kevinbolding.bsky.social

I really enjoy this paper, but I was wondering if there is any demonstration of PV and SOM cells producing different inhibitory dynamics in putative post-synaptic partners.

Anyone know where to find an example of an inhibitory cross-correlogram produced by a somatostatin interneuron? #neuroskyence

YouTube video by 집고양이 김정미 - 추억 (1973 초판), Kim Jung Mi, Memories

youtu.be/JZIv0KV71S4?...

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

This year we ran another meme contest as part of my ML4CCN lecture series. Student submissions were fantastic.

Guess the paper...

Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body Neural representations of sensory stimuli serve multiple distinct purposes, from the rapid recognition of familiar environments, to the precise identification of individual salient cues. In the insect...

Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's @ivychanchiwai.bsky.social findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...

John Cohen, Painter/Collage Artist/Graphic Designer Robert Rauschenberg Preparing for a Show at the Tanager Gallery, 10th St, New York City, 1959.

NSF Implementation of Recent Executive Orders Information for the NSF community regarding executive orders.

NSF’s cash management service is now back up and running.

Seems like they responded to the court order.

new.nsf.gov/executive-or...

YouTube video by CBC News Trudeau: Canada will retaliate with 25% tariffs on $155B of U.S. goods

Here's the speech if you haven't heard it. 13 minutes of your time. Share it with your American friends and neighbours, because they won't see it otherwise. Circulate it in Mexico and Denmark, France and the UK, Panama and Germany, Poland and Estonia, and especially -- especially -- Ukraine.

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Really proud to see my postdoc work out!!

We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging

www.science.org/doi/10.1126/...

The time course and organization of hippocampal replay The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...

1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!

Someone needs to be reaching out to these philanthropies to make it VERY CLEAR that the return on investment from their donations will TANK with NIH and NSF being affected, and that THEIR GOOD MONEY and investment is being being WASTED by these inexcusable (from a business angle) actions.

Sources of philanthropic giving to biomedical science and training programs (graduate and medical school programs, etc.) are NOT going to backstop the loss of NIH, NSF Funding. They aren't able to do so, and many of them may not want attention.

BUT they have sway, and have money in the game.

Opinion | The Devastating Legacy of Lies in Alzheimer’s Science Fraud in research needs to end.

My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)

Painting by Sir Charles Bell depicting opisthotonos, which can be caused by tetanus (1809)

Tetanus on demand! (not for bioweapons, but for neuroscience research)

Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.

To harness this toxicity and use it as a beneficial tool for neuroscience,

Capturing the detail of this monoprint as the writing reveals itself when viewed at an angle.

Writing is from a 1953 letter from my grandad, Francis Crick, to his 12 year old son detailing in simple terms how DNA was a code and how it might copy itself.

#sciart #dna

Latent learning drives sleep-dependent plasticity in distinct CA1 subpopulations Guo et al. find that when mice repeatedly explore a novel environment, a distinct subset of neurons in the CA1 region of the hippocampus, which initially exhibits weak spatial selectivity, gradually d...

🚨Important paper alert (a bit late, but see below)
Guo et al show that while place cells may not initially form a manifold reflecting the environment's topology, the topology is learned across days, during sleep.

www.cell.com/cell-reports...

Another story to tell about this paper 👇
1/5

Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!

The Effect of Olfactory Disorder (and Other Chemosensory Disorders) on Perception, Acceptance, and Consumption of Food People with changes in the overall sensory experience of food often complain of taste disturbances, although the problem is normally caused by the loss of aroma in the food (thus an olfactory disorder...

Alexander Fjaeldstad and I have a new chapter in the book Smell, Taste, Eat: The Role of the Chemical Senses in Eating Behaviour, edited by @LorenzoDStafford. Lots of great insights here.

From our chapter, it’s clear that smell loss and its impact on ingestion remain vastly underexplored."

YouTube video by Dev Limes I Made Good Luck Babe By Chappell Roan Without Hearing It

The reveal of what she created here (the strings, the screamed chorus) had me crying laughing. Truly bonkers.

youtu.be/DwhbnN9hCtI

Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence

Experience-dependent dopamine modulation of male aggression - Nature Dopaminergic neurons in the ventral tegmental area have a role in modulating aggression in adult male mice, and this effect of dopamine depends strongly on fighting experience.

Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.

www.nature.com/articles/s41...

Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal - Nature Communications Hernandez-Trejo, Ciuparu, and Garcia da Silva et al. report that the piriform-to-olfactory bulb feedback in the mouse carries multimodal identity and reward contingency signals, which are re-formatted...

New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...

Does anybody have a favorite Cre recombinase antibody and staining protocol?
#neuroskyence

Alison's work is always worth a look! SST interneurons provide precise inputs to the various dendritic branches of pyramidal cells, as well as providing strong interneuron regulation. Go take a look at this review of their role in cognition and learning!

Question for people going from intan based ephys to neuropixels. Do you have an alternative for the accelerometer from the intan headstage? That was a nice feature that is missing on freely moving neuropixels recordings 🧠📈

A miniaturized microscope mounted on a manipulator projecting line LED light on the surface below.

Episodic and associative memory from spatial scaffolds in the hippocampus - Nature A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.

1/ Super-excited to share our new work “Episodic and associative memory from spatial scaffolds in the hippocampus”, that just appeared in Nature! www.nature.com/articles/s41... Key insights and ideas 👇#tweeprint

Jeff Taube joined Jim ~2 yrs later and, together with Bob Muller, the trio quantitatively characterized HD cells’ tuning curves for the first time (using a 2-spot video tracker!). In 1990, they published their classic papers in the journal of neuroscience.. (2/3)

www.jneurosci.org/content/10/2...