"HLA-independent T cell (HIT) receptor (26), which substitutes the antigen recognition domain of a T cell receptor (TCR) with that of a CAR, thereby co-opting the downstream signaling afforded by the CD3 complex"
www.science.org/doi/10.1126/...
"HLA-independent T cell (HIT) receptor (26), which substitutes the antigen recognition domain of a T cell receptor (TCR) with that of a CAR, thereby co-opting the downstream signaling afforded by the CD3 complex"
www.science.org/doi/10.1126/...
"Assembloids ... are fusion structures that can combine multiple organoid types for the purpose of accounting for inter-regional interactions or can even incorporate missing cell types within the same organoids."
02.03.2026 01:26 β π 0 π 0 π¬ 0 π 0
"Organoids, also referred to as βmini-organsβ, are three-dimensional (3D) in vitro grown structures exhibiting either complete or partial resemblance to in vivo organs in terms of cellular organization, microanatomy and architecture."
pmc.ncbi.nlm.nih.gov/articles/PMC...
iCLAP: integrable Co-detection of Low-Abundant Proteins.
"enables sensitive and highly multiplexed protein detection within the same FFPE tissue section"
www.nature.com/articles/s41...
4i: iterative indirect immunofluorescence imaging.
www.science.org/doi/10.1126/...
IMC: imaging mass cytometry.
"coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass cytometry."
www.nature.com/articles/nme...
t-CyCIF: tissue-based cyclic immunofluorescence.
"conventional low-plex fluorescence images are repeatedly collected from the same sample and then assembled into a high-dimensional representation."
elifesciences.org/articles/31657
CODEX: CO-Detection by indEXing.
Multiplexed DNA-tagged antibody staining.
www.cell.com/cell/fulltex...
There are two nonavalent HPV vaccines, one approved by the FDA in the USA (2014), the other one approved by the NMPA of China (2025).
www.mdpi.com/2076-393X/14...
"hypoxia correlates with immune cell state and organization within granulomas and might subvert immunity to TB"
www.nature.com/articles/s41...
I only knew the transwell assay and the wound healing assay.
08.02.2026 02:25 β π 0 π 1 π¬ 0 π 0
"The median age of patients with HAdV infection was 3 years, with infants aged 0-2 years accounting for the majority (41.39 %)."
www.sciencedirect.com/science/arti...
βintranasal **DNA vaccine** fusing the Mtb ... relMtb with the gene encoding the dendritic cell-targeting chemokine Mip3a/CCL20β
JCI - Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models www.jci.org/articles/vie...
Furthermore, the ratio of activated (CD38+ HLA-DR+) versus exhausted (TIM-3+PD-1+) CD8+ T cells was higher in the early ToD group (Pβ<β0.001) compared with the late ToD group (Pβ<β0.001).
03.02.2026 01:55 β π 0 π 0 π¬ 0 π 0"Over the first four cycles (of immunotherapies), morning circulating CD8+ T cells increased in the early ToD (time of day, before 15:00) group, whereas they declined in the late ToD (after 15:00) group (Pβ<β0.001)."
03.02.2026 01:55 β π 0 π 0 π¬ 1 π 0
TIL:
mtcars |> _$cyl
"x" |> assign(1)
"Human cells and bacteria produce more than 250,000 molecules, or metabolites, as they grow and survive.
**Some of these** can enter the bloodstream, circulate to the lungs and diffuse into exhaled air."
What your breath says about the bacteria in your gut www.nature.com/articles/d41...
One protocol of dual RNA-seq (i.e. host zebrafish and pathogenic Mycobacterium marinum)
pubmed.ncbi.nlm.nih.gov/41564181/
β**whole new dimension of genetically encoded magnetic sensors and actuators**β
β... had make a remote-controlled antibody, which it calls MagBodies, the binding strength of which can be controlled by a magnetβ
βMagLOV's dimming was due to an effect in which the quantum properties of an electron pair in the protein could be altered by a magnetic fieldβ
βfurther improvements (of MagLOV or other fluorescent proteins) should be possibleβ
GFP dims in the presence of a weak magnet (about 1%).
"... engineered a more responsive protein, called MagLOV, the fluorescence of which dims by half or more in the presence of a magnet"
www.nature.com/articles/d41...
The Shingles vaccine has outperformed all expectations. Why?
erictopol.substack.com/p/spotlight-...
"Importantly, ... exploiting distinct properties of a single object for different functions.
Comparable behavior has only been consistently documented in chimpanzees."
Flexible use of a multi-purpose tool by a cow: Current Biology www.cell.com/current-biol...
inserting GSDMDNT sequence along with a heat shock protein (HSP) promoter into OVs (termed GOV), enabling rapid, continuous viral replication through pyroptosis by GSDMDNT expression.
18.01.2026 08:55 β π 2 π 0 π¬ 0 π 0"GOVs were loaded into these donor cells, which were treated with cytochalasin B (CB) and extruded to generate iNV-GOVs"
18.01.2026 08:55 β π 0 π 0 π¬ 1 π 0"Donor cells additionally overexpressed CARs targeting HER2, PSCA, Claudin18.2 or GPC3."
18.01.2026 08:55 β π 0 π 0 π¬ 1 π 0
"Using CRISPR-Cas9, we knocked out Ξ²2-microglobulin (B2M) and the class II transactivator (CIITA) to eliminate HLA-I/II presentation."
"inserted HLA-E and CD47 by homology-directed repair to protect against natural killer cell killing and macrophage phagocytosis."
www.nature.com/articles/s43...
"Thus, the robust efficacy of IV-BCG in SIV+ MCM is retained regardless of anti-BCG drug treatment, indicating that BCG does not need to survive long to provide protection."
"In contrast, SIV control was necessary for full protection induced by IV-BCG."
pubmed.ncbi.nlm.nih.gov/41510269/
Multiple pathways can lead to tuberculosis (TB) disease from opposing immunological extremes.
Anti-PD-1 therapy (almost exclusively in cancer patients), T2D, malnutrition, HIV, some genetic mutations (MSMD), anti-TNF, and more can lead to tuberculosis.
elifesciences.org/articles/108...