Jeremy Jacobs, MD, MHS, FASCP

New Opinion article by @jwjacobs12.bsky.social and Shazia Khan: "Erasing the evidence: United States climate rollbacks and the implications for public health"

journals.plos.org/climate/arti...

Blood Borders: State laws, vaccine misinformation, and the threat to the United States blood supply Click on the article title to read more.

Blood is shared across legal borders to save lives.

Equitable and efficient movement of blood is guided by science and justice and must be insulated from ideologically motivated practices, argue co-authors @jwjacobs12.bsky.social @aabbupdates.bsky.social

onlinelibrary.wiley.com/doi/10.1111/...

In this Nature Medicine commentary @drgsbooth1.bsky.social and I discuss how the current political environment in the USA, including the weaponization of immigration enforcement, is impacting global scientific research, and the implications for science.

www.nature.com/articles/s41...

This analysis reflects the recommendations and expertise of an international group of leaders in blood transfusion, biomedical ethics, health policy, and law. @transfusion.health @aabbupdates.bsky.social @isbt.bsky.social

Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025 | Annals of Internal Medicine In the United States and other high-income countries, blood donation primarily relies on anonymous, voluntary donors. However, directed blood donation—where people donate for a specific recipient—has ...

🩸Would you want “unvaccinated” blood? Some patients now demand it—and lawmakers are listening.

Our new Annals piece warns why this shift could endanger blood safety, amplify misinformation, and erode public trust.
Read: www.acpjournals.org/doi/10.7326/...
#BloodSafety #Bioethics #Misinformation

In other words, the US government has suspended free speech.

Check out our recent viewpoint in @jama.com. The appointment of David Geier to lead the “vaccine and autism link” study, the forced resignation of Peter Marks at the FDA, and the overall leadership of RFK Jr. and Trump are literally killing Americans. We must resist this new world.

The Health Secretary is promoting quack doctors in the midst of a measles outbreak and literally nothing was more predictable.

Here is an open letter signed from UChicago AAUP signed by over 200 faculty to our administration on what we believe this moment requires:
uchicagoaaup.wordpress.com

EU foreign policy chief:

“.. Today, it became clear that the free world needs a new leader.”

@kajakallas.bsky.social

Transfusion Strategies in Myocardial Ischemia — Treat Patients, Not Numbers Consider a relatively common clinical scenario: a 55-year-old man arrives in the emergency department after experiencing crushing retrosternal chest pain while shoveling the first snowfall of winte...

In this issue of NEJM Evidence, @jwjacobs12.bsky.social and I interpret the recent individual-patient meta-analysis for RBC transfusion in myocardial infarction by Carson et al and make a case for nuanced interpretation evidence.nejm.org/doi/full/10.... #medsky #transfusion

H and B Blood Antigens are Essential for In Vitro Replication of GII.2 Human Norovirus Human norovirus (HuNoV) is a major cause of enteric infectious gastroenteritis and is classified into several genotypes based on its capsid protein amino acid sequence and nucleotide sequence of the polymerase gene.

H and B Blood Antigens are Essential for In Vitro Replication of GII.2 Human Norovirus

✅ Just Accepted
#IDSky

Screenshot of correspondence with @natureportfolio.bsky.social advocating that all scholarly journals support direct link-sharing to Bluesky amidst the exodus of many academic communities from X (formerly Twitter)

Our correspondence with @natureportfolio.bsky.social advocating that scholarly journals support direct link-sharing to #Bluesky amidst the exodus of academic communities from X (formerly Twitter)

@drgsbooth1.bsky.social @jwjacobs12.bsky.social @path-brian.bsky.social

www.nature.com/articles/d41...

Wow I had no idea! I feel like we all look to y’all as the gold standard. Hopefully one day with AI we will be able to have the ability to access antigen genotype or at least alloantibody status irrespective of country borders

Basically I always invoke Canada as the standard the US should aspire to regarding alloantibody databases, so let me know if should pick a different example 😅

I thought Canada outside of Quebec (and Quebec itself) had an alloantibody registry? Or is this just for certain patient populations (eg sickle cell disease)? Completely agree that even with ‘low’ alloimmunization rates, the issue is knowing about them once they evanesce. Cool study!

Evaluating the potential for iodinated radiocontrast agents to interfere with ADAMTS13 activity testing via fluorescence resonance energy transfer methodology AbstractObjectives. Fluorescence resonance energy transfer (FRET)–based ADAMTS13 activity assays are critical for the diagnosis of thrombotic thrombocytope

Excited to share our recent study in which we assessed whether iodinated radiocontrast media (as might be given for a CT scan) interferes with ADAMTS13 activity via the gold standard FRET method - it doesn’t, though read the open access paper for caveats. academic.oup.com/ajcp/advance...

Tranexamic acid did not prevent bleeding or increase clotting in this ~600 patient RCT of heme malignancy patients (TXA was given 1 g IV every 8 hours or 1.5 g orally every 8 hours)🤷🏽‍♂️

Which is too bad--we don't have a tonne to offer these patients.. :(

www.thelancet.com/journals/lan... #transfusion

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Good news, Altmetric has now started watching BlueSky for mentions of publications. And by the way, provides an easy comparison between this and the old site for a recent preprint of mine which I posted simultaneousl at both. Numbers speak by themselves !

🩸Platelets!

Lifespan 7-10 days
150-450 × 10⁹/L
Stimulated by TPO
1/3 sequestered in spleen

Receptors:
GpIIbIIIa -> fibrinogen
GPIb-IX-V -> vWF
P2Y12 -> ADP

Granules:
Alpha = fibrinogen, vWF, V, VEGF, PF4, PDGF, P-selectin
Dense = ADP, Ca, Serotonin
#hemesky #MedSky

van der Meijden et al, 2019

Wonderful article by my mentor showing cognitive biases persist in AI chatbots, replicates known studies on biases in human and AI LLMs for comparison. Evidence that LLMs are inheriting some of our biases, in some cases quite strongly so ai.nejm.org/doi/full/10....
#mlsky #ai

Advocating for @altmetric.com to include #Bluesky in its tracking
@drgsbooth1.bsky.social @sraza.bsky.social @path-brian.bsky.social

😂

Would love to be included!

A fantastic person/physician/researcher to follow!

How do we screen for hemoglobin abnormality in the US?
-All state newborn screens evaluate hemoglobin
-pediatric-age immigrants often get newborn when they come to US
-Thalassemia trait often identified in pregnant patients or patients with persistent microcytosis after correcting iron deficiency

The best girls