Manuel F. Navedo

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for acce....

Check out our reviews on "Translating cardiovascular ion channel and Ca signalling mechanisms into therapeutic insights". Massive effort from junior investigators, emerging researchers & other leaders in the cardiovascular field. @ucdavis.bsky.social

doi.org/10.1113/JP29...

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties Abstract figure legend Amyloid-β1-42 (Aβ1-42) triggers a male-specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway invol...

Just in time for the Holidays, our latest paper on how #amyloidbeta regulates the spatiotemporal properties of vascular L-type channels - implications for vascular function.

Great work by Jade and team! @ucdavis.bsky.social, @ucdavishealth.bsky.social

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory Dopamine-induced phosphorylation of an L-type Ca2+ channel supports working memory in mice.

Great way to start the final month of the year with the publication of this collaborative work on how dopamine regulates L-type channels in #neurons.

www.science.org/doi/10.1126/...

And we got the cover!!! @ucdavis.bsky.social, @ucdavishealth.bsky.social

Happy Halloween and Happy Fluorescence Friday 🎃✨

#ScienceCostumes #FluorescenceFriday #SuperResolution #PALMSTORM #LabLife

Postdoctoral Scientist - Zhang Lab Primary Work Address: One Shields Avenue, Davis, CA, 95616 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and s...

🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩
More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia - PubMed These results suggest a key role for Panx1 in controlling ATP signaling through the P2Y_11L/AC5/AKAP5/PKA/Ca_V1.2 axis in arterial myocytes. This Panx1-led complex modulates cAMP levels, Ca_V1.2 activity, and vascular reactivity in response to diabetic hyperglycemia. Th …

The third episode of our podcast series just dropped:

navedolab.faculty.ucdavis.edu/podcasts/

This one focuses on our recent study examining vascular Panx1 channels and their role in vascular complications during diabetic hyperglycemia.

Get the paper here:

pubmed.ncbi.nlm.nih.gov/40636957/

Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar. Welcome! You are invited to join a webinar: Unlocking vascular disease connection through ion channel signaling. After registering, you will receive a confirmation email about joining the webinar.

Excited and honored to present this webinar. Please join!

🎙️Webinar!
Unlocking vascular disease connection through ion channel signaling

🗓 September 29th, 2025
🕒 Time: PDT 17:00 / CDT 19:00 / EDT 20:00
Register: tinyurl.com/yoluxuwf
#VascularDisease #IonChannels #Webinar

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social

www.ahajournals.org/doi/10.1161/...

A little bit late but I’m honored and humbled to have been selected back in May as the recipient of the 2025
@ucdavis.bsky.social, @ucdavishealth.bsky.social Research Award! This recognition belongs to the M&M Lab members!

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF

Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social

Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity Lee et al. show that OCT3 and PMAT transport norepinephrine (NE) into neurons to stimulate β2ARs that are in their interior. The ensuing phosphorylation of GluA1 on S845 by PKA drives AMPARs to the su...

Great way to start the week with the release of this collaborative work with students and Drs. Horne & Hell
@ucdavispharm.bsky.social, @ucdavis.bsky.social. Get your copy now!

www.cell.com/cell-reports...

Thank you for all the help and support! This story could not have happened without your timely and exeptional research skills and knowledge of the field. Much appreciated!

Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...

United in discovery, stronger together!!! Great science happens when we gather to learn, support each other, & celebrate the power of collaboration & community at our Departmental Annual Retreat!

Shout out to organizers Deborah, Elva, Nate, Hai, Matthew, Christina & Charlotte!

YouTube video by UC Davis Graduate Studies My 100: Jeffrey Hill, M.S. '79

Discover the inspiring story of Jeff Hill, a
@ucdavis.bsky.social alum who leveraged the training he received in #physiology to support USA Air Force pilots.

MCIP provides the training so more people follow on Jeff's steps.

youtu.be/KuM4RIB98T8?...

Oh these amazing things!!! Will need to place an order for deliver to Cali 😅

The second episode of our podcast series just dropped.

navedolab.faculty.ucdavis.edu/podcasts/

This one highlights efforts of the Nieves-Cintron group to understand the effects of nicotine and tobacco products on vascular function.

Check out the paper here:

pubmed.ncbi.nlm.nih.gov/38805589/

🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by
@vesselman.bsky.social

🧠🧪 Check it out: www.science.org/toc/signalin...
@cuanschutz.bsky.social

Honored and humbled to have received the Berne Distinguished Lectureship Award from the @apsphysiology.bsky.social CV Section this past weekend. Thanks to all current and former M&M Lab members, collaborators, @ucdavis.bsky.social, @ucdavishealth.bsky.social, #NIH_NHLBI & @americanheart.bsky.social

A great start to the Basic Sciences Symposium celebrating Women’s History Month! Keynote speaker Dr. Martina Anto-Ocrah with event organizers! @roseedixon.bsky.social @hannahvoorhees.bsky.social @ucdavis.bsky.social

Premier Episode UC Davis PMB—Physiology Talks · Episode

We’re excited to announce the launch of our new PMB podcast on Spotify, titled Physiology Talks. This channel utilizes AI podcasters and is designed to showcase the incredible research happening in PMB @ucdavis.bsky.social . Tune in to the Premier episode!🎤🔬
open.spotify.com/episode/1LwV...

α1C S1928 Phosphorylation of CaV1.2 Channel Controls Vascular Reactivity and Blood Pressure - PubMed Results suggest an essential role for α1_C S1928 phosphorylation in regulating channel distribution, activity and gating modality, and vascular function during angiotensin II signaling and h...

The paper that is the subject of this podcast can be found here: pubmed.ncbi.nlm.nih.gov/39377203/

We are trying something new to help our community understand the impact of the science they generously support.

Check out Episode 1 of a new podcast series: navedolab.faculty.ucdavis.edu/podcasts/

Disclaimer: generated by AI, but I think you will thank me as I will be terrible at this 😆

Thanks for actively participating and supporting the symposium, and for the visit. Always awesome to see you!

Great audience and energy as we start the 8th
@ucdavis.bsky.social Cardiovascular Symposium!!!

Excited to share this comprehensive review paper by Department Faculty on mechanotransduction in the #heart!
@ucdavis.bsky.social

The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect | Annual Reviews - go.shr.lc/42PlLtB

Faculty is on 🔥 this week! This comprehensive review highlights sex differences in the #heart!
@elegrand.bsky.social, @ucdavis.bsky.social, @ucdavishealth.bsky.social

Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation | Annual Reviews - go.shr.lc/3UpL3cq

We are proud to host the 8th @ucdavis.bsky.social Cardiovascular Symposium Feb 13-14th!!! basicscience.ucdmc.ucdavis.edu/UCDavisCardi...

If you want to join us via webcast, please use the following link to register: na.eventscloud.com/ereg/index.p...

Electrifying the brain capillary Ca2+ signal | PNAS Electrifying the brain capillary Ca2+ signal

Check out this editorial written for a beautiful work by MArk Nelson's Lab on electro-calcium coupling and control of the neurovascular unit.

www.pnas.org/doi/10.1073/...