Christiana Fogg

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

Abstracts - IUIS 2025 ABSTRACTS ALL ABOUT SUBMISSION IMPORTANT INFORMATION LATE ABSTRACT SUBMISSION IS NOW OPEN guidelines LATE ABSTRACT SUBMISSION GUIDELINES Important Dates 20 November 2024 – Abstract Submission Opens 25...

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)!

You can submit your abstracts here: iuis2025.org/abstracts/

I hope to see many of you this August in beautiful Vienna!!!

#Immunology #Science2025 #CallForAbstracts #IUIS

Happy World #DayofImmunology!

Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses Expanded CD4+ T cell clones preferentially adopt a single fate in malaria, and TR1 cells dominate and display long-term memory.

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸
www.science.org/doi/10.1126/...

This month's Science Immunology cover features a hungry dog waiting patiently for a treat.

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels.

Read about this study and more: scim.ag/4j3gx2A

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB
www.science.org/doi/10.1126/...

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.

New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

Dynamic STING repression orchestrates immune cell development and function Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. Image credit: A. Fisher/Science Immunology

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

Check out the paper below with its related Perspective in @science.org
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy AAV delivery of antibodies targeting the SIV envelope glycoprotein contains virus replication in macaques after stopping ART.

This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!

TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R–BCL6 signaling nexus TRAF3 integrates early cell-intrinsic and cell-extrinsic signals to initiate TFH cell differentiation.

This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/...
Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma Single-cell and spatial multiomics analyses identify breakout lesions as a hotspot for tumor-immune interactions and diversification.

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer.

Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs

This is ... a public ... service ... announcement!

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

Human naïve B cells recognize prepandemic influenza virus hemagglutinins Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

check your chat! The bluesky world's your oyster!

@karenvincent.bsky.social welcome!

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

Reversing the Hands of Time. Inflammaging is the age-associated increase in systemic inflammation, which can have negative effects on blood cell production and the immune system. Using a mouse model of premature hematopoietic aging, Ramalingam et al. identified thrombospondin-1 (Thbs1) as a driver of age-associated changes to hematopoietic stem cells (HSCs). Deletion of Thbs1 prevented HSC myeloid bias, loss of HSC self-renewal, and systemic signs of inflammaging in aged mice. This month’s cover illustration depicts the process of HSC inflammaging as a pocket watch. Thbs1 gene deletion causes the watch hands to move backwards, which reverses aging-associated HSC defects and turns back the clock on inflammaging. Credit: Rioka Hayama

The January issue of #Science #Immunology is now live! This week: new insights into #NLRP3 #inflammasome activation; key distinctions btw rodent & human #PD1 orthologs uncovered; & targeting thrombospondin-1 (Thbs1) to suppress #HSC #inflammaging!

www.science.org/toc/sciimmun...

Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...

Functional differences between rodent and human PD-1 linked to evolutionary divergence A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.

First issue of #Science #Immunology out for 2025! Check out this paper by Masabuchi et al. defining why rodent and human PD-1 function differently!🐀🚶‍♀️@enfuhui.bsky.social
www.science.org/doi/10.1126/...

My holiday gift to all of you: The editors of @science.org's favorite papers of 2024, all wrapped up nicely in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

Good news on a H5N1 vaccine efficacy in a preclinical model in case it is needed
science.org/doi/10.1126/...