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@dairegannon.bsky.social

Postdoctoral researcher at WEHI

35 Followers  |  41 Following  |  3 Posts  |  Joined: 11.05.2025  |  1.5138

Latest posts by dairegannon.bsky.social on Bluesky

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Congratulations to the winners of the 2025 AEpiA Emma Whitelaw Publication Award!

๐Ÿงฌ 1st place: @shellainasci.bsky.social
๐Ÿงฌ 2nd place: @victoriasugrue.bsky.social
๐Ÿงฌ 3rd place: @dairegannon.bsky.social

This award recognises outstanding publications by ECRs in the field of epigenetics.

20.10.2025 06:16 โ€” ๐Ÿ‘ 13    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Absolutely delighted to share our preprint, using functional genomics to uncover a novel dependency in lymphoma that can overcome resistance to targeted therapy. Grateful to co-first author @jamesnolan.bsky.social and co-senior authors @conwayer1.bsky.social and @adrianbracken.bsky.social see๐Ÿ‘‡

17.10.2025 14:07 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. ...

๐Ÿงต1/Exciting news in cancer epigenetics! Our latest research, "AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma", is now available on www.biorxiv.org/content/10.1.... Here's a thread summarizing our findings!๐Ÿ‘‡
#CancerResearch #Epigenetics #Chromatin #Lymphoma

17.10.2025 07:10 โ€” ๐Ÿ‘ 23    ๐Ÿ” 10    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2

Thanks Jongmin!

07.06.2025 02:44 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover a key role for CBX4 and its central region in promoting the growth of diffuse midline glioma cells bearing the ...

Great to see @jongminkmg.bsky.socialโ€™s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...

06.06.2025 08:37 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4โ€™s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.

Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:

21.05.2025 15:19 โ€” ๐Ÿ‘ 6    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Our work identifying CBX4 as a potential therapeutic target for diffuse midline glioma has just been published in Molecular Cell! Check out co-first author @eimearlagan.bsky.socialโ€™s overview below.

21.05.2025 21:25 โ€” ๐Ÿ‘ 7    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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