Sam Lambert

ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.

Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors

We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org

More info www.omicspred.org/publication/...

Super excited to see beginning integration of PredictDB into OmicsPred!

We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org

More on its way... a wonderful collab with @hakyim.bsky.social & co!

❓Has anyone looked at the overlap between MVP and All of Us? Big enough to worry about when training/testing PGS?

cc @sritchie73.bsky.social @iamslambert.bsky.social

NB: The Polygenic Score Catalog has just lost its NIH funding. It was substantial. We are now on auxillary funding sources.

If anyone has a spare £1m plz DM

From a genomics & bioinformatics perspective, these new NIH policies will likely knock out the pillars of these research fields across the world. No joke. Reseachers everywhere should be aware and **non-US funders need to step up** to fill the big gaps that will appear in the coming months.

My pleasure!

Lots of food for thought about circadian regulation during the #eshg2025 genetic epidemiology session today… 🤔 am I too sleep deprived to understand?

Hasanga presenting at ESHG 2025

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

I meant #ESHG2025, oops!

Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!

Looking forward to the rest of the conference!

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

🚨 Exciting job opportunity for an early career researcher!

Join the Cardiovascular Epidemiology Unit as a Research Assistant/Associate (BHF Scholarship) and explore cutting-edge cardiovascular research!

👉 Apply now tinyurl.com/yc66uz6k

#CardiovascularResearch #PublicHealth #BHF #Epidemiology

We are now on Bluesky!

Follow us to keep up to date with our research and find out what goes on at the Cardiovascular Epidemiology Unit in the @dphpc.bsky.social

#cardiovasculardisease #prevention #healthcare #bigdata #globalhealth #publichealth #riskfactors

@cambridge-ceu.bsky.social!

Are you a new PhD interested in cardiovascular disease, big data, cohorts, or multi-omics? Join our Cardiovascular Epidemiology Unit at the University of Cambridge for a British Heart Foundation-funded postdoctoral position. Open to those not currently in the CVD field. 🔗: buff.ly/R7YJvfl

📢 New publication from the group in @thelancetoncol.bsky.social led by Hend Hasan for her PhD, we used linked EHR + genetic testing data to study 3,400+ BRCA1/2 carriers with history of breast cancer. What happens long-term after BSO?

📄 Paper: www.thelancet.com/journals/lan...
🧵

📣📣 Thrilled to see this cool work finally out in the wild! "Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology & prediction" www.nature.com/articles/s41...

Loads of cool findings including MR for alcohol usage -> increased variance in BC traits

He doesn’t wear enough colourful trousers for a full Portillo-cosplay!

Locus for severity implicates CNS resilience in progression of multiple sclerosis - Nature A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher ed...

I think another problem is how to phenotype severity and worsening, as probably confounded by treatment. There have been hits (MS: www.nature.com/articles/s41...) but I think it required very careful analysis, mortality is somewhat crude.

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/

Flexible funding - many research areas in scope + ideas welcome

Check out our group www.inouyelab.org/home

And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

📣📣 Metabolic reaction fluxes as amplifiers and buffers of risk alleles for coronary artery disease 👉 www.embopress.org/doi/full/10....

Very excited to see this highly innovative study led by @cfoguet.bsky.social finally out in MSB!

Current job vacancy from the Cambridge Cardiovascular network: Clinical Research Associate/ Fellow at the @vpd-hlri.bsky.social www.jobs.cam.ac.uk/job/50854/

Thanks also to @sabramowitz.bsky.social
@mglevin.bsky.social and others at UPenn for sharing tips/tricks that helped develop the documentation.

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

I'm looking for an expert who can speak to the pros/cons of DEXA scans--both for the individuals and at the public health level.

Suggestions welcome! 🧪

Online tutorial Polygenic scores and the PGS Catalog Predicting genetic risks and traits Access anytime, anywhere

We're pleased to announce our latest free online tutorial! This is for anyone who wants to find out more about polygenic scores and how to explore the data in the PGS Catalog: www.ebi.ac.uk/training/onl...

Produced in collaboration with @pgscatalog.bsky.social