Ian M Lahart

I Have Written You A Book On Forensic Metascience Use it to cause trouble

Friends, I have written you a book on forensic metascience.

It is free. You can have it. Happy St. Valentine's Day.

If you wish to give me a gift back, you can use it to cause trouble - the greatest gift of all.

open.substack.com/pub/jamescla...

How does ageing impact type I and type II myofibre properties in human muscle? Oscar Horwath, Marcus Moberg, Sebastian Edman, @willapro.bsky.social (The Swedish School of Sport and Health Sciences) and Andrew Philp (@centenaryinstitute.bsky.social) investigate.
📜https://buff.ly/40tFBJG

New book "Explanation in Biology" with Cambridge University Press is out & open access!

Covers (1) causal explanation & (2) non-causal/mathematical explanation in life sciences--bio, neuro, etc 🌿🧬🧠

Introduction to philosophical work on scientific explanation!

www.cambridge.org/core/element...

Chair Stop-Motion 🪑💨 Made with 444 pictures taken over 10 days

The (over)use of SMART goals for physical activity promotion: A narrative review and critique The SMART acronym (e.g., Specific, Measurable, Achievable, Realistic, Timebound) is a highly prominent strategy for setting physical activity goals. While it is intuitive, and its practical value h...

Just a reminder that SMART goals are not as empirically sound as you might think they are (at least for physical activity and exercise).

Full article: The (over)use of SMART goals for physical activity promotion: A narrative review and critique www.tandfonline.com/doi/full/10....

You’re being lied to about “ultra-processed” foods Coverage of the latest nutrition buzzword is overly broad, arbitrary, and misleading. The problem goes deeper.

The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...

Aw man, it started happening to me last year!?

Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s by Charles Piller Alzheimer’s research is a cesspool of faked results and moneygrubbing, according to this hard-hitting exposé. Science magazine j...

Charles Piller’s new book ‘Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s’ will come out in February. A fantastic read about those who discover science fraud and the lack of response by institutions and publishers.
www.publishersweekly.com/9781668031247

I met her on holiday!?!?

Mines a photo I staged in my living room to make it look like I’m speaking at a conference.

Drinking Guinness in *England* before it was cool! 😎

Title slide: Will your code run again? Tips for making code reproducible in R

If you missed my talk but still want to learn how to make your R code more reproducible, my slides are here 🙂:

daxkellie.quarto.pub/will-your-co...

All the links to packages and resources I mentioned are there, so hopefully this can be a nice reference, too!

#ESAus2024 #rstats #quartopub 🧪🌏

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice - PubMed The effects of aging on the satellite cell pool have primarily been studied in male mice, where the role of cell-intrinsic versus environmental changes on satellite cell function remains contentious. ...

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice | #MyoBlue

pubmed.ncbi.nlm.nih.gov/39641290/

From Stanley & Spence (2024): https://journals.sagepub.com/doi/full/10.1177/25152459241285885. "Myth 1: There is a 95% chance your true score is in your interval Some authors correctly understand that the Standard Error of Measurement can be used to construct a confidence interval for a specific individual’s true score. This type of interval is an SEM-Single-Test-Taker Interval. Unfortunately, however, sometimes these authors then go on to misinterpret the information provided by the confidence interval. For example, Kaplan and Saccuzzo (2013)"

Myth 1: Re-iterating this point over and over again improves psychologists' understanding of statistics in a practically relevant manner.

A figure from https://onlinelibrary.wiley.com/doi/10.1111/sms.14490 showing percentage error for simulated VO2 and VCO2 in 15 different metabolic carts across ranges of 1000-4000 mL/min. The error between carts ranges from -25 to +25%, with most devices clustered around ±10% "FIGURE 4 Relative percentage error for V̇O 2 (top) and V̇CO 2 (bottom), as a function of the simulated V̇O 2 and V̇CO 2 for each device. Errors are averaged over each step of the “Std” (i.e., RER = 1.00) and “CPX” (i.e., RER increases with increased V̇O 2 ) protocols. Because the simulated V̇CO 2 differed between the “Std” and “CPX” protocols, the average simulated value is depicted on the x-axis in the figure. MC, mixing chamber; RER, respiratory exchange ratio; V̇CO 2 , rate of carbon dioxide production; V̇O 2 , rate of oxygen uptake."

Bas van Hooren et al recently published a comprehensive review of metabolic equipment

With rigorous calibration & operation, and taking out all possible biological variation with *simulated* gas exchange, the error between carts is still ±10+%

onlinelibrary.wiley.com/doi/10.1111/...

Title slide: Acting as if our research might matter - Analyzing data Image: A meteor about to strike the earth.

Clinical Researchers:

I am here to warn you about a meteor hurling towards us.

That meteor represents increasing scrutiny of clinical research; and in particular how we approach data collection, analysis, interpretation and reporting.

Prepare now, or face the consequences.

1/

You keep doing you, we’ll just have to catch up! 😅

James, you know I’m a huge fan of yours! So I say this with great respect! Speak clearly in plain language!

Yes, I’m religious. I believe in the holy trinity.

@katebolam.bsky.social welcome Kate!!!!

And I broke Joao Pedro.

@jesperfchristensen.bsky.social welcome to Blue Sky!!!!

So look. I've given about 20 talks where I highlight clinical research waste, and I now always ask the audience if they recognize that figure below. The answer is *always* the same - overwhelmingly No. If *you* recognize it, because you are here and informed, you must help spread the word. Please.

Muscle regeneration and muscle stem cells in metabolic disease Skeletal muscle has a high regenerative capacity due to its resident adult muscle stem cells (MuSCs), which can repair damaged tissue by forming myofi…

Comprehensive and timely new review on muscle regeneration impairment by diabetes www.sciencedirect.com/science/arti... of note: interesting angle on the synergy between intrinsic and extrinsic detriments of diabetes on muscle stem cells @myoblue.bsky.social

Played in Dublin the other week didn’t they?

✨ PREPRINT 📖🤩

"Study Preregistration: A How-To Guide"

Written for students, this guide outlines the 'what, why, and how' of preregistration, perceived barriers and their solutions, and 10 top tips to adopting and/or critically evaluating this open research practice.

osf.io/preprints/ps...

Episode 57: Collider bias Listen now | Does smoking prevent COVID? Is being obese actually healthy? Or is something funny going on?

Some said it couldn’t be done. That it was impossible; ridiculous; absurd. But @tomchivers.bsky.social and I have done it: recorded a whole podcast episode about collider bias. www.thestudiesshowpod.com/p/episode-57...

Ultra-Runners: Help researchers understand more about NSAID use in racing and perhaps find a viable (safer) alternative. #running #ultramarathon

He’s finally out?

Just enough Indie and Rock bands to get me there! 😂