Christiana Fogg

This month’s cover illustration depicts the repopulation of cardiac-resident macrophages with cardioprotective monocyte-derived cells as chemotherapy-guided patchwork mending of the cardiac macrophage pool.

The January 2026 issue of #ScienceImmunology is out!

This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu

Qianjiadong Reservoir in southern Hunan, China, produces a double harvest: solar energy and yellow carp. The solar farm produces up to 80 megawatts of power while the fish forage beneath the panels. With a massive scale-up of solar and wind at home and cheap exports of the technology, China is driving a worldwide surge of renewable energy—Science’s 2025 Breakthrough of the Year.

Science has named the seemingly unstoppable growth of renewable energy worldwide as the 2025 Breakthrough of the Year.

Learn more about this year's #BOTY and other big advances in science: https://scim.ag/493Tpgx

#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay!

I hope to see many of you in marvelous Ghent this coming March!

AI immunologists are here: Are they ready for prime time? AI-based tools can help immunologists with a range of tasks but have limitations.

An accompanying Focus by John Tsang (@tsanglab.bsky.social) provides a broader perspective of #AI & #immunology.
www.science.org/doi/10.1126/...

Assessing AI’s cognitive abilities for scientific discovery in the field of systems vaccinology LLMs assessed with “The Creation Game” show promise in aiding systems vaccinology discovery while remaining human dependent.

In #Science #Immunology Bali Pulendran's lab at @stanfordmedicine.bsky.social tests 5 different #LLM models to see how well they can accelerate #vaccine #research in combination with human creativity.
www.science.org/doi/10.1126/... 🧪🧫🥼💻

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.

This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

In our latest vaccine immunology study we tested whether it is possible to simultaneously prime multiple classes of broadly neutralizing antibodies (bnAbs) against HIV using a combination of germline-targeting (GT) immunogens. www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @lji.org

To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!

bit.ly/SciImm_free

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

Inhibitory immune checkpoints in cancer immunotherapy Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

That time I was subject of scientific study, and not an editor.....🏃‍♀️🧪

An illustration depicting the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes.

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

Abstracts - IUIS 2025 ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!

You can submit your abstracts here: iuis2025.org/abstracts/

I hope to see many of you this August in beautiful Vienna!!!

#Immunology #Science2025 #CallForAbstracts #IUIS

Happy World #DayofImmunology!

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...

This month's Science Immunology cover features a hungry dog waiting patiently for a treat.

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.

Read about this study and more: scim.ag/4j3gx2A

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB
www.science.org/doi/10.1126/...

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Dynamic STING repression orchestrates immune cell development and function Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. Image credit: A. Fisher/Science Immunology

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy AAV delivery of antibodies targeting the SIV envelope glycoprotein contains virus replication in macaques after stopping ART.

This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!

TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R–BCL6 signaling nexus TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.

This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.

Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs

This is ... a public ... service ... announcement!