CuFe Lab

Candidalysin is a fungal peptide toxin critical for mucosal infection - Nature This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membr...

one of the main virulence factors of C. albicans (candidalysin) was found using proteomics of secreted peptides.
www.nature.com/articles/nat...

Effect of increasing concentrations of fluconazole on clinical and lab-generated strains of C. glabrata: the figure shows the effect on drug susceptibility of increasing concentration of fluconazole on different strains of C. glabrata.

Mechanism of azole resistance in Candida glabrata isolates from India: clinical vs. induced perspectives. View the full details in JMM: doi.org/10.1099/jmm....

#JMedMicro

The cover image shows polymeric hydrogel capsules containing slow-release crystals of the colony-stimulating factor-1 receptor inhibitor GW2580 under a polarized microscope.

The new issue of #ScienceTranslationalMedicine is out!

A marker of poor outcomes during invasive candidiasis could inform personalized therapies, a skin temperature study in patients helps answer a longstanding question in narcolepsy research, and more. https://scim.ag/45Ch8n7

Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans METRNL is elevated in candidemia in mice and humans and provides a potential therapeutic target for life-threatening candidemia.

Studying mice and two clinical cohorts, researchers in #ScienceTranslationalMedicine show that the protein meteorin-like worsens outcomes during invasive candidiasis by suppressing antifungal macrophages, suggesting the protein could offer a marker and potential target. https://scim.ag/3LRxWzX

💰Bursaries for Young Scientists
Are you a student or early-career researcher working with yeasts or filamentous fungi? This is for you!
💶 up to €400 to support attendance at the #PYFF9
📍 Valencia, Spain
📅 Application deadline: 30 June 2026.
Apply here👉🏻 yeastfungi.efbiotechnology.org

PYFF Physiology of Yeasts and Filamentous Fungi (PYFF) conference will take place in Valencia, Spain. It brings together researchers from academia and industry who are engaged in the study of the physiolog...

#PYFF9 is coming to Valencia! 🇪🇸
Join us for the 9th International Conference on Physiology of Yeasts and Filamentous Fungi (PYFF9), Sept 8–11, 2026!
✨ Cutting-edge science, vibrant networking, and the charm of the Mediterranean—don’t miss it!
🔗 Learn more: efbiotechnology.org/pyff

Claves que debemos conocer sobre el peligroso virus Nipah La detección de dos casos de infección por este peligroso virus en la India han hecho saltar las alarmas, aunque el riesgo de que el brote se expanda fuera del área afectada es bajo.

Claves que debemos conocer sobre el peligroso virus Nipah
theconversation.com/claves-que-d...

We're happy to announce that our new paper on Cth2 is out!
We show that the Cth2 G195R mutation found in some wild S. cerevisiae strains is important for their tolerance to high iron conditions, while it diminishes their capacity to grow under iron deficiency.
#yeast #iron