Francesco Bertoni

Dual targeting of BTK and BCL2 enhances apoptosis in marginal zone lymphoma models: preclinical activity of BGB-16673 and sonrotoclax Background: BTK and BCL2 represent key therapeutic targets in B-cell lymphomas, including marginal zone lymphoma (MZL). Here, we evaluated the novel BTK degrader BGB-16673, and the second-generation B...

Our work on dual BTK and BCL2 inhibition in marginal zone lymphoma, using the new BTK degrader BGB-16673 and the BCL2 inhibitor sonrotoclax, is now available on @biorxivpreprint.bsky.social @iorbellinzona.bsky.social @usi.ch

www.biorxiv.org/content/10.1...

#IORnews
🌊 Researchers from the IOR and the University of Galway in Ireland have identified a new natural compound from Irish marine life showing strong potential against an aggressive, hard-to-treat form of blood cancer.

Learn more: ior.usi.ch/events-news/...

Yesterday we had our first 19-ICML Local Organising Committee meeting — the behind-the-scenes work for the next edition has officially begun! 💥

@frbertoni.bsky.social

#19ICML #ICML #lymphoma #CLL #myeloma #lymssm

-Novel thiosemicarbazones demonstrate pronounced anti-tumor activity in marginal zone lymphoma models, also overcoming resistance to targeted agents
doi.org/10.1158/1535...

-CBP/EP300 inhibitor OPN-6602 in marginal zone lymphomas: preclinical activity as a single agent and in combination with BTK inhibition
doi.org/10.1158/1535...

-Development of isogenic models of marginal zone lymphoma for therapeutic target discovery in TET2-deficient disease
doi.org/10.1158/1535...

Here are the 4 abstracts exploring novel therapeutics for patients with marginal zone lymphomas we're presenting at the #Targets25:
-Epigenetic vulnerabilities in marginal zone lymphoma
doi.org/10.1158/1535...
@iorbellinzona.bsky.social @usi.ch

#IORnews
An international study conducted by the IOR Experimental Hematology Laboratory, led by Prof. Davide Rossi, offers a new perspective on the genetics of classical Hodgkin lymphoma.

Learn more: ior.usi.ch/events-news/...

Polatuzumab vedotin and CD79B: A study of efficacy in R‐CHOP‐resistant diffuse large B‐cell lymphoma Click on the article title to read more.

Our letter by Nicolas Munz on in vitro lymphoma models for polatuzumab vedotin is now online in the British Journal of Haematology. Thanks to everybody at @iorbellinzona.bsky.social @usi.ch @snsf.ch

onlinelibrary.wiley.com/doi/10.1111/...

The Biology of MZL subtypes: Challenge and Relevance of Classification Marginal zone lymphomas (MZLs) are a heterogeneous group of low-grade B-cell neoplasms classified into different entities by the current lymphoma classific

The review article, written in collaboration with Camille Laurent, on the biology of marginal zone lymphomas is now published in Blood. @iorbellinzona.bsky.social @usi.ch Università della Svizzera italiana @snsf.ch

doi.org/10.1182/bloo...

“Recent Advances in Treating Diffuse Large B-Cell Lymphoma “ by Jim Armitage
ascopost.com/issues/june-...

Exploring Resistance to ETS Targeting Agents in Diffuse Large B-Cell Lymphoma Diffuse large B-cell lymphoma (DLBCL) remains a challenging disease with limited therapeutic options beyond standard immunochemotherapy. ETS transcription factors, including SPIB and SPI1, are implica...

A work, by Filippo Spriano in our lab, exploring the mechanisms of resistance to TK216, a molecule that targets ETS factors, is now available in bioRxiv

www.biorxiv.org/content/10.1...

Our collaborative work with Sebastian Patzke and Jostein Dahle on the CD37 targetting radioimmunoconjugated antibody 177Lu-lilotomab satetraxetan (Betalutin) is out in the British Journal of Haematology.
onlinelibrary.wiley.com/doi/10.1111/...

Antimicrobial Peptides Induce Cell Death in Marginal Zone Lymphoma Models Resistant to Targeted Therapies Marginal zone lymphoma (MZL) is an indolent yet incurable B-cell malignancy in which targeted agents such as BTK and PI3K inhibitors frequently fail due to resistance or toxicity. Antimicrobial peptid...

Thanks to a collaboration with Francesco Buonocore and Maria Luisa Mangoni, we explored antimicrobial peptides (AMPs) in marginal zone lymphomas. The initial work by Filippo Spriano and others at the @iorbellinzona.bsky.social, is now available. @usi.ch
www.biorxiv.org/content/10.1...

Screening the Irish Marine Biorepository Identifies a New Bryostatin Analog as Potent Inhibitor of Activated B‐Cells Diffuse Large B‐Cell Lymphoma Bryostatin analogs are found to be accumulated in the nudibranch Antiopella cristata collected in Irish waters. These are found to be potent inhibitors of activated B-cells diffuse large B-cell lymph....

A screening of the Irish marine biorepository identified a new bryostatin analog active in lymphomas. Nice collaboration with Olivier Thomas, his team, Filippo Spriano and other members of our @iorbellinzona.bsky.social lab. @usi.ch @sib.swiss
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Registrations are open for the next LyFE - Lymphoma Forum of Excellence
«What's new in lymphoid neoplasias?», Bellinzona, Switzerland, February 2026
www.lymphomaforum.ch

#IORnews
A collaborative team from IOR, Dana-Farber Cancer Institute (Harvard Medical School), and biotech iOnctura reports that the novel drug roginolisib may boost the effectiveness of venetoclax in blood cancers such as DLBCL, mantle cell lymphoma, and CLL.

Learn more: tinyurl.com/ytybcbr8

Project Hail Mary - Wikipedia

Project Hail Mary by Andy Weir: a very nice reading!
en.wikipedia.org/wiki/Project...

Best Elliott Smith Songs: 20 Essential Tracks The best Elliott Smith songs reflect his ability to wring beauty out of life’s traumas. His prolific output still endures.

Elliott Smith - www.udiscovermusic.com/stories/best...

📣 New ESMO #ClinicalPracticeGuideline on #lymphomas: evidence-based recommendations for all major #lymphoma subtypes, updated as needed as an ESMO Living Guideline, reflecting developments in Tx.
#DLBCL #PCNSL #FollicularLymphoma #HodgkinLymphoma #ESMOGuidelines

🔗 buff.ly/2ZYJc2c

new ESMO Lymphoma Clinical Practice Guideline for diagnosis, treatment and follow-up
www.esmo.org/guidelines/e...

A new postdoc position in our group will open early next year — looking for candidates with a proven track record & relevant experience.

If #CRISPRscreens, #syntheticlethality, #smallmolecules & #celldeath excite you, let’s talk! DMs welcome.

pls share 🙏

Here is a curated list of #patienteducation resources in Simplified or Traditional #Chinese on #health- or #cancer- related topics available from US, UK, EU, Australia, Singapore, Hong Kong, Taiwan, and India. We are curating support groups in US - input needed

blogs.hear2care.org/patientresou...

David Bowie's Best Song From Each of His Albums David Bowie's career reflects a rich evolution in music and persona, showcasing his vast influence across genres from rock to jazz.

“The Best Song From Every David #Bowie Album” by Ultimate Classic Rock: I largely agree but I would have chosen differently from some album. Difficult sometime to select only one song. Bowie is still the best one.

ultimateclassicrock.com/david-bowie-...

The Best Sonic Youth Songs: Alternative Classics Such is the consistency and variety of their extensive catalogue, it's almost impossible to make a definitive best Sonic Youth songs list.

Sonic Youth’s Daydream Nation amazed when they came out and I still listen to it. Wonderful album and band.

www.udiscovermusic.com/stories/soni...

The 10 greatest riffs of Slash's life Slash is one of the most exciting and versatile guitarists in the world, and these top ten riffs prove exactly why that's the case.

Slash’s 10 greatest riffs ever

faroutmagazine.co.uk/slash-10-gre...

Circulating miRNA in lymphomas. The work by Giulia Regazzo from Maria Giulio Rizzo’s group in Rome is out in the BJH. Glad to have contributed. @iorbellinzona.bsky.social @usi.ch

onlinelibrary.wiley.com/doi/10.1111/...

The Jimi Hendrix song that perfected the wah-wah pedal A look at the wah-wah pedal, its history and how Jimi Hendrix perfected its use in one of his best-known and best-loved songs.

faroutmagazine.co.uk/jimi-hendrix...

Pharmacological inhibition of CXCR4 increases the anti-tumor activity of conventional and targeted therapies in B-cell lymphoma models Background: CXCR4 is a chemokine receptor frequently implicated in the pathogenesis and treatment resistance of B-cell lymphomas and other tumor types. Thus, CXCR4 targeting is explored using various ...

Our very interesting work on CXCR4 inhibition to increase the activity of therapies in B-cell lymphomas is now available in bioRxiv. Thanks to Laura Barnabei, Alberto Arribas, and all the contributors. @iorbellinzona.bsky.social @sib.swiss @usi.ch

www.biorxiv.org/content/10.1...

I have never watched Doctor Who, but I alway listen to Lee Scratch Perry🙂