Leone Rossetti leonerossetti

Home - Engineering Biology For Biomedicine Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...

Interested in a PhD in collective cell migration & mechanobiology?

I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan.

#mechanobiology #PhD
eb4bm.org

26.02.2026 18:15 — 👍 8 🔁 5 💬 0 📌 0

Multiscale Models for Life (MM4L) Centre for Doctoral Training Funded Studentship: How ECM changes shape cellular decision making Embryo, neural crest, developmental biology, cell biology, cell migration, biophysics, mechanobiology, bioengineering.

Fully funded PhD post, UK/Home student, starting 01/06/26. Interested in working at the interface of dev bio, biophysics and cell biology? Great collaboration with Amy Beedle and @leonerossetti.bsky.social Informal enquiries welcome. Deadline 15/03 #neuralcrest

www.kcl.ac.uk/study-legacy...

24.02.2026 22:06 — 👍 8 🔁 11 💬 0 📌 0

I'm very happy to share my first article as a corresponding author published in @natmethods.nature.com !! 😍

Some groups (like us) have developed complex 3DTFM methods in the last 15 years.

BUT its usage in studies that help better understand disease or development has been almost non-existent.

05.01.2026 09:32 — 👍 23 🔁 10 💬 1 📌 2

📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome!
Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉

11.09.2025 09:36 — 👍 22 🔁 8 💬 7 📌 0

Except a null quadrupole. That can stop us.

04.09.2025 10:10 — 👍 2 🔁 0 💬 1 📌 0

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

04.07.2025 10:21 — 👍 60 🔁 22 💬 5 📌 2

Postdoctoral Fellowships The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.

Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London. Matthias.Krause@kcl.ac.uk
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...

04.07.2025 09:16 — 👍 0 🔁 2 💬 0 📌 0

Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis Endocytosis is crucial for various physiological processes, facilitating the uptake of membrane proteins and extracellular material. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A (EndoA), enables clathrin-independent, ligand-induced receptor uptake at the leading edge of cells. Whilst F-actin polymerisation is essential for FEME, how actin dynamics are regulated at sites of FEME is unknown. NHSL1, a member of the Nance-Horan Syndrome protein family, localises to the leading edge of cells, where it regulates migration, and to vesicular puncta, where its function is undetermined. Here, we show that NHSL1 and its uncharacterised family member NHSL2 co-localise and engage in direct, multivalent interactions with EndoA. NHSL1 also binds Ena/VASP proteins, a family of actin elongators. NHSL1 promotes FEME in cells and its interactions with EndoA and Ena/VASP proteins are required for this function. Thus, NHSL1 may cooperate with EndoA and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME. ### Competing Interest Statement The authors have declared no competing interest.

Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation. www.biorxiv.org/content/10.1...

08.07.2025 10:19 — 👍 2 🔁 1 💬 0 📌 0

How to turn a layer of fibroblasts into a tulip 🌷?

Check out our new pre-print on shape-programmable living surfaces.

Led by @pauguillamat.bsky.social‬

www.biorxiv.org/content/10.1...

30.06.2025 17:22 — 👍 117 🔁 29 💬 4 📌 0

The Idea of Moral Socialism The Idea of Moral Socialism event page

If you always wanted to know what moral socialism is about, now is the time to find out! I am so delighted to be giving this year’s Eva Colorni memorial lecture, joined by Amartya Sen @ LSE. 11th June 5pm, free but registration required. I hope to see many of you there!🌹

27.05.2025 19:28 — 👍 77 🔁 18 💬 2 📌 0

Ramya Ranganathan (left) and Andrea Streit (right).

To know more about this work, we spoke to the first author, Ramya Ranganathan, and the corresponding author, Andrea Streit, Professor of Developmental Neurobiology and Head of @ccrb27.bsky.social at @kingscollegelondon.bsky.social:
journals.biologists.com/dev/article/...

14.04.2025 09:58 — 👍 2 🔁 2 💬 0 📌 0

Figure 1 Expression of putative Six1 targets.

Unheard candidate genes for deafness-related syndromes

Read this Research Highlight showcasing work from Ramya Ranganathan, Andrea Streit and colleagues @ccrb27.bsky.social @kingscollegelondon.bsky.social:

journals.biologists.com/dev/article/...

14.04.2025 09:58 — 👍 9 🔁 4 💬 1 📌 0

Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...

28.03.2025 11:46 — 👍 42 🔁 19 💬 0 📌 2

I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...

Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!

25.03.2025 14:37 — 👍 42 🔁 13 💬 1 📌 2

New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...

26.02.2025 09:12 — 👍 114 🔁 39 💬 4 📌 3

Havana’s streets become racetracks in this exhilarating portrait of children at play | Aeon Videos In this immersive portrait of play, children transform the streets of Havana into a racetrack with handmade ‘chivichanas’

This video takes us to the streets of Havana, Cuba, capturing an exhilarating race of ‘chivichanas’ – handmade carts built from repurposed wood and ball bearings.

19.02.2025 13:02 — 👍 8 🔁 1 💬 0 📌 1

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

10.02.2025 16:42 — 👍 29 🔁 13 💬 1 📌 1

Is endothelium a type of epithelium?

I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.

18.01.2025 09:34 — 👍 33 🔁 13 💬 3 📌 4

Check out this call for ELBE postdoc fellowships at the Center for Systems Biology Dresden! They are meant for independent postdocs driving theory-experiment collaborations @mpicbg.bsky.social and @mpipks.bsky.social. Please apply before February 14th!

09.01.2025 15:30 — 👍 5 🔁 1 💬 0 📌 0

La periodista italiana Cecilia Sala, empresonada en condicions inhumanes a Teheran des del 19 de desembre, ha esdevingut una peça d’una partida internacional entre EUA i l'Iran en què el govern d’Itàlia ha quedat atrapat de forma maldestra. La meva tribuna d’avui:

www.elpuntavui.cat/opinio/artic...

07.01.2025 17:30 — 👍 13 🔁 4 💬 0 📌 1

kermit the frog is typing on a typewriter in a messy room . ALT: kermit the frog is typing on a typewriter in a messy room .

📢We're recruiting! Fully funded PhD studentship starting Oct 2025. Interested in #mechanobiology #CancerResearch #Immunology? Awesome project w/
@leonerossetti.bsky.social
&
@koechllab.bsky.social
studying the impact of tissue mechanics on T-cells 👩‍🔬
kcl.ac.uk/dentistry/re.... Deadline 19 Jan

13.12.2024 11:51 — 👍 13 🔁 8 💬 1 📌 1

We're recruiting! Please RT. Fully funded PhD project starting Oct 2025. Interested in #mechanobiology #CancerResearch #Immunology? Awesome project w/
@leonerossetti.bsky.social & Eileen Gentleman Lab at KCL
studying the impact of tissue mechanics on T-cells kcl.ac.uk/dentistry/re... Deadline 19 Jan

12.12.2024 22:16 — 👍 7 🔁 5 💬 0 📌 0

Posts by Leone Rossetti (@leonerossetti.bsky.social)