Ines Patop

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Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

This is so cool!

Summer 2025 Survey For Mentors : FlyCROSS Mentor Mentee Matching Program We appreciate you taking the time and volunteering to be a mentor! Add dmelcross@gmail.com to your email address book or safe sender list, so that you can receive our emails. To be a participating me...

Hey #Drosophila folks ! #FlyCROSS is back and #Mentor surveys are open NOW ! If you're a faculty/postdoc/ equivalent in any scientific career & have #Drosophila research experience - we'd be delighted to have you as mentors to empower early career scientists in the #Dros community !

U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription t...

Very excited to share our new paper out now in
@MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells www.cell.com/molecular-ce...

Single-molecule multimodal timing of in vivo mRNA synthesis mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...

This sounds really really fun and useful.

This is SO useful for the community. Models for PD, SD, and more at the end of a click. Thanks Jax and all the people that made this possible!

The RNA with tentacle shape made it for me. This is great! (Congrats on the master!)

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...

I can’t be more proud of our team of amazing scientists. We had a great conference with science talks, career panels, and networking sessions!

We got RAs, students, postdocs, Pis, and scientists working in academia, industry, and policy.

I am inspired, proud, and energized (and also tired ;)

One of my favorite parts: We went deep into the literature and discuss some gems from the time of polytene chromosome microdissection. Seeing those microscopy images gives a different perspective into library prep trust me.

And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet

It’s so nice to see this work finally out! It developed so much since its early days. The idea of long lived RNA as experience decoys is huge. Still a lot of work to be done but this is a great first step forward. Happy to have been part of it!

Archaea go multicellular under pressure A microbe from the Dead Sea switches to a tissue-like form when compressed

@evapillai.bsky.social and I had fun writing a brief comment www.science.org/doi/10.1126/... (originally featuring an enlightening comparison to a soufflé au fromage that unfortunately disappeared from the final version per Science house style)

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!

www.biorxiv.org/content/10.1...

So so cool

Call for submissions: Metascience and AI postdoctoral fellowship | Alfred P. Sloan Foundation Our mission is to make the world a better place through the advancement of scientific knowledge.

Metascience and AI Postdoctoral Fellowships
Grants of up to $250,000 (USD) over up to two years will be awarded to social sciences and humanities postdoctoral researchers who study the implication of AI for Science.
Deadline: April 10, 2025
@sloanfoundation.bsky.social
🧪
sloan.org/programs/dig...

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

RNA xkcd.com/3056

A promotional image for 'rainbowR buddies' program with a vibrant rainbow striped background. The main text is displayed on a navy blue rectangle in the centre. The word 'rainbowR' appears at the top in multi-colored letters, followed by 'Buddies!' in yellow. Three bullet points explain: buddy pairs are randomly assigned, opportunity to forge connection, and chat about R or anything else! The bottom shows 'Sign-up by Sun Mar 2nd’ in green text, followed by website information 'rainbowr.org/buddies' in blue.

Sign-up for the next round of the rainbowR buddies scheme is open until Mar 2nd! Pairs will be introduced on Mar 3rd 🌈👯‍♂️

If you're LGBTQ+ and code in #RStats, and want an opportunity to connect with someone else in the community (through a random pairing), this is for you 😃

rainbowr.org/buddies

Senior Director - Scientific Officer Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biom...

HHMI Science Department is hiring! We are looking for an outstanding immunologist/ cancer biologist to join our senior leadership team. Remote work eligible, 24 weeks a year onsite, possibility of running a small lab with HHMI support

@hhmi.bsky.social

hhmi.wd1.myworkdayjobs.com/External/job...

Valérie Hilgers and co-workers @hilgerslab.bsky.social @mpi-ie.bsky.social and @zmbh.uni-heidelberg.de show that the conserved #neuronal #protein Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. #neuroscience

www.embopress.org/doi/full/10....

It's @scipyconf.bsky.social submission time again! This year I am running the Bioinf/Comp Bio/Neuroscience track, covering how Python is advancing science and problem-solving in those fields. Let me know if y'all have questions, and looking forward to the submissions!

So happy to see this out!!! Great work

😊🔬 Happy to share our preprint manuscript from my PhD! This study sheds light on stimuli specific activity-dependent gene expression and its changes during neuronal development in vitro. Looking forward to discussions and new perspectives!

Cool science with great people. Recommend!

Latin America and open access

Cell-type specific prediction of RNA stability from RNA-protein interactions RNA-binding proteins (RBPs) are important contributors to post-transcriptional regulatory processes. The combinatorial action of expressed RBPs and non-coding factors bound to the same transcript dete...

#paperalert!
In our new study, we ask the question: Can we predict RNA stability across conditions and protocols, based solely on experimental and/or computationally predicted RNA binding protein target sites?
Read the paper to find out !

www.biorxiv.org/content/10.1...

Inheritance: Leaving sticky notes for the children It is currently unknown to what degree parents’ life history can affect the next generation and how such information might be transmitted. A new study finds that nematodes transmit amyloid proteins to...

Big thanks to @odedrechavi.bsky.social and @ethanewe.bsky.social for the Dispatch in @currentbiology.bsky.social on our amyloid inheritance paper. www.cell.com/current-biol...

A #datascience for #socialjustice group I co-founded in Argentina is holding an amazing event about housing crisis this weekend in my home University. Help us spread the word!! And if you are in Buenos Aires, consider attending. It will be great!