Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery ...

A reminder of the importance of model organisms in scientific breakthroughs www.nature.com/articles/s41...

Tuberculosis Defenses

Catching up on some blog topics: how do you get things past the weird defenses of tuberculosis bacteria, anyway?

We have people in power making broad claims around certain drugs and autism that have been continuously disproven.

A generative deep learning approach to de novo antibiotic design A generative AI platform is developed for de novo antibiotic design, yielding lead compounds with selective antibacterial activity, distinct mechanisms of action, and in vivo efficacy against multidru...

www.cell.com/cell/abstrac...

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...

We are extremely happy to share our new work on glutamine addiction in cancer cells. www.biorxiv.org/content/10.1...
Looking forward to your feedbacks

La scelta - I Partigiani raccontano | RaiPlay Sound Nel 2020, in occasione del 75° anniversario della Liberazione dall'oppressione nazi-fascista, Gad Lerner raccoglie le storie di tutti i partigiani e le partigiane viventi, ultime testimonianze dirette...

Buon 25 aprile . Festa della liberazione

www.raiplaysound.it/programmi/la...

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

www.nature.com/articles/s41...

No matter what you think of the Israel/Palestine situation, and no matter what you think of the Columbia Univ. protests:

If ICE can grab a permanent resident, suddenly revoke their Green Card (!) and whisk them away to a distant prison incommunicado, no one’s liberties are really safe.

Same Drug, New Actions: Metabolomics Reveals Hidden Drug Effects Studying drug-induced metabolic changes with high-throughput systems shed light on drug modes of action, providing an efficient drug discovery platform.

Our work is now featured in The Scientist! Thanks Sneha Khedkar for such a clear and exciting presentation of our research.

www.the-scientist.com/same-drug-ne...

The Thiazide Target, At Last

For decades people have searched for the vascular target of the widely used thiazide blood pressure drugs. Looks like it’s been found!

Sad to know about the passing of Béla Novák. This review from Tyson, Chen and Novak was such a revelation for me as an introduction to control theory in biological systems. A classic that will remain relevant for many years to come. www.sciencedirect.com/science/arti...

Proteomics LC-MS Specialist (100%)
Proteomics Core Facility, Biozentrum
www.biozentrum.unibas.ch/open-positio...

@biozentrum.unibas.ch @unibas.ch #Biozentrum #Basel #research #science #joboffer #proteomics #LC-MS #Specialist

We are seeking for a talented semester or master student for a computational project on antimicrobial effects of drugs. Check it out!

www.zampierilab.org/join-us/

In a collaborative effort, Petya Apostolova and colleagues found a way to combat immune-related adverse events during immune checkpoint inhibitor treatment, here shown in action. (Image: Adobe Stock, KI)

Exciting news from the Apostolova lab
@biomedizin.unibas.ch! A study by Petya Apostolova & Robert Zeiser shows extracorporeal photopheresis is effective in treating immune-related adverse events from checkpoint inhibitors. www.cell.com/cancer-cell/...

#CancerResearch #Immunotherapy #ECP #ICI #irAE

Revised and Extended: What's Happening Inside the NIH and NSF

www.science.org/content/blog...

📢📜 Celebrating some fantastic recent papers from our people!

Rentsch Lab @nccr-antiresist.bsky.social 👉 onlinelibrary.wiley.com/doi/10.1002/...

Bumann Lab 👉 www.nature.com/articles/s41...

Zampieri Lab 👉 nature.com/articles/s41...

@knutdrescher.bsky.social Lab 👉 www.nature.com/articles/s41...

Mapping metabolite disturbances by drugs High-throughput metabolomic profiling gives insight into unpredictable drug effects

Our work was featured in chemistryworld. Fantastic pitch of our research by @AntonyJKing

www.chemistryworld.com/news/mapping...

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)

Thanks!

Really nice work!! www.cell.com/action/showP...

Fantastic work by @zampierilab.bsky.social‬ (formerly at IMSB) on studying drug mode of action using large scale metabolic profiling.

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!

Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...