Silas Maniatis

It’s been amazing to watch the growth of the biomedical industry in NYC over the past decade. It’s also terrible watching it be destroyed by federal actions. To remain competitive with respect to national and global centers of biomedical research and industry, NY state must step in and invest!

Still my favorite 3D reconstruction of a pancreatic tissue.

Using the CODA workflow, we mapped a billion individual cells in 3D.

Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
Yellow: fat

More here: www.nature.com/articles/s41...

Cloning is cool! I prefer the blue edition with the EM image of a phage and plastic binding though..

a man with a beard is looking at the camera with the words priorities written on the bottom ALT: a man with a beard is looking at the camera with the words priorities written on the bottom

Another new policy from the geniuses in NIH leadership.

Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section.

This is an increase from the ~50% level that has been in place for many years.

I don't know the rationale for this

1/13

Millionaire Tax That Inspired Mamdani Fuels $5.7 Billion Haul in Massachusetts A millionaire levy in Massachusetts that New York City mayoral frontrunner Zohran Mamdani holds up as a model for taxing the rich has generated $3 billion more in revenue than expected without forcing...

NEW: The first two years of Massachusetts' millionaire tax has raised $3 billion more than expected.

And rather than driving the rich away, IPS researchers found that the number of millionaires has *increased.*

Tax the rich. Greg Ryan in @bloomberg.com:

If they send the money out $2k at a time to 100s of millions of people, it will be that much harder for the Supreme Court to rule the tariffs unconstitutional because it would be impossible to claw the money back. So heads trump is emperor, tails there’s no consequences when he does illegal stuff.

Saturday 11/9/25

Q: Will you assure House Democrats they'll get a vote on ACA subsidies by a date certain?

MIKE JOHNSON: Ah -- no. I'm not promising anyone anything.

YouTube video by Mobb Deep Mobb Deep - Shook Ones, Pt II [Instrumental]

youtu.be/v9MILl7AMLo?...

bsky.app/profile/adam...

One of my favorite things about the Mamdani sign style meme is how few people posting them have any interaction with the fact they are clearly a callback to NYCHA signage.

NYPD Commissioner Jessica Tisch got Trump admin heads up before ICE raid on Canal Street The revelation that Tisch had advance knowledge of the Trump administration’s Canal St. raids could raise a number of complicated questions for Zohran Mamdani, the mayoral-elect who has said …

New: NYPD Commissioner Jessica Tisch got advance notice from the Trump admin that ICE agents were about to conduct their aggressive Canal St. immigration raid — a revelation that could raise complex questions for Mamdani, who wants to as mayor keep her as PC. www.nydailynews.com/2025/11/06/n...

BREAKING: A federal jury in Brooklyn awarded our clients — 674 immigrants unlawfully jailed by the Suffolk County Sheriff’s Office — $112 million. Could not be more proud to work at @latinojustice.bsky.social and to partner with the talent of Winston & Strawn.

I had to double-check that I hadn’t fever-dreamed Cuomo buying a white Ford Bronco a long time ago.

He’s had over 10 years to realize the bad optics of driving this thing around, but instead rolls it out in the closing hours before Election Day.

And parks in a bike lane, as a cherry on top.

The Sun has produced four moderate (M-class) solar flares today. We expect solar activity to continue increasing for the next week or so, as busy regions on the Sun rotate to face Earth!

Just hit 4K miles on the family cargo bike while taking the kids to school this am. This thing has been one of the biggest parental level-ups we’ve discovered. It’s made the commute something the kids look forward to, and has cut my commute (which was not bad to start) in half.

"HOW WILL ZOHRAN PAY FOR FREE BUSES" screamed the Staten Islanders who have a free ferry

NOAA cancels longstanding funding for seismic data collection crucial to tsunami warning systems The Alaska Earthquake Center has long provided NOAA with seismic data for tsunami monitoring and warning purposes. That work will wind down in November, after the federal agency said it can no longer fund the contract.

NOAA’s National Weather Service holds the federal responsibility for tsunami warnings, and has historically been a primary supporter of seismic data collection in Alaska

Welp, I guess that’s confirmation of Murphy’s law

What?!!!!! Never seen a ball caught by the earth/wall before

I’m @manimota .. Dodgers second only to the Sox for me. Ohtani is maybe the greatest player in my lifetime… Rooting for Canada right now

A ghostly skull shape, defined by two darker areas where the eyes would be, and the lower portion of which fades into the grey speckled pattern of the background.

This day ten years ago.

On 30 October 2015 the now-destroyed Arecibo radio telescope images this giant skull looming out of the dark of space.

Just FYI, @thelotradio.com has a community fridge and great music. If you’re in North Brooklyn, please consider donating there, or to any other food bank (North Brooklyn Angels is another good one). 1/8 of us are about to lose vital nutritional support. If you have the means, help your neighbors

Also… for those that don’t know, ‘Defend NYC’ & ‘Fix the city’ are billionaire superpacs. Michael Bloomberg is one of the most important contributors to the legal milieu that gave rise to ‘Kavenaugh stops’ (and to NYGC)

Governor Kathy Hochul is speaking on stage, but the crowd keeps interrupting to chant #TaxTheRich

@zohrankmamdani.bsky.social

I mean, dude has a pied-a-terre here I guess, but snuggles with his leaded gas era Camaro upstate most nights.. anyway…. If there’s an honest debate over progressive local taxation though.. Check out what happened in Boston when they put in a wealth tax. (Hint. The billionaires didn’t move)

💡Just presented our new paper at the @iccv.bsky.social BioImage Computing workshop: cubic: CUDA-accelerated 3D Bioimage Computing. We introduce a simple way to add GPU acceleration to scikit-image–based bioimage processing pipelines by swapping import statements. 🧵
1/6 #iccv2025

www.thecrimson.com/article/2025...