Leone Rossetti

📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉

Except a null quadrupole. That can stop us.

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London. Matthias.Krause@kcl.ac.uk
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...

Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation. www.biorxiv.org/content/10.1...

How to turn a layer of fibroblasts into a tulip 🌷?

Check out our new pre-print on shape-programmable living surfaces.

Led by @pauguillamat.bsky.social‬

www.biorxiv.org/content/10.1...

The Idea of Moral Socialism The Idea of Moral Socialism event page

If you always wanted to know what moral socialism is about, now is the time to find out! I am so delighted to be giving this year’s Eva Colorni memorial lecture, joined by Amartya Sen @ LSE. 11th June 5pm, free but registration required. I hope to see many of you there!🌹

Ramya Ranganathan (left) and Andrea Streit (right).

To know more about this work, we spoke to the first author, Ramya Ranganathan, and the corresponding author, Andrea Streit, Professor of Developmental Neurobiology and Head of @ccrb27.bsky.social at @kingscollegelondon.bsky.social:
journals.biologists.com/dev/article/...

Figure 1 Expression of putative Six1 targets.

Unheard candidate genes for deafness-related syndromes

Read this Research Highlight showcasing work from Ramya Ranganathan, Andrea Streit and colleagues @ccrb27.bsky.social @kingscollegelondon.bsky.social:

journals.biologists.com/dev/article/...

Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...

I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...

Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!

New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...

Havana’s streets become racetracks in this exhilarating portrait of children at play | Aeon Videos In this immersive portrait of play, children transform the streets of Havana into a racetrack with handmade ‘chivichanas’

This video takes us to the streets of Havana, Cuba, capturing an exhilarating race of ‘chivichanas’ – handmade carts built from repurposed wood and ball bearings.

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

Recuerda que trabajas 8 horas y no 12 porque unos anarquistas murieron por ello, no porque se les ocurriera a unos fachas saliendo de misa.

Is endothelium a type of epithelium?

I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.

Check out this call for ELBE postdoc fellowships at the Center for Systems Biology Dresden! They are meant for independent postdocs driving theory-experiment collaborations @mpicbg.bsky.social and @mpipks.bsky.social. Please apply before February 14th!

La periodista italiana Cecilia Sala, empresonada en condicions inhumanes a Teheran des del 19 de desembre, ha esdevingut una peça d’una partida internacional entre EUA i l'Iran en què el govern d’Itàlia ha quedat atrapat de forma maldestra. La meva tribuna d’avui:

www.elpuntavui.cat/opinio/artic...

kermit the frog is typing on a typewriter in a messy room . ALT: kermit the frog is typing on a typewriter in a messy room .

📢We're recruiting! Fully funded PhD studentship starting Oct 2025. Interested in #mechanobiology #CancerResearch #Immunology? Awesome project w/
@leonerossetti.bsky.social
&
@koechllab.bsky.social
studying the impact of tissue mechanics on T-cells 👩‍🔬
kcl.ac.uk/dentistry/re.... Deadline 19 Jan

We're recruiting! Please RT. Fully funded PhD project starting Oct 2025. Interested in #mechanobiology #CancerResearch #Immunology? Awesome project w/
@leonerossetti.bsky.social & Eileen Gentleman Lab at KCL
studying the impact of tissue mechanics on T-cells kcl.ac.uk/dentistry/re... Deadline 19 Jan