Denis Chrétien

Attendees of the recent bacteriorhopsin symposium, photographed from above.

Balsawood model of bacteriorhodopsin

Black and white photograph of Nigel Unwin and Richard Henderson sitting outside the LMB, 1991

Symposium attendees applauding in the LMB's Max Perutz Lecture Theatre.

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.

Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...

#LMBNews 🧪🔬

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

To tilt or not to tilt? Strategies for in situ cryo-EM data collection Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

Our paper on Lymphostatin is now out (rdcu.be/etk2v). It shows #cryoEM structures of this huge virulence factor revealing amazing domain reorganisations.
Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de 🧪❄️

🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...

it never gets old...... #microtubule dynamics - the fireworks of EB comets #microscopy

Beautiful 😍

Dual-axis cryo-ET on cryo-FIB milled lamella 🙂 www.researchsquare.com/article/rs-6...
#CryoEM

ERC grantee wins the Shaw Prize in Life Science and Medicine 2025 Shaw Prize honours ERC-funded research in molecular imaging

🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET!

Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025

Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM, @leaswistak.bsky.social and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale.

@enningalab.bsky.social @jytinevez.bsky.social @nanoimaging.bsky.social

#CryoEM

Coupes tissulaires d'un tissus visualisé en 3D par microscopie électronique ? Mais quel tissus ... Au niveau du coeur ? (aorte en haut à gauche ?).

N'est-ce pas deux galaxies en interaction ?

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

It's #MicroscopyMonday, so let's take a peek into the 🔬
This movie was taken by Shinya Inuoe, who built the polarizing microscope that allowed scientists to see mitotic spindle fibers live for the first time.

Dr. Inuoe premiered his research at MBL.

Choose Europe (France) for Science #ESR

(credit : Jérôme Sié)

I'm surprised that Didier Raoult is not in the author list 😂

Très simple d'utilisation et abordable financièrement, je recommande 😍

Télescope Seestar S50 ZWO All-in-One | Loisirs Plaisirs Découvrez le télescope Seestar S50 ZWO all-in-one. Un réflecteur automatique parfait pour les astronomes et les astrophotographes débutants !

Seestar S50, idéal pour la lune, le soleil, les galaxies et nébuleuses, pas pour les planètes (mars, Jupiter etc...).
www.loisirsplaisirs.com/telescope-zw...

Galaxie du Tourbillon (M51) prise avec le Seestar S50 (4 min d'exposition).

Et là la galaxie du Tourbillon (M51) prise également hier soir 🙂

Croissant de lune du 30 avril 2025 pris avec le Seestar S50

La même hier soir avec mon petit télescope ;-)

The ARM 200 and now the TIRF, the origins of microtubule dynamic instability will be solved soon 🤩

WOSM-TIRF up running! Awesome #Tirf imaging of microtubules and EB comets in #Xenopus egg extract. The WOSM-TIRF is the big brother of the eduWOSM (doi.org/10.7554/eLife.104046.1). So grateful to @irobcross.bsky.social & Nick Carter for this collaboration & @agencerecherche.bsky.social for funding.

I think that with Reynald's team, there will be plenty of ribosomes imaged by this machine! (and also some microtubules 🙂).

#JEOL CRYO ARM™ 200 #CryoEM installed at the Institute Genetics & Development of Rennes.
First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography.
We wish IGDR success with their future research projects.

First images coming soon 🤩

So beautiful 😍

Rediscover the fundamentals of cryo-EM with NIS CSO, Giovanna Scapin! Join us for three engaging sessions covering Sample Preparation & Imaging, Data Process... Cryo-EM: Back to Basics - Chapter 1

The third and final chapter of our webinar series “Cryo-EM: Back to Basics” is on demand. Hear from Giovanna about challenges in #cryoEM, how to overcome them.

Catch all three chapters:

Chapter 1: youtu.be/e8GyDe4_BAQ
Chapter 2: youtu.be/2dBnPVkaoFs
Chapter 3: youtu.be/kUGNSTGc8II