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Rick Huganir

@rhuganir.bsky.social

I am a neuroscientist at Johns hopkins University interested in the molecular mechanisms underlying learning and memory in health and disease.

1,821 Followers  |  152 Following  |  46 Posts  |  Joined: 03.09.2024
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Posts by Rick Huganir (@rhuganir.bsky.social)

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δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice At PSD, the N-cadherin-δ-catenin-ABP/GRIP complex functions as an anchor for GluA2. Heterozygous δ-catenin KO and G34S mice show impairments in social behavior and fear learning and memory. Only KO ha...

"δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice"
www.ibroneuroscience.org/article/S030...

07.02.2026 18:15 — 👍 1    🔁 1    💬 0    📌 0
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The winner of OneNeuro's January #FotoFriday #FluorescenceFriday contest is "Electrophysiology of Cultured Neurons" submitted by Madison Yorkowski in the Ali Fatemi Lab at Kennedy Krieger Institute.

View the complete gallery of OneNeuro BRAINART images here: www.oneneurojhu.org/art/

06.02.2026 19:50 — 👍 8    🔁 2    💬 0    📌 0
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New Neuroscience Masters Degree at Johns Hopkins
The M.S. degree in Neuroscience is a full-time in-person program consisting of intensive coursework followed by 12 months of laboratory research. The application deadline is May 15, and more information is available at neuroscience.jhu.edu/graduate/51

06.02.2026 16:46 — 👍 1    🔁 5    💬 0    📌 0
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"Choose your training environment carefully. Lab culture and institutional culture will significantly impact your happiness and success, so choose carefully." - OneNeuro Profile: Seth Blackshaw, PhD @sethblackshaw.bsky.social www.oneneurojhu.org/2026/01/29/o...

29.01.2026 20:40 — 👍 4    🔁 1    💬 0    📌 3
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Johns Hopkins scientists discover that brain cells constantly attempt to produce myelin at a steady pace throughout the brain, offering new insights for treating multiple sclerosis. @jhu.edu
www.oneneurojhu.org/...

27.01.2026 14:15 — 👍 5    🔁 4    💬 0    📌 0
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"We study human vision, focusing on the neural and computational basis of high-level vision using cognitive and computational neuroscience techniques." — Mick Bonner , PhD @mickbonner.bsky.social www.oneneurojhu.org/2026/01/21/o...

21.01.2026 18:04 — 👍 4    🔁 1    💬 0    📌 0
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Study section done. Now can enjoy the PC learning and memory meeting! Looking forward to some stimulating science chats on the ski lift as well this weekend.

09.01.2026 22:29 — 👍 22    🔁 1    💬 0    📌 0

Rescue of excitotoxicity in a mouse model of a rare neurodevelopmental disorder by ASO treatment.

06.01.2026 09:15 — 👍 4    🔁 1    💬 0    📌 0
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Rescuing Neurodevelopmental Deficits in AMPA Receptor Gain-of-Function Mutant AMPA receptors (AMPARs) mediate fast excitatory synaptic transmission and are essential for neuronal development and brain function. We investigated the role of a recurrent variant in the AMPAR GluA1 ...

We just posted our new paper, “Rescuing Neurodevelopmental Deficits in AMPA Receptor Gain-of-Function Mutant”. In this paper, we, in collaboration with Shu-Ling Chiu's lab, generated a mouse model of a rare missense mutation in the AMPA receptor GluA1 subunit.

www.biorxiv.org/content/10.6...

02.01.2026 16:21 — 👍 2    🔁 1    💬 0    📌 1
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The winner of OneNeuro's November #FotoFriday #FluorescenceFriday contest is "Portrait of a Claustrocortical Neuron" submitted by Baldomero B. Ramírez Cantú in the Solange Brown Lab at @hopkinsmedicine.bsky.social

View the complete gallery of OneNeuro BRAINART images here: www.oneneurojhu.org/art/

19.12.2025 22:52 — 👍 14    🔁 4    💬 0    📌 0
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The winner of OneNeuro's October #FotoFriday #FluorescenceFriday contest is "Purkinje cell complex spikes & simple spikes," submitted by Chenhao Bao in the Cullen lab at JHU Biomedical Engineering. @thecullenlab.bsky.social @chenhaobao.bsky.social
Complete gallery: www.oneneurojhu.org/art/

07.11.2025 23:27 — 👍 12    🔁 3    💬 0    📌 0
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Johns Hopkins scientists discover how brain cells form nanotube networks to transport toxic molecules like amyloid-beta between neurons, offering new insights into Alzheimer's disease progression. @hyungbaekwon.bsky.social @hopkinsmedicine.bsky.social @science.org www.oneneurojhu.org/2025/11/06/n...

06.11.2025 15:52 — 👍 3    🔁 1    💬 0    📌 0
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Four @jhu.edu @jhuartssciences.bsky.social faculty members were recently named part of three large-scale, multi-institutional, highly competitive collaborations funded by the @simonsfoundation.org to explore novel areas in established fields.

www.oneneurojhu.org/2025/09/23/f...

23.09.2025 16:42 — 👍 4    🔁 1    💬 0    📌 0
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New test detects brain cancers in cerebrospinal fluid with 80% sensitivity and 100% specificity, enabling clinicians to better detect cancer and better understand the disease status, supporting a more tailored approach to patient care. @hopkinsmedicine.bsky.social www.oneneurojhu.org/2025/10/06/t...

06.10.2025 18:34 — 👍 1    🔁 1    💬 0    📌 0
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The winner of OneNeuro's September #FotoFriday #FluorescenceFriday contest is "The Cochlear Constellation," submitted by Yassine Balhi in Amanda Lauer's lab at @hopkinsmedicine.bsky.social.

View the complete gallery here: www.oneneurojhu.org/art/

10.10.2025 14:14 — 👍 5    🔁 2    💬 0    📌 0
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Novel in utero gene therapy shows promise for spinal muscular atrophy, with potential to help babies reach motor milestones previously thought impossible. @hopkinsmedicine.bsky.social
www.oneneurojhu.org/2025/10/15/n...

15.10.2025 18:25 — 👍 2    🔁 1    💬 0    📌 0
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I am excited to announce that the Johns Hopkins University Solomon H. Snyder Department has become an interdivisional department between the School of Medicine and the Krieger School of Arts and Sciences, unifying neuroscience research and education across the university. hub.jhu.edu/2025/09/15/j...

19.09.2025 14:16 — 👍 26    🔁 3    💬 0    📌 0
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OneNeuro's August #FotoFriday #FluorescenceFriday contest winner is "Cellular Subtype Composition of an Amphetamine-activated Ensemble in mPFC," by Suhaas Adiraju from @martinowk.bsky.social at the @lieberinstitute.bsky.social

View the complete gallery here: www.oneneurojhu.org/art/

05.09.2025 16:49 — 👍 23    🔁 5    💬 0    📌 0
Caroline Kennedy calls cousin RFK Jr a 'predator' | ABC NEWS
YouTube video by ABC News (Australia) Caroline Kennedy calls cousin RFK Jr a 'predator' | ABC NEWS

The statement by Caroline Kennedy about RFK Jr has aged well www.youtube.com/shorts/fm0-a...

28.08.2025 22:12 — 👍 6    🔁 5    💬 0    📌 0

My hero!!!!

22.08.2025 19:29 — 👍 31    🔁 5    💬 2    📌 0
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Johns Hopkins scientists discover how a protein organizes message-carrying "bubbles" in brain synapses—advancing understanding of memory formation and learning. www.oneneurojhu.org/...
@watanabelab.bsky.social

20.08.2025 13:15 — 👍 17    🔁 4    💬 0    📌 0

Susan would love this !

21.08.2025 03:07 — 👍 1    🔁 0    💬 0    📌 0

A giant in the field! Gave some of the best talks I have ever seen.

19.08.2025 01:33 — 👍 4    🔁 0    💬 0    📌 0

A legend. Was and am still inspired by his work. Sad to hear this.

18.08.2025 23:17 — 👍 14    🔁 3    💬 1    📌 1

Go Tricia! Go Hopkins!

11.08.2025 23:55 — 👍 7    🔁 1    💬 0    📌 0
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We are thrilled to announce that OneNeuro Co-Director Patricia Janak, Ph.D., has been elected as the 2026-2027 President of the Society for Neuroscience (SfN). @janaklab.bsky.social

View the official announcement: www.sfn.org/publications...

11.08.2025 19:44 — 👍 47    🔁 12    💬 0    📌 3

Well said, Rick. I remember covering your groundbreaking work on SYNGAP many years ago for Monitor on Psychology magazine. I fully hope your research endures.

15.07.2025 17:03 — 👍 2    🔁 1    💬 0    📌 0
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🚨 BREAKTHROUGH: UMSOM researchers win $250K NIH prize for tech that delivers CRISPR across the blood-brain barrier. 🧠🧬

Led by Dr. Poulopoulos, the Crisaptics Trans-BBB Team’s work could transform treatment for Huntington’s & glioblastoma.

🔗 bit.ly/44NGUDP

#CRISPR #NIH #Neuroscience #MedEd #MedSky

15.07.2025 22:22 — 👍 9    🔁 4    💬 0    📌 1

Dynamic extracellular interactions with AMPA receptors https://www.biorxiv.org/content/10.1101/2025.07.11.664166v1

14.07.2025 16:15 — 👍 5    🔁 3    💬 0    📌 0
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The winner of OneNeuro's June #FotoFriday #FluorescenceFriday contest was submitted by Victor Omoniyi at the Marie Hardwick and Lauren Jantzie Laboratories. @johnshopkinsmmi.bsky.social

View the complete gallery of OneNeuro BRAINART images here:
www.oneneurojhu.org/...

11.07.2025 13:00 — 👍 8    🔁 3    💬 0    📌 1