Mark Gresnigt

AI-generated drawing of a woman looking through a microscope with DNA and fungi drawn in the background. The text contains the same content as the bsky post.

My group at is hiring a PhD student to explore how fungal pathogens that live in the environment will adapt their genomes, acquire new phenotypes, and perhaps even increased infectivity as a result of climate change. Please share!

More info and applications at @ jobs.uni-jena.de/vrbup

A comparison of two photos of Candida albicans shows that a denser biofilm is formed in the presence of human albumin (right) than in its absence (left). In the photos, the yeast cells were colored in a golden hue.

💡 New infection strategy in #Candida albicans discovered: human #albumin reprograms its metabolism, turning harmless strains pathogenic – without the need of hyphae or toxins. #LeibnizHKI
🗞️ lmy.de/mthFi
🧪 rdcu.be/exl7d

@markgresnigt.bsky.social @aps-hki.bsky.social
@dfg.de @microverse.bsky.social

Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway - Nature Communications Candida albicans normally relies on specific pathogenicity mechanisms to cause tissue damage. This study reveals that when sensing host albumin, C. albicans, even avirulent strains, can trigger an alt...

We are exited to share our story just out in @natcomms.nature.com on how the yeast Candida albicans can exploit human albumin to engage an alternative pathogenicity pathway, not relying on previously uncovered virulence factors.
www.nature.com/articles/s41...

Our newest review is published in @femsjournals.bsky.social! Marisa Valentine discusses the host-pathogen-microbiome interactions during #vaginal #Candida infections.🍄🧫🦠
Big thank you to Duncan Wilson and @markgresnigt.bsky.social for contributing!

👉 academic.oup.com/femsre/advan...

What an incredible joint meeting „FungiNet – Pathogenic fungiand their human host“ & „Invasive Mycoses in Haematological Malignancies – IMIHM XV in Würzburg!
🌟 The discussions were enlightening, and the talks were truly inspiring.
🙌 A big thank you to everyone involved!

The meeting ended with an exciting panel discussion on possible future directions after 12 glorious years of the @dfg.de funded @trr124-funginet.bsky.social consortium. With @estukenbrock.bsky.social, Oliver Kurzai, Axel Brakhage and others.

Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books Abstract. Textbooks remain a primary source of reference and education for many health care professionals and students. This study assessed the mycology co

Cracks in the Curriculum: The Hidden Deficiencies in Fungal Disease Coverage in Medical Books

Isabela Rost / Alessandro Pasqualotto and colleagues

academic.oup.com/ofid/article...

Fascinating evening🌇keynote given by David @sancholab.bsky.social on how the gut microbiome trains the immune system inside the bone marrow🦴 and how its metabolites impact atherosclerosis 👏🏻

And keynote speaker of day 2 Karsten Hiller of @tubraunschweig.bsky.social is giving us a deep dive into immuno metabolism in macrophages: #itaconate rules ✌🏻🤓 #Rothenfels2025

We are incredibly proud of Kar On Cheng for winning the best presentation award at the 28th Symposium: "Infection and Immune Defense". She presented her doctorate project on IL-36 and its role in inflammation during RVVC. Congratulations Kar On!!!

My group @aps-hki.bsky.social is looking for a new postdoc in immunology of fungal infections focusing on vulvovaginal candidiasis. Please contact me for further details in case of interest.

#GRCIFI 2025

Pathogenic microorganisms employ adaptive strategies to escape host defense. Hitzler et al. explore how bacterial and fungal pathogens escape the host immune system. https://buff.ly/4ajQ9On
#FEMSMicrobiolRev
@markgresnigt.bsky.social

Lactic acid in the vaginal milieu modulates the Candida-host interaction Vulvovaginal candidiasis (VVC) is one of the most common infections caused by Candida albicans. VVC is characterized by an inadequate hyperinflammatory response and clinical symptoms associated wit...

Proud to share our latest article with the group of Mihai Netea showing that lactic acid in the vaginal milieu modulates the Candida-host interactions that underlie the immune responses associated with vulvovaginal candidiasis www.tandfonline.com/doi/full/10....

Join our team at the Leibniz-HKI as Technical Assistant - application deadline closing soon! 📣

Microbial adaptive pathogenicity strategies to the host inflammatory environment Abstract. Pathogenic microorganisms can infect a variety of niches in the human body. During infection, microbes can only persist if they adapt adequately

We are excited to share that in the last few days of 2024 our review on how bacterial and fungal pathogens🦠🍄🧫 bind and/or sense immune mediators to evade and escape the immune system has been published in @femsjournals.bsky.social #FEMSMicrobiologyReviews.
academic.oup.com/femsre/advan...

In the past years, I've found using comic-inspired color palettes super helpful when creating figures for my papers. Just came across this one and I’m definitely using it next!

💡Any comic recommendations with cool color palettes?🌈
#AcademicSky @academic-chatter.bsky.social @thephdplace.bsky.social

Shocking moment today: Got told by the pediatrician today that I should open a bottle of prosecco to celebrate that our son was now through his full first set of vaccinations. Apparently is not that common anymore that people let their children be fully vaccinated 🤯

In our @dfgpublic.bsky.social funded research grouop we use this system in our lab to see how Candida albicans adapts to the different host stimuli we expose it to.

For our first post, we would like to share that we are enjoying how our live-cell imaging system (Funded by the state of Thuringia and co-funded by the EU) can use a neuron tool to quantify fungal hyphal growth.

See the paper by Wurster et al. who established this journals.asm.org/doi/epub/10....

This week my group started to work in our new labspace at the Leibniz-HKI after a lot of restructuring and reorganization. Happy we can finally get some experiments done in the new rooms.

My Strava would have really poor times…. 😅 I write slow

Hello 👋🏼 all. Happy to join here for the science chats