Armin Lak

2 Lecturer (Assistant Prof) positions available @yorkpsychology.bsky.social! Come join our department!

#neuroskyence #cognition #psychscisky #neurojobs

jobs.york.ac.uk/vacancy/lect...

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently.

Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries.
www.biorxiv.org/content/10.1...

Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...

New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...

More of a coach than a fan!

thanks for the shout-out!

Very nice review!

Really awesome results. Congratulations all

Assistant or Associate Professor in Mammalian Neuroscience (110565-0625) at University of Warwick Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

Assistant Prof/Associate Prof position in Mammalian Neuroscience! 👩‍🔬👨‍🔬

My department is hiring! Closing on June 30th.

Please repost widely!

www.jobs.ac.uk/job/DNK944/a...

Thanks!

Oh thanks Tim!

Thanks

Thanks

Thanks

Thanks

& thanks to all authors: Samuel Liebana,Aeron Laffere, Chiara Toschi, Louisa Schilling, Jessica Moretti, Jacek Podlaski, Matthias Fritsche, Peter Zatka-Haas, Yulong Li, Rafal Bogacz, Andrew Saxe and our funders especially @wellcometrust.bsky.social

Bonus points i) We made the (big) data and codes publicly available (follow the links in the paper). ii) The paper is open access, thanks to our funders. So enjoy reading it in the train, in a beer garden or while cooking :)

We show that in learning to make decisions from naïve to expert, i)Individuals form diverse yet systematic learning trajectories. ii)Dopamine in select striatal regions acts as a teaching signal shaping the trajectories. iii)A deep RL model with heterogenous teaching signals accounts for the data.

Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...

Very interesting. Congratulations all

Because making theory needs good experiments and data. Such experiments are rare and hard because they need both thinking alot and doing alot…a rare combination

Two awesome papers on dopamine neuronal computations , congratulations to authors

Congratulations Matteo.

We’re hiring a postdoc with slice patch-clamp expertise to study head direction circuits and plasticity during spatial learning. Ideal for a neurophysiologist excited to combine ex vivo and in vivo approaches. Come join us in beautiful Cambridge! 🐭🧭🧠
📝 Apply by 9 June: www.jobs.cam.ac.uk/job/51282/

*** Come join us !! We are recruiting !! ***
How does the brain generate beliefs that go beyond direct experience? How do these mechanisms go awry in psychosis?

The Barron lab tinyurl.com/bdf4drjf @MRCBNDU @NDCNOxford are recruiting a new postdoc tinyurl.com/ut4vbwt4 to work in mouse models

photo of DPAG Sherrington Building in the sunshine

The Hulme Junior Research Fellowship offers early-career researchers a unique opportunity to advance their careers.
• Lead independent research projects
• Publish in high-impact journals
• Build multidisciplinary collaborations
Deadline: 12 noon, Monday 19 May
www.dpag.ox.ac.uk/work-with-us...

Motor learning refines thalamic influence on motor cortex - Nature Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...

Our paper is out in Nature.

By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.

Tour de force by Assaf in collab with Felix and Marcus. Congrats!

www.nature.com/articles/s41...

Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning Avoidance learning—learning to avoid bad outcomes—is an essential survival behavior. Dopamine signals are widely observed in response to aversive stim…

Pleased to share the final published version of @glopez.bsky.social's work in @currentbiology.bsky.social! www.sciencedirect.com/science/arti...

"Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning"

Congrats, Gaby!!!

Mice dynamically adapt to opponents in competitive multi-player games Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...

First preprint from our lab! An @jerlich.bsky.social collaboration

We developed novel frameworks to study multi-agent decisions in mice.

Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!

www.biorxiv.org/content/10.1...

A subcortical switchboard for perseverative, exploratory and disengaged states - Nature Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...

Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...