NOAA budget for 2026 contains the literal line:

Total, Climate Research: $0

www.commerce.gov/sites/defaul...

Tahoe-100M

Single-cell transcriptomic perturbation atlas🤠

~100 M cells
~50 Cancer cell lines/spheroids (any normal cell for toxicity?)
~1100 small-molecule agents
52k cell-drug interactions
Mosaic platform

#OpenScience #VirtualCell
bioRxiv 2025
www.biorxiv.org/content/10.1...

ICE Is Using a New Facial Recognition App to Identify People, Leaked Emails Show The new tool, called Mobile Fortify, uses the CBP system which ordinarily takes photos of people when they enter or exit the U.S., according to internal ICE emails viewed by 404 Media. Now ICE is usin...

New from 404 Media: ICE is using a new facial recognition app to identify people, leaked emails show. Point camera at person, reveal their identity. It uses the CBP system that records peoples' faces as they enter or exit the U.S. Now, turned inwards to be used by ICE www.404media.co/ice-is-using...

The one on the left is the Brooklyn navy yard. It’s weird that even one person lives there. I think the one on the right is the big USPS facility by Chelsea piers.

If this has happened to you today, get in touch with us at tips@hellgatenyc.com.

Read more on our live blog: hellgatenyc.com/hell-gate-ny...

Video captured the moment a road buckled and sent a car flying as a heatwave impacted Missouri on Sunday.

Oligarchy, baby.

🔬In this month's Editorial, we announce a cross-journal pilot at @natureportfolio.nature.com journals aiming to implement standardized light and fluorescence #microscopy reporting to improve methodological description and aid in #reproducibility efforts.
👉https://rdcu.be/esnOK

bit.ly/3TAzZIK

Without making any endorsements, it does seem like in a city of 8.5 million residents, it’s not too much to ask for the mayor to actually live in New York City.

BREAKING: Judge denies NSF's 15% indirect rate plan. Like the DOE and NIH attempts, it too has now been rejected by courts. storage.courtlistener.com/recap/gov.us...

calling all fly folks, keep an eye out for new system coming soon, through which you can help support FlyBase in this time of dire need.

Advisory Committee on Immunization Practices at a Crossroads In this Viewpoint, former members of the Advisory Committee on Immunization Practices (ACIP) caution that the sudden change in the ACIP may reverse the achievements of US immunization policy, includin...

jamanetwork.com/journals/jam...