Giulia Pasquesi

New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!

All the credit for this discovery goes to postdoc @giuliapasquesi.bsky.social , who first noticed the isoform in her 2020 Lockdown Sideproject (tm). Her perseverance, creativity, and talent made this study possible and it was an honor to be a part of it. Watch out for her--she's on the job market! 😉

A story of transposons, innate immunity, and how human (and primates) possess an endogenous system to tune interferon response through the relative expression level of a signaling receptor and its alternatively spliced decoy.

It wouldn't be my profile otherwise 😍

Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells - Mobile DNA Background Bats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate immunity and inflammation. Recent studies have revealed...

First work out of my Postdoc (and the pandemic) in 2022. We looked at the contribution of TEs to bat immune responses. Surprisingly, no strong evidence in support of genome-wide epigenetic activation of TEs in response to IFN (contrary to other mammals)!
link.springer.com/article/10.1...

Vertebrate Lineages Exhibit Diverse Patterns of Transposable Element Regulation and Expression across Tissues Abstract. Transposable elements (TEs) comprise a major fraction of vertebrate genomes, yet little is known about their expression and regulation across tis

Following up on Nat. Commun. 2018, we analyzed the relationship between TE transcription and expression levels of genes involved in TE silencing in somatic and germline tissues across vertebrates.
doi.org/10.1093/gbe/...

One of my favorite works. And it had been an honor to be a part of it
genome.cshlp.org/content/29/4...

Squamate reptiles challenge paradigms of genomic repeat element evolution set by birds and mammals - Nature Communications Large-scale patterns of genomic repeat element evolution have been studied mainly in birds and mammals. Here, the authors analyze the genomes of over 60 squamate reptiles and show high variation in re...

In the awe of next week big reveal, a little bit of my past.
My very first First-author paper (Nat Commun 2018), as a grad student in Todd Castoe lab. We showed unique characteristics of the conflict between genome size and TE activity in squamates compared to other amniotes.
doi.org/10.1038/s414...