Paul Orwin

@markowenmartin.bsky.social I'm sitting here at ASM biofilms, just heard Jo Handelsman talk (she gave you a little shoutout), and now hearing your former student Ruth Isenberg talk about E. faecalis! she is now working in the building i did my phd in which is a real "small world thing"!

Home wins against bottom half. So far we are 2/2 on that score (right? Am I forgetting something?)

But dropping Farke now is really, really dumb. And there is a brutal run of fixtures between now and mid-January. I wouldn't be surprised to see them on 17-18 pts after 20 games. But if Farke gets the sack after losing to Citeh and Liverpool that seems quite silly to me...

its funny b/c i listen to the square ball, and they say "10 wins thats the goal" but if we lose two games its "Farke out, we need a change"
I get it, its really frustrating to watch them play poorly (and they did) but its gonna happen (also, I thought Nmecha's finish was great, Bijol needs to sit)

Maybe sneak one win against top half overall (probably at home). 3 or 4 draws against top half at home, 3-4 draws against bottom half at theirs. That's the target and that probably gets us 17th place. A couple wins on top of that and your in 14th. Its a tough division...

they are having a poor run of form. but they aren't outside of expectations (if anything a bit above them). I'm not really looking at the table, i'm looking at expected wins from each match. My baseline for survival - win 7/9 against bottom half at home, win 3/9 against bottom half away.

They are on track for about 10 wins right now. 10 wins 10 draws 18 losses is survival. Very doable with this squad and this manager. Most of the summer signings have been fine, all have room to improve. Shore up the back and this team cruises to 40 pts #lufc

#LUFC fans understandably are upset but everyone needs to remember what the survival strategy is; win at home against bottom half opposition, get a couple of smash and grab wins away, get some draws against the top half. That’s the path to 40 points and survival. 1/2

I resemble that remark...

Why Does So Much New Technology Feel Inspired by Dystopian Sci-Fi Movies?

The NYT, with its finger on the pulse of American culture, has discovered the "Don't create the Torment Nexus" meme
www.nytimes.com/2025/11/05/m...

so you're saying bet it all on a win against Forest?

this is totally insane.

I guess Colston Loveland was a good draft pick...

omg omg omg etc

OMG Chicago Bears WTAF are you doing?

I mostly don’t care about either one of these teams (OAKLAND A’s fan till I die) but I do feel bad for Geddy Lee.

i don't think i'd be placing any bets on that happening here...

since i'm saturday sports posting, this @scottishrugby.bsky.social vs @usarugby.bsky.social match is men against boys. I am a big supporter of Scotland Rugby, but its making me a bit sad. The "Tier 1 vs Tier 2" rugby nations feels pretty accurate today.

That said, I don't understand the "Farke out" crowd. The players were outclassed at every position. At some level you have to hold the actual players responsible for their performance. I don't think it was a bad plan, just poor play from #LUFC and a gulf in class at pretty much every position.

worst performance of the year (and I'm including the Arsenal game) for #LUFC. They were passive and slow to the ball, looked like a Carabao Cup match between a PL side and a League One side until the last 10 minutes when Brighton were coasting. hard to watch

Here’s How the AI Crash Happens The U.S. is becoming an Nvidia-state.

good rule of thumb. when the phrase "sophisticated financial engineering" is used, grab your wallet with both hands...
www.theatlantic.com/technology/2...

31 years ago today, no TV and no beer made Homer Simpson something something. “Treehouse of Horror V” premiered October 30, 1994.

I don’t think I have ever been this happy not to be watching a Gopher game. What. Is. Happening…

Well that was a nice one (a little nervy at the end, as #LUFC always do it). So where does Brenden go to get his apology?

I’m not a Warriors fan, but if you haven’t seen it in awhile it is simply incredible to watch Steph Curry play basketball. Gotta respect it

CBS poll on Prop 50 in California (the redistricting amendment): Yes 62%, no 38% among likely voters.

www.cbsnews.com/news/cbs-new...

I used the RNA kit from Zymo (Direct-zol) because it gave me very good yields at a relatively low cost? I think on the order of 4-5 bucks per sample.
its a trizol kit with all the columns etc. pretty easy to get good yields from all growth phases etc

graph of the relationship between fucking around and finding out

followed closely by this graph...

Brooklyn99 Brooklyn Nine Nine GIF Alt: Brooklyn99 gif woman surprised that her actions have consequences

It feels like our current situation as a society (political, social, and economic) is summed up in this one GIF

Completed genomes from Variovorax provide insight into genome diversification through horizontal gene transfer Approximately 10% of all bacterial genomes sequenced thus far contain a secondary replicon. This property of bacterial populations vastly increases ge…

Still a couple of formatting things that need fixing (this is a "pre-proof") but our genomes paper is now available online! www.sciencedirect.com/science/arti...
Really happy to see it out there, I hope people find it useful/interesting!