Paul A. Welling, MD

www.physiology.org/professional...

The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals Most scenarios that seek to predict the responses of terrestrial mammals to climate change focus on the direct thermal effects of higher ambient temperatures. Measurements from free-living mammals rev...

The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals - www.annualreviews.org/content/jour...

Are you a physician-scientist in training? Are you looking to connect with other trainees? We are proud to help sponsor two upcoming APSA Regional meetings: the South and Mid-Atlantic Regional meetings. 🧪

Find your meeting: https://www.physicianscientists.org/page/RegionalList

Early-Stage Investigator (ESIs) Resource Showcase Travel Awards to support ESI participation and attendance at the inaugural George M. O’Brien Kidney Resource Alliance (OKRA) Resource Showcase. To apply, complete the online application (okra.awardsplatform.com) by 022326.

The response to kidney injury is epigenetically regulated through the activation of bivalent genes | American Journal of Physiology-Renal Physiology | American Physiological Society Epigenetic regulation through histone modifications plays a crucial role in driving cellular state transitions. Regulating gene transcription through bivalency, the co-occurrence of activating histone...

journals.physiology.org/doi/full/10....

YouTube video by Bruce Springsteen Bruce Springsteen - Streets Of Minneapolis (Official Audio)

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

Have you checked out the latest #KPMP publication in @kidneymed.bsky.social? If not, what are you waiting for?

Dive in today!

www.kidneymedicinejournal.org/article/S259...

apsoc.informz.net/informzdatas...

I spent the morning at the San Antonio immigration court. It’s out of control.

Crawling with ICE - arresting legal immigrants showing up for court appearances.

I asked one officer who they are prioritizing. His answer: everyone.

I need to share with you what I saw.

Review article by Yuuta Imoto and Shigeki Watanabe
"Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis"
🖱️https://ow.ly/evL150XY7S2
#UltrafastEndocytosis

The NIH has lost its scientific integrity. So we left “We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

Powerful piece in STAT this morning from some NIH staff members who have resigned

www.statnews.com/2026/01/10/n...

1/3

Here's a summary of all the data that supports adding more red meat to your diet

Remarkable: a treatment-induced increase in plasma potassium levels led to a significantly lower risk of appropriate ICD therapy, unplanned hospitalization for arrhythmia or heart failure, or death from any cause than standard care.

Speaker addressing a large audience at the American Physiology Summit in a spacious, well-lit conference hall.

From unraveling chronic pain to exploring the body's sensing system, #APS2026 game changers feature some of the biggest topics in the life sciences. Don't miss top scientists from around the world as they discuss these vital issues. More: https://ow.ly/Clpz50XSBG9 #WeArePhysiology 🧪

Did you miss the PKD RRC Monthly Scientific Roundtable for January 2026? No worries, the outstanding presentation by Vishal D. Patel, M.D., UTSWMC, is now available at
www.pkd-rrc.org/pkd-rrc-mont... #endPKD #PolycysticKidneyDisease

🌟 Call for Applications for Editor-in-Chief of AJP-Heart and Circ 🌟

We're looking for an engaging and dynamic Editor who will be actively involved in shaping the strategic direction of the journal. To submit your application ➡️ https://ow.ly/AkAp50XC57C

American Physiological Society

🌟 Call for Applications for Editor-in-Chief of Physiological Reviews🌟

We're looking for an engaging & dynamic Editor to actively commission Reviews from high impact authors across all areas of #physiology. https://ow.ly/2oSy50XC4Nb

American Physiological Society

Congrats to Diogo Manoel, et. al, for the #APSselect paper "Functional characterization and cAMP-mediated rescue of a novel truncating AVPR2 mutation causing nephrogenic diabetes insipidus" in @AJPEndoMetab
@saraivalmr @saraivalab @sidramedicine

https://ow.ly/c38u50XFNEc

This #ASNJASN research explored how two transcription factors, Dmrt2 and Hmx2, influence the differentiation of intercalated cells in the kidney, which are crucial for acid-base balance. Read more: kidney.pub/JASN0885 #BasicScience

Young child with brown hair looking sideways under text about the importance of physiology in science and life.

Physiology provides the foundation every medical advancement depends on. Our Physiology: The Science Life Depends On campaign elevates awareness of physiology’s crucial role in science and advocates for sustained research funding. Learn more at fightforphysiology.org #FightForPhysiology🧪

AlphaFold is five years old — these charts show how it revolutionized science Nature - Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.

Five years ago, researchers at Google DeepMind unveiled AlphaFold2

go.nature.com/3M1Tvxx

Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | Amer... We examine the role of mTORc2 in mediating overnight-high-K+-(HK)-intake-induced stimulation of renal-outer-medullary-K+-channels (ROMK) in late distal-convoluted-tubule DCT2)/early connecting-tubule ...

Mechanistic target of rapamycin complex-2 (mTORc2) mediates the effect of over-night high K+ on Kir4.1/Kir4.1 in the DCT and ENaC/ROMK in ASDN. | American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...

The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK | American Journal of Physiology-Renal Physiology | American Physiological Society Renal outer medullary K+ (ROMK) channels are essential for urinary potassium secretion, and their endocytosis prevents excessive K+ loss during dietary deficiency. The clathrin adaptor autosomal reces...

The clathrin adaptor ARH not only targets LDL for endocytosis but also mediates the internalization of the key kidney potassium excretory channels, ROMK and BK. Here, we show why people who lack functional ARH do not waste potassium in their urine. journals.physiology.org/doi/full/10....

Portrait of an elderly person outdoors with text promoting progress in physiology science. The text reads The Science Life Depends On. Let's drive physiology forward.

ICYMI, last week we launched "Physiology: The Science Life Depends On," a campaign to champion the discipline and protect the science behind every breakthrough. Our goal: to reintroduce physiology to the world. Learn more and join the #FightForPhysiology: fightforphysiology.org 🧪

A young child with brown hair looks off to the side with a thoughtful expression against a soft gray background. Above her, bold text reads: “The science life depends on. Let’s drive physiology forward.” The word “life” is written in colorful script, and “physiology” is underlined in pink.

Today, APS is launching Physiology: The Science Life Depends On, a campaign to champion #physiology and protect the science behind every breakthrough. It's time to reintroduce physiology to the world, together. Join the #FightForPhysiology at fightforphysiology.org 🧪

My condolences.

Figure 1 Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.

Is it not really TGF - and something else in the tubules?

Fascinating Biomarker study in @ajkd.bsky.social from the EMPA-KIDNEY group

www.ajkd.org/article/S027...

cc @pranavgarimella.bsky.social

#NephSky #RevengeOfTheTubules

This #ASNCJASN original research identified ten plasma proteins associated with dietary potassium and CKD risk in a US adult population, highlighting mechanisms involving iron deposition, mitochondrial function, inflammation, and fibrosis. Read more: kidney.pub/CJASN0864

@pawellingmd.bsky.social

A randomized controlled trial in #ASNJASN finds that adjuvant thiazide improved diuretic response more than loop dose increased in patients with acute heart failure and diuretic resistance. Read more: kidney.pub/JASN0887

@pawellingmd.bsky.social

A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ