An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator. New study from Camille Boutin @camboutin.bsky.social, Laurent Kodjabachian @ibdm.bsky.social @univ-amu.fr and colleagues: rupress.org/jcb/article/...
#Cilia #Technology #Development
25.02.2026 14:45 —
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21.02.2026 16:17 —
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We developed a new cell line that will greatly advance our understanding of #multiciliated cells. With this ressource and thanks to a great collaboration with Jean-Paul Borg, Stéphane Audebert and Luc Camoin we assembled the first MCC proteome;
18.02.2026 20:46 —
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In @jcb.org, @camboutin.bsky.social, Kodjabachian et al. @ibdm.bsky.social describe an inducible multiciliated cell line well suited for advanced #microscopy and #proteomic approaches. The study provides a detailed proteomic profiling of MCC during their differentiation. rupress.org/jcb/article/...
18.02.2026 17:30 —
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@camboutin.bsky.social, Kodjabachian et al. @ibdm.bsky.social describe an inducible multiciliated cell line well suited for advanced #microscopy and #proteomic approaches. The study provides a detailed proteomic profiling of MCC during their differentiation. rupress.org/jcb/article/...
#Cilia
18.02.2026 17:00 —
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System-level regulation of hierarchical transitions in a tumour lineage
The fundamental principles defining how cell state transitions are regulated along a tumour lineage to determine its cellular composition remain unclear. Here, we investigate how such transitions are controlled in a reductionist hierarchical brain tumour model. Quantitative analysis of 3D transition maps revealed that the differentiation of cancer stem cells (CSCs) into transit amplifying progenitors (TAPs) depends on the identity of their immediate neighbours. This is embodied in a transition rule that quantitatively predicts the probability to differentiate as a function of the proportion of TAP neighbours. Integrated into 3D simulations of tumour growth, this rule spontaneously recapitulates spatial segregation of CSCs in clusters and their stable proportion. We further show in vivo that CSC clustering protects the CSC pool from depletion driven by TAPs. We identify an EGFR-mediated relay mechanism that propagates the CSC-to-TAP transition across CSC clusters. In CSCs, the LRIG1-like EGFR inhibitor Kekkon1 dampens this propagation, ensuring continuous replenishment of the CSC pool. Collectively, these findings show how local fate regulation drives emergent segregation which in turn constrains CSC differentiation dynamics. This provides a conceptual framework to understand and exploit the tumour’s intrinsic differentiation potential by manipulating the determinants of its system-level features. ### Competing Interest Statement The authors have declared no competing interest. Turing Centre for Living Systems (CENTURI) La Ligue Contre le Cancer, https://ror.org/00rkrv905, Equipe Labellisée LIGUE 2025 Fondation pour la Recherche Médicale, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Agence Nationale de la Recherche under the France 2030 program, ANR-24-EXCI-0001, ANR-24-EXCI-0002, ANR-24-EXCI-0003, ANR-24-EXCI-0004, ANR-24-EXCI-0005 Centre South-ROCK, INCa-Cancer_18695
Tumours aren’t just a messy mix of cells—they’re highly organised and hierarchical societies!
Just like in all societies, small chats between individuals can drive collective emergent behaviours - we reveal how these sustain tumour growth and cellular heterogeneity. 🧵👇
28.01.2026 21:53 —
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Super happy to share the exciting work of Emma Legait, showing how neighbourhood composition determines cancer stem cell fate in hierarchical tumours. A great and long-standing collaboration with @cedricmaurange.bsky.social
www.biorxiv.org/content/10.6...
28.01.2026 13:54 —
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🧬 The Department of Biology at @univ-amu.fr will soon recruit a lecturer in Molecular Genetics & Genomics (Eukaryotes).
🧪 Apply with an eligible team: Bertrand; Delacour; Kodjabachian; Libé-Philippot; Mann; Schaeffer; Thomas.
Details: lnkd.in/eFS8qQpU
17.02.2026 07:43 —
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Upcoming keynote seminars at IBDM: shorturl.at/YvsbN
We’re delighted to welcome our next speaker:
👉 Meritxell Huch (MPI-CBG)
🗓️ Fri 13/03/2026 · 11:30
📍 Amphi 12
🧫 Tissue-Derived Organoids: Where We Stand and Where We Go
Event page: shorturl.at/XJ4Wz
17.02.2026 07:30 —
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16.02.2026 17:20 —
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🧪 Our Team started to explore a year ago the terra incognita that is the human cerebellum development, cellular structure and evolutionary divergent mechanisms!
🔬 🧠 Let's share the best pictures of this year!
👉 To know more on our work: www.ibdm.univ-amu.fr/team/human-n...
11.02.2026 09:51 —
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To turn spatial data into a 3D object, check our protocol (open source, napari plug-in). @guignardlab.bsky.social @adrianobolondi.bsky.social @ibdm.bsky.social
For example, if you have spatial RNA-seq as sections, you can align them automatically to analyse directly in 3D.
bio-protocol.org/e5607
06.02.2026 14:13 —
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Starting the year socially with a “Winter Before Work” coffee tasting hosted by @centuri-ls.bsky.social ☕️❄️
13.01.2026 09:04 —
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Starting the year socially with a “Winter Before Work” coffee tasting hosted by @centuri-ls.bsky.social ☕️❄️
13.01.2026 09:04 —
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06.01.2026 10:35 —
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06.01.2026 10:35 —
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Fluorescence microscopy image of an ovarian follicle (light blue/magenta), with a bright central oocyte.
💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷
Work on mouse lines + lab logistics + follicle culture/imaging 🔬
🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...
Please share widely — especially with colleagues in France!
06.01.2026 08:13 —
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The CENTURI PhD Call 2026 is still ongoing. Applications are open until the end of the month, on January 28th!
Visit centuri-livingsystems.org/recruitment/ to apply.
#PHD #CENTURI
05.01.2026 08:34 —
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Congratulations, Baptiste! 🎉
27.12.2025 06:55 —
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This week, #axons decided to grow crazy! 💃
Let's find out what's in there that makes them so ready to grow 🧐
Beautiful work from PhD student Pratikhya Acharya 👏 🔬 😎
07.12.2025 13:27 —
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Curious to read about the 'Physical Basis of Sarcomere Assembly'. Here are some thoughts from @friedrich-group.bsky.social and me - you might learn the difference between nematic and smectic order in biological assemblies pubs.aip.org/aip/bpr/arti...
20.12.2025 17:50 —
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Bubble ovaries Christmas lab meeting! 🫧🦑
17.12.2025 15:11 —
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Wow! Very happy that our follicles were selected as one of the winning images for the @sbcf.bsky.social Prix Grand Public 2025! 🙌🏼🪺🤩
20.11.2025 06:39 —
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Congratulations, Baptiste! 🎉
27.12.2025 06:55 —
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🦋 A starter pack of #French universities, #research institutes, and research organizations 🎓🇫🇷
#Recherche #science #scienceOuverte #ESR #HelloESR #CNRS #INSERM #INRIA #ANR #ANRS #OpenScience #Academia #AcademicSky #AcademicChatter #Academics #PhD #PhDSky #EduSky #BlueSky #France #Paris #SciComm
28.01.2025 12:25 —
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📣 Great news from IBDM: three additional research projects have been funded 🎉
These projects will push frontiers in morphogenesis, intestinal regeneration and invertebrate biology 👨🔬
Stay tuned for exciting discoveries 🔬
Learn more 👉 www.ibdm.univ-amu.fr/three-additi...
26.11.2025 15:54 —
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🎓 Congratulations to our 12 new PhD graduates who defended their theses in 2025 at Aix-Marseille Université!
www.ibdm.univ-amu.fr/fr/felicitat...
19.12.2025 12:55 —
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Congratulations, Aziz! 👏
20.12.2025 12:12 —
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Follow IBDM for exciting science on Bluesky: @ibdm.bsky.social 🔬🙌
22.12.2025 12:10 —
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@devdynamics.bsky.social Welcome to Bluesky Developmental Dynamics, added to the Developmental Biology starter pack II.
You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here:
go.bsky.app/M5AgJhn
16.11.2024 23:20 —
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