Damien Glon

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...

🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding?
 NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️

28.05.2025 06:17 — 👍 5    🔁 1    💬 0    📌 2

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates https://www.biorxiv.org/content/10.1101/2025.05.21.655319v1

27.05.2025 08:16 — 👍 6    🔁 3    💬 0    📌 1

Ces recherches ont notamment impliqué des scientifiques de l'Institut de biologie intégrative de la cellule (@i2bcparissaclay.bsky.social - @cea.fr / @cnrs.fr / @univparissaclay.bsky.social / @inrae-france.bsky.social / @inserm.fr), situé à Gif-sur-Yvette (Essonne).
@cnrsbiologie.bsky.social

21.03.2025 08:23 — 👍 1    🔁 2    💬 0    📌 0