Paul Young

Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism Nature Communications - Hyperactivation of the cystic fibrosis transmembrane conductance regulator (CFTR) is central to the pathogenesis of secretory diarrheas and autosomal dominant polycystic...

Happy to have this work out! Using cryo-EM and electrophysiology, we clarify the mechanism of a small molecule inhibitor of CFTR that could have some important clinical applications.
rdcu.be/eyVyq

02.08.2025 16:31 — 👍 9    🔁 3    💬 0    📌 0

I have noticed that many cool people are starting labs at Ohio State right now. I've decided to follow their lead.

Soon, my lab will be moving to Ohio State as well.

You can learn more about our recent and upcoming work here: www.cogdevlab.org

25.06.2025 13:44 — 👍 56    🔁 7    💬 3    📌 0

Incredibly excited and grateful to share that I’ll be starting a lab at The Ohio State University this(!) fall! My lab will study human learning and memory, with related interests in sleep, stress, and time perception. More info soon, but do get in touch if you’re interested in joining!

24.06.2025 15:03 — 👍 142    🔁 30    💬 7    📌 4

Hippocampal encoding of memories in human infants Humans lack memories for specific events from the first few years of life. We investigated the mechanistic basis of this infantile amnesia by scanning the brains of awake infants with functional magne...

Why do we not remember being a baby? One idea is that the hippocampus, which is essential for episodic memory in adults, is too immature to form individual memories in infancy. We tested this using awake infant fMRI, new in @science.org #ScienceResearch www.science.org/doi/10.1126/...

20.03.2025 18:36 — 👍 482    🔁 166    💬 23    📌 22

Protest sign with black text listing a subset of words that were flagged for further scrutiny by federal agencies (including “bias” “increase diversity” “disability” “racism” “trauma” “victim” and “women”). In large red letters over top, the words “These words kill fascists” is written, an homage to Woody Guthrie.

We will keep fighting and standing up for science.

11.03.2025 15:17 — 👍 254    🔁 44    💬 0    📌 0

I am grateful that right now I am part of a very supportive community — though at the same time, it is painful to know that I’m not alone.

11.03.2025 15:17 — 👍 115    🔁 4    💬 3    📌 0

Last year, I was overjoyed to receive an NIH NRSA fellowship to study toddler brains and caregiving effects on memory at Columbia. Last night, my grant was terminated.

11.03.2025 15:17 — 👍 1021    🔁 378    💬 85    📌 18