Joseph Flynn, MD

Are you on #Medsky yet?

Save our feed and check the pulse of the fastest-growing network of healthcare workers on Bluesky!

Join our fantastic team!

Getting an appropriate amount of exercise, and eating a balanced, kidney-friendly diet are cornerstones of kidney disease management. In this special section of #ASNKidneyNews, explore the role of diet, nutrition, and exercise in fueling kidney health. Explore the articles: kidney.pub/KN-lifestyle

Mid-to-long term outcomes following renal artery angioplasty in children and young adults with renal artery stenosis: a retrospective review
rdcu.be/ez2FP

Defining early vascular aging in youth: an expert consensus ... : Journal of Hypertension he early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/or functional characteristics of the macrovascular an...

Our recent consensus paper on how to define early vascular ageing in youth has recently been published 👇

journals.lww.com/jhypertensio...

You're welcome!

Recent paper by medical student Peter Forster et al. showing an effect of Aminopeptidase A and Angiotensin-(1-12) on BP
@daniel-batlle.bsky.social
@nu-nephrology.bsky.social

Aminopeptidase A Effect on Angiotensin Peptides and Their Blood Pressure Action mdpi.com/3412196 #mdpiijms
@IJMS_MDPI

🔥Paper alert @nature.com. Fantastic 🧪resource for the renal 🫘 community! #NephSky #MedSky

Congrats @puellesv.bsky.social lab and team!

The Spalt-like transcription factor 1 (SALL1) gene is essential for kidney development. Pathogenic SALL1 variants cause Townes-Brocks syndrome 1. Read this Original Article on clinical characteristics of patients w/SALL1-related disorders in Japan. Open Access.
link.springer.com/article/10.1...

Fluid accumulation (FA) is associated w/morbidity & mortality in intensive care. Read this Original Article on the sources of FA in critically ill children admitted to pediatric intensive care.
link.springer.com/article/10.1...

The efficacy of glucocorticoid (GC) in the management of immunoglobulin A nephropathy (IgAN) remains highly controversial. Read this Original Article on the efficacy & kidney outcomes of GC in treating pediatric IgAN.
link.springer.com/article/10.1...

AKI affects 30% of hospitalized pediatric patients, w/high mortality in neonates. Read this Original Article on continuous kidney replacement therapy w/CARPEDIEM® of premature & low birth weight neonates from the French registry.
link.springer.com/article/10.1...

Language preference and acute care utilization in the first year after pediatric kidney transplant
rdcu.be/ew0Eh
@ped-neph.bsky.social

Posterior urethral valves (PUV) are a rare condition leading to CKD & bladder dysfunction. Traditional mgmt can be reactive & non-standardized. Read this Original Article on the impact of standardized care & a dedicated multidisciplinary PUV clinic.
link.springer.com/article/10.1...

Alport syndrome (AS) is a hereditary glomerular disease in children characterized by hematuria, proteinuria, & progressive kidney failure. Read these Clinical Insights into a child w/autosomal dominant AS complicated w/steroid-sensitive nephrotic syndrome.
link.springer.com/article/10.1...

Nadir creatinine value is used as a key predictor of long-term kidney outcomes in patients w/posterior urethral valves (PUV). Read this Original Article on renal perfusion in dynamic scans: a key predictor of long-term outcomes in PUV.
link.springer.com/article/10.1...

Everyone needs to watch this video about the ACIP from the American Academy of Pediatrics:

www.youtube.com/watch?v=pb2E...

Vaccines save lives. They are safe and effective.

And no, they do not cause autism.

Long-term kidney outcomes in children and adolescents with hypertension: a propensity-matched cohort study Children and adolescents diagnosed with hypertension are at greater long-term risk of MAKEs compared with non-hypertensive controls. Improved recognition and control of paediatric hypertension might p...

Childhood blood pressure matters!

Long-term kidney outcomes in children and adolescents with hypertension: a propensity-matched cohort study

www.thelancet.com/journals/lan...

Rituximab is used for steroid-dependent/frequently relapsing nephrotic syndrome, yet parental perspectives on its impact remain understudied. Read this Original Article on parental perceptions of rituximab’s effectiveness, safety, & socioeconomic effects.
link.springer.com/article/10.1...

1/10
Last #NephJC we discussed tacrolimus (TAC) versus mycophenolate mofetil (MMF) for the treatment of pediatric nephrotic syndrome. A first👶to👶immunosuppression study for SSNS in kids #TenPostNephJC .
Read the articles 👇
pmc.ncbi.nlm.nih.gov/articles/PMC...

8/10
#NephJC Quotes of the fortnight
Side effects remain a significant concern for any medication regimen used in children and teens. @jostflynnmd.bsky.social worries about long-term steroids and TAC exposure while @rheaultm.bsky.social opines about the side effects of cyclosporin 🪒

Post-infectious glomerulonephritis (PIGN) is a common cause of glomerulonephritis in children worldwide. Read this Original Article on the epidemiology, clinical presentations, & outcomes of childhood PIGN before & during the COVID-19 pandemic.
link.springer.com/article/10.1...

Children w/X-linked hypophosphatemia (XLH) present w/rickets, leg deformities & growth failure. Read this Original Article on growth dynamics, w/related clinical determinants in children w/XLH treated w/phosphate supplements & vitamin D. Open Access.
link.springer.com/article/10.1...

Read this Original Article comparing the efficacy of desmopressin & enuresis alarm in treating monosymptomatic nocturnal enuresis: a multicenter prospective randomized controlled study.
link.springer.com/article/10.1...

Some shots of blue sky for my Bluesky peeps

We are disgusted that RFK Jr. just wiped out the entire ACIP and replaced its members with people who have pushed dangerous misinformation, including critics of lifesaving vaccines. This is not reform. It is sabotage.

By remaking CDC’s vaccine advisory panel, RFK Jr. is destroying public trust Eliminating ACIP’s expertise on the eve of critical votes about flu and RSV vaccines will delay guidance, confuse clinicians, and cost lives.

By remaking CDC’s vaccine advisory panel, RFK Jr. is destroying public trust www.statnews.com/2025/06/11/r... via @statnews.com

Know a nephrology professional who's making a difference? 😁

Nominate them for an NKF Executive Council Award. Winners receive free SCM 2026 registration.

Deadline: June 30, 2025, Submit a nomination: bit.ly/4lwkBtI
#KidneyHealth #NKFAwards #Nephrology

Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by the dysregulation of the alternative pathway. Read this Original Article on the genetic background & genotype–phenotype correlations in pediatric patients w/aHUS.
link.springer.com/article/10.1...