Lucas E. Sant'Anna

www.biorxiv.org/content/10.1...

Go check out the new preprint from the Daniels Lab! It's been so exciting to see this project evolve 🧪💯

Engineering synthetic phosphorylation signaling networks in human cells Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...

🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....

Orthogonalized human protease control of secreted signals - Nature Chemical Biology Engineering of a human-derived protease controlled exogenously by its FDA-approved inhibitor enables control over cytokine activity in cell-based therapies with reduced risk of immunogenicity.

Paper alert! Really grateful to be part of this project with Dr. Xiaojing Gao engineering cytokine secretion with humanized proteases. www.nature.com/articles/s41...