Natalia Nombera Aznaran

1/10 Last #NephJC we discussed Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN #TenPostNephJC
Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit.
www.nejm.org/doi/full/10....

Excellent job @glomerican.bsky.social 🤩🤩

Maybe as an early option for biopsy proven recurrent with proteinuria, declining egfr and active lesions. Not as first line though for low grade proteinuria. #NephJC

a man says " stay tuned " in a video ALT: a man says " stay tuned " in a video

#NephJC

an elderly woman is crying and says `` still waiting ... it 's been 84 years ... `` ALT: an elderly woman is crying and says `` still waiting ... it 's been 84 years ... ``

#NephJC

Let’s keep in mind that VALIANT had less than 10% history of transplant #NephJC

We need to see longer follow up recurrence, progression to ESKD. Maybe sequential or switching for partial responders or intolerant but still food for thought #NephJC

Yes and because it was hierarchical design they couldn’t get conclusion for the other outcomes - staining #NephJC

Even if they started with lower UPCR in the placebo, the shift is good in intervention vs placebo! #NephJC

Change in activity score didn’t differ though 🧐 #NephJC

Good point!!

a man in a white shirt and tie is sitting at a desk with his mouth open . ALT: a man in a white shirt and tie is sitting at a desk with his mouth open .

Me too I was surprised too #NephJC

Pts with intervention had lower egfr and higher UPCR 🧐🧐 #NephJC

Not all completed the open label period 🧐 #NephJC

Not in Peru at least #NephJC

But not for the adolescents though 🧐 #NephJC

🎨Beautiful visual abstract by Dr Akshaya Akshaya Jayachandran #NephJC

A rockstar of the VAs!!

Hi Natalia Nombera here 🙌🏼🙌🏼 No COI Just a Stranger Things fan! #NephJC

7. Personal level. Beyond his talent and expertise, I met an extraordinary man. Humble, altruistic, wise, friendly, and with a great sense of humor. I brought him a vacuolar cast tie as a present and he wore it proudly right away 🤩

6. Prof. Fogazzi. Definitely a big highlight for me was to meet for the 1st time Dr Giovanni Fogazzi, an icon in the field. Still remember when I bought his book early in my career. One my fave pics is this one that captured a moment when he stood up to ask a ? after my talk. Very cool. #BigFan

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

Day 1, #kidneywk 25, We attended the poster presentation, which focused on an important topic: Reducing gaps and strengthening training in urinary sediment analysis. We were joined by someone passionate about U-sed. @juancarlosqvelez.bsky.social , @roxnonna23.bsky.social .

Problem here is - especially in places like ours (India), affordability remains a problem - with the amount they spend on a biopsy they could afford 6 months of non immune therapy - so our biopsies are probably- At diagnosis and then only when absolutely indicated

#NephJC

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC

www.nephjc.com/news/...

2025 IgAN KDIGO guidelines: fresh out of press, already aging gracefully — NephJC This week, we will discuss the 2025 KDIGO IgAN guidelines. which the shift from supportive care to structured, evidence-based therapy

The 2025 @kdigo.org IgAN guideline quietly redraws the map: new drugs, new thresholds, and a sense that the era of “supportive care only” is finally over #Nephsky #Medsky

✍️Summary by @thekidneywhisperer.bsky.social and
@glomerican.bsky.social

www.nephjc.com/news/igan-kd...

KDIGO 2025 IgA guidelines - Visual Abstract — NephJC KDIGO 2025 is here. IgAN management is evolving with precision risk tools, new therapies, and a stronger focus on kidney protection. Check out the visual abstract created by Natalia Nombera

⏩ Next #NephJC is on IgA nephropathy @kdigo.org guideline

🎨 Nice visual summary by @roxnonna23.bsky.social

www.nephjc.com/news/2025/10...

Guías KDIGO 2025 IgA - El Resumen Visual — NephJC Las guías KDIGO 2025 están aquí. El manejo de la nefropatía por IgA (NIgA) está evolucionando con herramientas de estratificación de riesgo más precisas, nuevas terapias y un enfoque más sólido en la ...

El próximo #NephJC se centra en la guía de nefropatía por IgA.

🎨 Buen resumen visual de @roxnonna23.bsky.social

🌐 Traducido por @dramiliflores.bsky.social

www.nephjc.com/news/2025/10...

Great chat Saivani 🤩

Fascinating finding: many patients lost chimerism but stayed IS-free. 🤔 This suggests chimerism is a transient 'switch' to turn on tolerance, not the long-term mechanism itself. We urgently need to identify that mechanism for safer weaning protocols. #NephJC