Michael Angarone

Measles virus and rinderpest virus divergence dated to the sixth century BCE Measles virus diverged from rinderpest virus in the sixth century BCE, indicating an early origin for human measles.

Measles likely came from cows (via rinderpest) around the 6th century BCE.

For 2,500 years, we didn’t evolve superhuman resistance—children just died. Real protection only came in the 1960s, with vaccines.

Our superpower isn’t evolving into superhumans. It’s outthinking pathogens.

One of your investments did not lose a dime today. SOCIAL SECURITY It's the one they want to get rid of...pay attention.

A star cluster within a nebula. The background is filled with thin, pale blue clouds. Parts are thicker and pinker in colour. The cluster is made up of bright blue stars that illuminate the nebula around them. Large arcs of dense dust curve around, before and behind the clustered stars, pressed together by the stars’ radiation. Behind the clouds of the nebula can be seen large numbers of orange stars. Image credit: ESA/Hubble & NASA, A. Nota, P. Massey, E. Sabbi, C. Murray, M. Zamani (ESA/Hubble)

WOW WOW WOW LOOK AT THIS BEAUTIFUL NEW HUBBLE IMAGE OF NGC 346!!! 🌌

Fantastic.

Happy birthday! This was the first X-men I bought as a kid. Love all the Colossus vs Juggernaut issues.

New hardware, who dis? 🤣

Questions for RFK Jr.’s Senate Confirmation: Part II RFK Jr. will soon be asked questions about heading the Department of Health and Human Services. Here are some suggestions.

Questions for RFK Jr.’s Senate Confirmation: Part II
open.substack.com/pub/pauloffi...

Nope. No luck with tasing.

A promotional poster for our first Medical Grand Rounds of 2025! Jan 8 at noon, Drs. Kendall Kling and Teresa Zembower will be discussing "Complex Urologic Infections Program"

Please join us on Wednesday, Jan. 8th at Noon for our first #medicalgrandrounds of 2025! 🍾

We will be joined by Kendall Kling, MD and Teresa Zembower, MD from @nufeinbergmed.bsky.social

#northwestern #northwesternmedicine #nmim #infectiousdiseases #pathology

Though "Oral is the New IV" with antibiotics (h/t @bradspellberg.bsky.social), it's not always easy to convince reluctant inpatient clinicians -- especially (in my experience) surgeons, who want to treat "aggressively".

Interesting dynamic ...
blogs.jwatch.org/hiv-id-obser...

Agree with @bradspellberg.bsky.social it takes time and being persistent. Not backing down, but knowing when to compromise. The transplant surgeons at my place are much more amenable to oral now. And it takes unified messaging from other ID colleagues.

Cervical Cancer | NEJM Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques hav...

Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques have improved survival #idsky #medsky
www.nejm.org/doi/full/10....

Questions for RFK Jr.’s Senate Confirmation: Part I RFK Jr. will soon be asked questions about heading the Department of Health and Human Services. Here are some suggestions.

Questions for RFK Jr.’s Senate Confirmation: Part I
open.substack.com/pub/pauloffi...

Never use to rule I. Or rule out active TB infection. Recently had a case of active TB with - IGRA and another with active M kansasi with +IGRA

🆕🔥Just published 🔥🆕
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB)
An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky
www.atsjournals.org/doi/full/10....

Why even state he is a former sea urchin collector? At least not in the summary statement, maybe a social history.

Big Change in TB treatment recommendations. 6 months of RIPE (also called RHEZ) was once the only treatment in town for susceptible TB. Now there's an all oral FOUR months of:
Rifapentine
INH
PZA
Moxifloxacin
t.co/8EHiWEhEk8

THIS IS HUGE! Researchers at Stanford Medicine have devised an influenza vaccine that prompts immunity to ALL four major flu subtypes AND shows potential against bird flu, indicating a significant advancement in flu prevention and a potential increase in vaccine efficacy. Let’s talk about that! 🧪🧵⬇️

YouTube video by NEJM Group Levofloxacin and Preventing Multidrug-Resistant Tuberculosis | NEJM

Trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with drug-resistant tuberculosis are lacking. Research findings are summarized in a new Quick Take video. youtu.be/5NoUmRlMxs8

#MedSky #IDSky

A Perspective on Vaccinology For many centuries, vaccinology was empiric. Edward Jenner and John Fewster made the observation that those who were often exposed to cowpox were immune to smallpox, and to prove this, they inoculated a young boy with cowpox and demonstrated protection from subsequent smallpox infection.

A Perspective on Vaccinology

#IDSky

Shaping the Future of Infectious Diseases: The Journey to Promote Value, Opportunity, and Positive Messaging To preserve and grow the infectious diseases (ID) workforce, ID professionals should be intentional in using positive messaging to highlight the specialtie

academic.oup.com/ofid/article...

WHO looks back at 2024 Each year WHO takes stock of key moments in health and science over the past 12 months. Here is our review of a very complex 2024. Here’s to a healthier, more peaceful 2025!

WH0 2024 in review:
7 countries ( Brazil, Chad, India, Jordan, Pakistan, Timor-Leste, and Viet Nam) eliminated a neglected tropical disease in 2024, including human African trypanosomiasis, leprosy, lymphatic filariasis, and trachoma.
www.who.int/news-room/sp...

The US military is the most vaccinated segment of the population. They achieved 97% COVID vaccine coverage in 2021 and receive special vaccines pre-employment in addition to standard adult vaccines.
We should aspire to the same levels of vaccination coverage for children in US not less.

This is discussed in wikiguidelines. It is reasonable to not reset if the valve culture from the explant is negative, and it is reasonable to start over if the culture is positive. But there are no data really either way. See WikiGuidelines answer below.

How Much Are Resident Physicians Worth? The University of New Mexico Hospital, Albuquerque, NM. In August 2019, the Accreditation Council for Graduate Medical Education (ACGME) withdrew the accreditation of the University of New Mexico&#…

If you are in medical education OR healthcare leadership, you MUST read this!!! Wow. Just wow.

thesheriffofsodium.com/2022/02/04/h...

Also Big Gun Antibiotics or Powerful Antibiotics

Sweden wants to be the first country to eliminate HPV by 2027 The Nordic country's ambitious timeline relies on high vaccination uptake and efficient mass screening and follow-up treatment.

While US is trying to bring back polio, Sweden is trying to eliminate HPV
"Researchers will start screening to find all pre-existing infections that might cause cervical cancer starting in the second half of 2025" goal is to sample entire population and vaccinate.
www.euronews.com/health/2024/...

Agree, cool. But sure it worked I. This case. Gap many has it failed.