Clinical Gastroenterology and Hepatology

✴️The March issue of #CGH is now online! This issue includes:
🔸A study on the effect of weight loss on patients with Gastrointestinal & Liver Disease
🔸A review on wearable technologies in #IBD
🔸Research on neoplasia detection rates
🔸...And more!
🔗: https://ow.ly/HeGe50Ym6VX

🌟CVE provides a means for automated ulceration and mucosal injury quantitation that shows conceptual agreement with SES-CD. CVE offers new capabilities to improve the granularity and personalization of endoscopic disease assessment in CD.

🔗: https://ow.ly/kmpw50YhhoM

A growing body of evidence suggests microplastics & nanoplastics may affect GI and liver health. A comprehensive @AGA_CGH review found microplastics linked with inflammation, gut dysbiosis, liver disease and possibly GI cancers ➡️ https://ow.ly/j41w50YhkmU @dutta_priyata @AGA_GIHN

‼️New data show acne is a common and impactful side effect of JAK inhibitors in IBD—highlighting the need for early recognition and proactive management.

🔗: https://ow.ly/szta50YhgEN

@Sash_Honap @PeyrinBiroulet @ibdseb @eathar_s @shahidadin1 @TakuKobayashiM1 P7278 @PolychronisP

🧬“Distal eosinophilia predicts PPI response in EoE, while proximal‑predominant patterns predict nonresponse. Distribution may reflect distinct phenotypes and guide care.”
@walterchanmd @mayssanmuftah

🔗: https://ow.ly/tHtp50Y8M0J

🗣️"Patients with both adenomas and significant serrated polyps face a higher risk of advanced neoplasia than those with either alone. They may benefit from shorter colonoscopy surveillance intervals than current guidelines recommend."

🔗: https://ow.ly/UMmf50Y8Lig

🛎️"Dynamic FIB-4 changes are linked to liver fibrosis progression and adverse outcomes in MASLD. Regular monitoring may support early risk detection and management."

🔗: https://ow.ly/k6vc50Y8KKB

✅"Global cohort of inpt #cirrhosis with external validation showing bili, INR cutoffs for defining liver failure & important impact of #infections & #HE"

🔗: https://ow.ly/tbFM50Y8KBH

🗣️New research found pediatric-specific cutoffs for the fatty liver index and hepatic steatosis index to help diagnose MASLD. These markers may improve early detection and risk stratification of MASLD in youth

🔗: https://ow.ly/PVG850Y52aZ

💡NILDAs are effective alternatives to liver biopsy for fibrosis assessment in MASLD and may serve as a tool to identify patients who are candidates for newer therapies.
@RichSterlingMD

🔗: https://ow.ly/LIr950Y51kR

🚨 The newest issue of #CGH is now available! Check it out!
🔗: https://ow.ly/Eu5T50Y4WyG

‼️This new #CGH article observed HCC incidence rates declined and mortality plateaued in the US!
📰 Check out the press coverage: https://ow.ly/2JsR50Y0RpM
📝 Read the article: https://ow.ly/wQEr50Y0RpN

🛎️AMR is rising in patients with cirrhosis. Multidisciplinary effort is crucial to combat AMR and manage bacterial infections in cirrhosis.

🔗 Read More: https://ow.ly/aMJS50Y0Ep0

🧬Etrasimod shows strong induction & maintenance efficacy in moderate–severe endoscopic UC, with potential continued improvement beyond 12 weeks—promising news for patients and clinicians.
🔗 Read more:https://ow.ly/YcVz50Y0Efj

💠New #CGH article on Night-shift workers showing a strikingly high prevalence of IBS and functional dyspepsia.
📰 Check out the press coverage: https://ow.ly/MGJI50Y0R8z
📝 Read the article: https://ow.ly/EqzV50Y0R8A

💠New #CGH article on Night-shift workers showing a strikingly high prevalence of IBS and functional dyspepsia.
📰 Check out the press coverage: https://ow.ly/tWJb50Y0R3r
📝 Read the article: https://ow.ly/q8OS50Y0R3q

📱Among 654 participants offered both tests, 55% used the smartphone FIT (76% valid) and 98% used the lab FIT. Overall, 89% found the smartphone test useful. Main reasons for not using it were technical issues or general concerns. Sensitivity matched the lab FIT.

🔗: https://ow.ly/2N3B50XWI7H

💭nCPAP reduces hypoxia risk and stabilizes O₂ levels in patients with obesity during sedated upper GI endoscopy, supporting its routine use in high‑risk patients. More studies should explore wider clinical use.

🔗: https://ow.ly/K83M50XWHN3

💡In a large U.S. community cohort, concomitant and bismuth quadruple therapies had the highest H. pylori eradication rates for initial treatment with no major decline over time. Bismuth quadruple was also the most effective salvage regimen.

🔗: https://ow.ly/53Ir50XWHwu

✅Dosing based on proactive TDM was superior to clinically based dosing in terms of EH in a randomized controlled trial of pediatric CD.

🔗: https://ow.ly/Qqop50XWHjw

💊Dosing based on proactive TDM was superior to clinically based dosing in terms of EH in a randomized controlled trial of pediatric CD.

🔗: https://ow.ly/PYUy50XSVNK

💡#RCT in cirrhosis: 6-mm TIPS lowers overt HE risk vs 8-mm, but increases rebleeding. Survival similar for both. Choosing the right size matters!

🔗: https://ow.ly/X6w450XSVzA

💠In patients with dACLD, copeptin is independently linked to systemic inflammation. The MELD-copeptin score identifies patients with dACLD at risk for impaired clinical outcomes.

🔗: https://ow.ly/XBi750XSV7b

✅Metabolic comorbidities are linked to more severe liver fibrosis in untreated CHB patients and to less regression—or even progression—of fibrosis despite antiviral therapy.

🔗: https://ow.ly/eTXb50XNbF7

➡️Dysregulations in the brain-gut-microbiome (BGM) axis as a result of SDOH contribute to changes in the gut microbiome, hypothalamic-pituitary-adrenal signaling, and the brain’s reward network, leading to altered ingestive behaviors and obesity.

🔗: https://ow.ly/XCr350XNb6e

🚨 The January issue of #CGH is now online! This issue includes:
💠A study on biopsychosocial & environmental factors that impact BGM interactions in obesity
💠 Performance of a smartphone-based stool test for use in #CRC screening
💠 ...and much more!
🔗https://ow.ly/QWbk50XNauQ

New in CGH🚨: What’s the yield of advanced neoplasia at the second post-polypectomy surveillance colonoscopy? A systematic review and meta-analysis offers key insights for risk stratification and follow-up strategies✅

🔗: www.cghjournal.org/article/S154...

🤖GEMA-AI made more accurate predictions of waiting list outcomes than the currently available models, and could alleviate gender disparities for accessing LT.

Read more here➡️:https://ow.ly/15s550XjGH7

🗣️Compared with non-IBD elderly, patients with #EO-IBD have similar risks for death and complications. Compared with AO-IBD, patients with EO-IBD are at higher risk for abdominal surgery, but not for perianal surgery. Read more here🔗: ow.ly/I0qt50XbJ0l

🔎Around 1 in 4 people with CCA have chronic liver diseases, and 1 in 10 have cirrhosis.
Read more here: ❇️ ow.ly/GIh450X2qc0