Targeted protein degradation community

1 week to go! Würzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped!
#wUeBI2025

TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!

@natsmb.nature.com

1/7

www.nature.com/articles/s41...

👏 Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs!

🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!

#TPD #PROTAC #LundSpringSymposium

🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:

🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab

Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com

#TPD #ProteinDegradation #Ubiquitin

🗺️ Interactive Map Update!

The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉

Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com

#ProteinDegradation

🗺️ Interactive Map Update!
The map was just updated with 3 more labs from Germany working on TPD:

🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social

Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com

#TPD #ProteinDegradation #Ubiquitin

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...

Great to see this out. A story that spanned continents, cities and budget codes…

www.nature.com/articles/s41...

Big thanks to all the teams involved!

@clausenlab.bsky.social @e3chembio.bsky.social

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP30, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a fram...

🔬 Lab Spotlight: Malte Gersch Lab at Max Planck & TU Dortmund @maltegersch.bsky.social

Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...

🧬 Exploring degraders? Check out PROTAC-DB — a free, searchable resource with data on 3,200+ PROTACs, warheads, linkers, E3 ligands, and more.

Includes binding data, degradation metrics, ternary structures, and WB images.

🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery

Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...

🗺️ TPD Research Map Update!
5 new labs just joined the global TPD map:

🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab

Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com

#TPD #ProteinDegradation #Ubiquitin

📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST):

🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.

Don’t miss it!

#TPD #Proteomics #Degraders

PVDF vs Nitrocellulose? How to Choose a Blot Membrane 🤔
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:

📌 Also includes practical tips for handling and troubleshooting.

#WesternBlot #LifeScienceTips

🔬 New from the Itay Koren lab:

💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.

doi.org/10.1038/s415...

👏 Congrats to all authors!

📍 Find the Koren lab + others on our map: tpd-community.com

#Ubiquitin #ProteinDegradation

Targeted Protein Degradation • From Small Molecules To Complex Organelles Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation.

🚨 Next week!
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!

Great science, great people, and great event for anyone into ubiquitin & TPD.

🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social

#TPD #Ubiquitin #ProteinDegradation

🔬 GRK2243 Symposium – Understanding Ubiquitylation

📅 June 2–4, 2025
📍 Würzburg, Germany

A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.

👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de

#TPD #Ubiquitin #wUeBI2025

🧬 Want to see who’s working on Targeted Protein Degradation or ubiquitin biology?

🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map

Discover labs and find collaborators.

#TPD #Ubiquitin #ProteinDegradation #ResearchMap

Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology.

👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com

#TPD #Ubiquitin #ProteinDegradation