Aleksandra Gruevska

Membrane Biology: Nothing can replace polyunsaturated lipids

Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
buff.ly/qcLJNUN

Enjoying #metabolomics2025 in Prague! Just presented some of our work on #massspec imaging of #liver fibrosis! @gruevska.bsky.social

See you this weekend!!!

Excited to present our work at #EASLCongress 2025 (THU-036-YI). See you tomorrow at 1pm on the Track Hub 2 - Basic science to check how we use #massspecimaging and IMC for metabolic profiling of #liver fibrosis. Special thanks to our collaborators and funders @zoehall-icl.bsky.social

@imperialmdr.bsky.social @imperialmed.bsky.social

Using #massspecimaging we show #lipid #metabolism is dysregulated spatially in #liverfibrosis. By integrating MSI and IMC, we linked #sphingolipids with non-parenchymal cells. Targeting sphingolipid metabolic pathway in HSCs and hPCLSs showed anti-fibrotic effect.

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding the specific mechanisms of lipotoxicity, dysregulate...

Very happy and proud to see our work published in Metabolism!

www.metabolismjournal.com/article/S002...

We thank all our collaborators and especially all the patients who contributed to the study.

Thank you @zoehall-icl.bsky.social for all the support since day one!

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding th…

Excited to share our latest study in Metabolism, exploring how dysregulated #sphingolipid #metabolism contributes to #liver #fibrosis using #spatial #lipidomics! A huge thank you to @gruevska.bsky.social and all the collaborators who made this possible!

www.metabolismjournal.com/article/S002...

Thanks Hannah 🤗

Sarah explains the stages of #FattyLiverDisease.

It's possible to slow or even reverse damage to the liver - the main treatment is eating a healthy diet, being more physically active & (if needed) losing weight.

More about fatty liver disease: britishlivertrust.org.uk/information-...

#LiverSky

Need a laugh?

Here are this week's best academia and science funnies I found.

#AcademicSky 🧪

Pleased to see our review (w/ Cathrin Gudd & Lucia Possamai) on immune-mediated liver injury from checkpoint inhibitors published in @natrevgastrohep.bsky.social 's latest issue | @imperialmdr.bsky.social | #cancer #immunotherapy #liver #inflammation

Together with friend and collaborator
@joharrr.bsky.social, we highlight spatial metabolomics as a new Tool to understand cell biology!

t.co/mZ6pBiDRUQ

Home Imperial College London is a world-leading university for science, technology, engineering, medicine and business (STEMB). Across our London campuses, and throughout our international network, we use ...

Calling computational #metabolomics people out there! Are you interested in working with #EU colleagues to analyse and model metabolomic data? We are looking for an enthusiastic and knowledgeable individual to join the #BiACEM
project: www.imperial.ac.uk/jobs/search-...

Some of my favorite mass spec imaging data of the year 😍 Fibrotic #liver and shining #lipids.
#liversky #MassSpec #MALDI #metabolomics

a stack of gift boxes with the words happy boxing day below ALT: a stack of gift boxes with the words happy boxing day below

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day

Starter pack 1: go.bsky.app/VavECSX

Starter pack 2: go.bsky.app/CH1MctZ

Inter-organ communication is a critical machinery to regulate metabolism and aging Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.

www.cell.com/trends/endoc...

@cp-trendsendomet.bsky.social

A lipid made by tumour cells reprograms immune cells Insights into how cancer cells become unresponsive to therapy.

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz