Ethan Hollingsworth

A call to arms for research universities

"We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."

Opinion | America First? Not When It Comes to Your Health.

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”

We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...

Highlights below!

Exactly 7 years (to the day) after packing my car up and leaving for California, I successfully defended my PhD in the the lab of @evgenykvon.bsky.social!

Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Huge congrats to @gracebower.bsky.social & @evgenykvon.bsky.social on the lab's recent Nature paper! A lot of fun to contribute to this project and watch the story develop over the past several years

Main story of my PhD with @evgenykvon.bsky.social in preprint! See thread and link for all the details!