MUSC Youth Collaborative

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How much is enough? Assessing 30‐ versus 60‐day Timeline Followback stability in youth alcohol use patterns Variability of youth alcohol use is thought to necessitate longer Timeline Followback (TLFB) reporting windows. This study assessed youth (N = 481, ages: 15–25) alcohol use patterns across two differ....

onlinelibrary.wiley.com/doi/10.1111/...

Team members Drs. Kirkland, Ferguson, Tomko, and Squeglia, with Tirza Alcala and @louisemewton.bsky.social (University of Sydney), published one of the first papers using Entryway data, finding that a 30-day recall window is sufficient and less burdensome for assessing youth alcohol use patterns.

Variations in alcohol craving and negative mood during a clinical trial of ibudilast for alcohol use disorder Neuroimmune compounds are being investigated as novel treatments for alcohol use disorder (AUD). This secondary analysis of a randomized clinical trial of ibudilast for AUD (N = 102) evaluated change....

onlinelibrary.wiley.com/doi/10.1111/...

Dr. Lindsay Meredith and UCLA collaborators found that ibudilast, an anti-inflammatory medication, reduced alcohol craving in a 12-week trial for alcohol use disorder. Women may respond more strongly to immune-based treatments. Read more in @acerjournal.bsky.social

#Research #MUSC #UCLA

The alcohol cue‐exposure paradigm as a screening tool for alcohol use disorder medication development: A critical review The alcohol cue-exposure paradigm has a long history in alcohol use disorder (AUD) research. This review examined the paradigm's utility as a screening tool for AUD medication development and offers ...

Last fall, Dr. Lindsay Meredith participated in a scientific meeting in Washington D.C. on alcohol cue exposure paradigms. This paper outlines recommendations to enhance their use in lab studies testing new medications. @acerjournal.bsky.social

Read here 👉 onlinelibrary.wiley.com/doi/10.1111/...

Our NIH-funded trial found N-acetylcysteine (NAC) reduced alcohol use in youth with moderate–severe AUD, but not mild AUD, suggesting NAC’s potential as adjunctive treatment. Published in @jaacapjournals.bsky.social

Read here 👉 tinyurl.com/4t5f9jj9

#AddictionResearch #ClinicalResearch #NIH #MUSC

Thankful for our @matildacentreusyd.bsky.social collaborators: @louisemewton.bsky.social & @rvisontay.bsky.social

Oral microbial profiles in young adults with cannabis use disorder With increasing legalization and rising potency of cannabis products, cannabis use disorder (CUD) is a growing public health concern, particularly amo…

www.sciencedirect.com/science/arti...

New paper in @drugalcreports.bsky.social: @brittneydawn.bsky.social, Tomko, Kirkland, Ferguson, Squeglia et al. report cannabis use disorder is linked to reduced oral microbiome diversity & unique bacterial patterns, especially with heavier use.
#AddictionScience #Microbiome #MUSC #Cannabis

A multimethod examination of impulsivity and its association with gamma-aminobutyric acid (GABA), glutamate, and other neurometabolite levels in youth who do and do not use alcohol Minimal research has examined neurochemical alterations underlying the relationship between impulsivity and alcohol use in youth. We examined associat…

Led by Anna Porter (Mizzou), new study combines Dr. Squeglia’s K23 & R21 data to examine impulsivity, neurometabolites & alcohol use in youth. Results: self-reported impulsivity ↑ in alcohol users; glutathione may modulate this link. Read 👉 tinyurl.com/4drd5tda
#Neuroscience #YouthResearch

Thank you for hosting us!

YouTube video by NPP Journal npp's "Meet the Author" with Dr. Anna Kirkland

Dr. Anna Kirkland was featured in @npp-journal.bsky.social Meet the Author series with @drfriid.bsky.social, discussing her recent trial: “Neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder.”

📺 Watch: youtu.be/2J6GFCMtXcE?...

#AddictionResearch #ClinicalTrials

Hi @bsky.app! 👋 We’re the MUSC Youth Collaborative. We study how substance use affects the developing brain and work to turn research into practical education and prevention programs for young people. Excited to share our work and connect with you here!
#Neuroscience #YouthResearch #ScienceEducation