Mathieu Lupien

Our lab website just got a major refresh to better present:

Our research philosophy: why chromatin is central to our work.
A snapshot of our culture: diverse, collaborative, impact-driven.
Our priorities: how we translate discoveries into clinical reality.

Check it out

Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.

One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ

Français : L’image montre un vaste champ de coquelicots rouges éclatants sous un ciel sombre et orageux. Les fleurs, d’un rouge vif, contrastent fortement avec les tons gris et noirs du paysage environnant. Le soleil perce entre les nuages à l’horizon, projetant un rayon lumineux qui illumine certaines fleurs au premier plan. Les coquelicots, aux pétales ouverts et délicats, semblent danser doucement dans la lumière. L’atmosphère est à la fois dramatique et paisible — un moment suspendu entre la tempête et la sérénité, entre l’ombre et la lumière. English: The image shows a vast field of bright red poppies beneath a dark, stormy sky. The vivid red flowers stand out sharply against the gray and black tones of the surrounding landscape. The sun breaks through the clouds on the horizon, casting a beam of light that illuminates some of the poppies in the foreground. Their open, delicate petals appear to sway gently in the light. The overall mood is both dramatic and peaceful — a suspended moment between storm and calm, between shadow and light.

Lest We Forget
N'oublions Jamais

YouTube video by theCrux Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation

DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:

SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200 Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

This acquisition will bring together two pioneering companies with a shared vision: to make single cell analysis more powerful, affordable and accessible to researchers worldwide.

Learn more: bit.ly/4mAWAS8

Climate change, age acceleration, and the erosion of fitness in polar bears Climate change is increasingly disrupting evolved life history strategies and reducing population viability in wild species. Using estimates of epigenetic age acceleration, a cellular biomarker of lif...

Nicely done on the interview. Great to see your work getting the spotlight it deserves! And for those of us looking to dig into the science:

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all.
Regardless, the paper is a must-read:

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

RNA splicing involving poison exons is a whole other world, one I'm all ears to learn about.

DNA mutagenesis driven by transcription factor competition with mismatch repair Competition between transcription factors and mismatch repair machinery drives localized hypermutation at regulatory elements, with implications for cancer and genome evolution.

Nice study showing how DNA mutagenesis can be driven by transcription factor (TF) competition with mismatch repair machinery: www.cell.com/cell/fulltex...
Worth considering alongside the uneven mutagenesis of TF cistromes tied to their cancer-type-specific essentiality: www.cell.com/cancer-cell/...

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

Program Head – Developmental, Stem Cell, and Cancer Biology - Toronto (Region), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 673968 Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute

Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).

jobs.sciencecareers.org/job/673968/p...

YouTube video by University of New England The History and Mystery of Chromatin

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

YouTube video by University of New England The History and Mystery of Chromatin

A jewel of a presentation on the history of chromatin. Always a pleasure to go back in time with those who helped shape it. I am grateful for the insights and stories shared by Drs. Ada and Donald Olins. youtu.be/QExPH1bVbGU

Less than a month to go until the GRC on Hormone-Dependent Cancers! Looking forward to reconnecting with the community and sharing our latest on epigenomics of ecDNAs in tumor evolution. www.grc.org/hormone-depe...

Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity Changes in gene expression regulated by ligand-dependent transcription factors such as estrogen receptor-α (ERα) involves the recruitment of coactivators including p300 that acetylates histone H3 at l...

If you're into super-resolution microscopy, check out the new story from Myles Brown's lab showing how chromatin architecture responds to hormone signaling at enhancers. Dynamic, ligand-dependent changes in H3K27ac structure with implications for endocrine resistance. www.biorxiv.org/content/10.1...

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

My mindset is more that rather than debating with CIHR about in-person versus virtual reviews, we should unite in pushing for a higher payline.

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups!

🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

The July issue of Cancer Discovery is now online! The cover features work by Alexandra Redding, Elda Grabocka, and colleagues on intercellular heterogeneity of stress granules and chemotherapy response - read that and much more here: aacrjournals.org/cancerdiscov...

Raising the payline seems better than IP meetings to improve grant review. At current levels, reviewers culture is shifted on picking one top grant from 8–10. A 25–30% payline shifts the focus to ranking the top ~3, forcing clearer justification of rank order to exclude grant 4,5 and 6.

come join us in our brand new research building!
www.crc.ulaval.ca/wp-content/u...