Alex Guseman

but the whole point of the apollo program was to work on rocket booster technology for ICBMs.... Did his teacher ever ask what his dad did in the military?

1.) be patient getting started takes time
2.) every time in the 1st 6mo a colleague asks to get coffee do it.
3.) it’s a marathon not a sprint.
4.) you will make mistakes it’s fine
5.) there’s a lot of this we were never trained for.

I know of a lot of high powered magnets in Pittsburgh…. But I didn’t know I could use them to move furniture !!

Pretty cool. With help from some friends modified a 3D printer to make a fraction collector. It cost $200$ instead of 1500$ works perfectly.

🐧🐧🐧🌸🌸🌸🐧🐧🐧
Thank you Marc Andre for all the memories!!!! (Picture courtesy of Father in law)

"d0nT w0rRy Gr0k c@n d0 iT"-19 year old doge employee, probably.

any if they are shutdown past the submission deadline then they could be considered late/ missing the deadline?

WAIT. this is my first time. Do i need to get it submitted BEFORE the government shuts down?

anyone ever have a cytiva column valve confuse upflow and downflow?

fairly sure the answer is yes. but also idk how.

NMRSky! Is there any way to indicate multiple peak assignments for a single spin system (I.e., exchange where two peaks for one amide are visible) in a BMRB deposition? @nmr900.bsky.social

Thanks!

anyone else seeing insane tarrif charges? 24% more expensive?!?!

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

talk about the most expensive GMO-pork chop!

In addition the "in-cell" spectra look to clean to truely be in-cell. Now i have never done RNA in-cells but As a Pielak PHD and Gronenborn Postdoc who did in-cell NMR in each lab I can comment that these spectra are very suspect to me.

look at these supernatant controls...they saw leakage in their post and just scrolled down in intensity to try to flatten it out. I have NEVER seen an NMR spectrum without resonances look that much like a flat line and then on top if you look at where the deviations from flat correlate with peaks

Me: Ugh i shouldn't have agreed to review this manuscript it does not match the abstract and is going to be a lot of work when i should be writing a grant...

Also me: oooo invitation to review another manuscript that I know is going to be interesting...✅

*sigh* at least this 2nd one will be easy

this is why I'm glad I don't watch/read the local news... as someone whose lab works a bit on dengue i probably should know its in SD lol

haha Sorry! tbf i checked to see if you had made it already!

word from RFK Jr is that cataracts are due to mitochondrial stress in the eye lens!

bravo Juan. keep up the good work!

Oh man. And during talks. I had a hype man in the audience for me during my last talk and he left before I got to thank him.

How the fuck am I supposed to plan my lab finances if my grants keep getting terminated and reinstated and terminated again?

End rant.

Want to attend #bps2026 in San Francisco but need help with funding to get there? BPS offers travel awards for students and scientists at every career level.

Deadline to apply is October 3
(and you have to submit your abstract by October 1!)

UCSD is holding a town hall with @repscottpeters.bsky.social this Wednesday to urge him to oppose proposed research funding cuts in the FY2026 budget, set for a vote in September. Please RSVP below and share widely. Everyone is welcome.
form.laborbase.org/251675765832...

anyone have bead bath bead suggestions that are affordable?

Or any hacks, can I go to wally world and by 500 worth of BB gun ammo (on my p-card) thats made of the same material?

This work of course was done by two talented members of the Guseman Lab, Sabrina Richter our former all star tech who just left us for grad school at UC-Berkeley and it was started by the Neal Brook during their summer rotation last year. I am sure this is the first of many stories from them!

Our data suggests that the glycocalyx could be able to modulate the energy landscape between these states and thus influence cell signalling. Given the dynamic nature of the glycocalyx and its ability to remodel itself as response to stimuli/cell stress. This is an exciting ave for future study!

These results demonstrate the glycopolymer components of the glycocalyx can tune stability and interactions of proteins by acting as macromolecular crowders. Contextually, many of the proteins that reside in the glycocalyx are involved in signalling and exist in inactive state A and active state B.

Switching next to protein protein interactions, we used arguably my favorite protein A34F GB1 to demonstrate that these glycopolymers stabilize protein protein interactions in a similar fashion to protein folding, via chemical interactions.