..now with enhanced visibility 👀

6/6
These findings challenge the idea of fine-scale spatial organization in CA1 and support a distributed coding architecture 💡🧠

Thanks to the team:
@hannaeneqvist.bsky.social
Nienke L. De Jong
@emilierskytoen.bsky.social
@weijianzong.bsky.social
@m-bmoser.bsky.social
@edvardmoser.bsky.social

5/6
Place fields were spatially distributed rather than anatomically clustered 🧩
Not even at the nearest-neighbor scale was there evidence for topographical organization

4/6
But that’s not what we found.
There was no evidence that neighboring CA1 neurons share place field locations 🏘️❌.

3/6
We examined place field locations 🎯 during open-field remapping
If small-scale topography exists, anatomically nearby CA1 neurons should encode nearby locations in space.

2/6
To test this, we used #Mini2P 🔬 to image thousands of CA1 neurons simultaneously in freely moving mice 🐭
This allowed us to combine high anatomical precision with natural behavior.

1/6
Do neighboring #PlaceCells in #Hippocampus CA1 map neighboring locations in space? 🧠🗺️
Is there micro-scale spatial topography in the hippocampus?
See our latest paper from @kavlintnu now out in @pnas.org www.pnas.org/doi/10.1073/...

Place cells in CA1 lack topographical organization of firing locations | PNAS Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

A half-century old question may have its final answer. Using high-resolution #Mini2P microscopes, we find no evidence of local topography in #PlaceCells. Place fields of neighbouring cells are no more similar than those of randomly selected cells. 🧠🗺️ Out now in @pnas.org www.pnas.org/doi/10.1073/...