Bryce Manso, Ph.D.

We have packed a ton into this paper, so please enjoy and reach out with any questions!
A HUGE thank you to all the collaborators and funding sources for making this happen!

We also demonstrate that both intrinsic and extrinsic effects contribute to informating HSCs to take this pathway, and that MkPs generated via this path uniquely possess a survival advantage!

Here, we add to and clarify a number of new findings in the world of #megakaryopoiesis at steady-state and during aging, including officially revealing the ability to identify HSC-direct, age-dependent MkPs without the need of a lineage tracing model!

A Rare Hematopoietic Stem Cell‐Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging Manso et al. developed strategies for isolating and testing the functional mechanisms regulating age-specific megakaryocyte progenitors derived from hematopoietic stem cells.

A little late, but 🚨new paper alert!🚨
Interested in #aging, #blood, #StemCells, #HSCs, #platelets, or #MkPs? Read on!
onlinelibrary.wiley.com/doi/10.1111/...

No notes

Bribery in 'plane' sight?
Jokes aside...this is disgusting

Hey #hematopoiesis / #StemCell / #Immunology / #Laboratory people (any field!) Looking for an exceptionally talented and dedicated junior specialist/associate/technician? Have I got the person for you!! They are open to moving anywhere in the US or internationally! DM for details/contact. Please RT!

PhD Timeline xkcd.com/3081

For an act to be evil, does it have to be intentional? Or can (willful?) ignorance that results in a harmful act still be considered evil?
Asking for a friend (the US is the friend) #iykyk

So, spam/predatory/scam messages for papers, conferences, speaking engagements, etc. are pretty common, but today I finally got the one I've always wanted! The good 'ol 'Dear Dr. FirstName'

As federal funding for research is uncertain, we need to diversify funding sources for our PhD students.

Here is a comprehensive list of >160 PhD fellowships and funding opportunities, mostly from private foundations and scientific societies.

Download it here: research.jhu.edu/rdt/funding-...

Can't attend any Stand Up for Science (@standupforscience.bsky.social) events today due to family obligations, but my heart, soul, and passion is with you all! #Science is a major cornerstone of our global, national, and local communities. Rally the masses and be seen, heard, and not ignored!

this might help:

bsky.app/profile/prof...

Woke up to an email from the #NIH saying that my K22 Summary Statement was available! Super exciting! To my dismay, the NIH websites (nearly ALL of them) have been down all day. Not normal. Others see the same, with no reason given. Hopefully nothing important, but given everything...not too hopeful

Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

The Termini Lab at Fred Hutch in Seattle is recruiting a Lab Aide to join our group - more information and instructions to apply can be found at the posting below 👇🧫👇🔬👇🐁
careers-fhcrc.icims.com/jobs/29265/l...

PSA: 10X will discontinue the GEM Kits (3', 5' and Flex) at the end of the year, in case you want to get one in storage for paper revisions

Hostelling*

While the US Federal government continues their heinous attacks against DEI, I am so happy to be staying at a Hosteling International property!

This is such a cool idea! Consider myself volunteered!

I’m with Denmark.

Tornadoes in California? In Santa Cruz County? Yep, Scott’s Valley got hit relatively hard with a few injuries

A rare HSC-derived megakaryocyte progenitor accumulates via enhanced survival and contributes to exacerbated thrombopoiesis upon aging Distinct routes of cellular production from hematopoietic stem cells (HSCs) have defined our current view of hematopoiesis. Recently, we challenged classical views of platelet generation, demonstratin...

Full link to the text:
www.biorxiv.org/content/10.1...

As if my #ASH24 FOMO wasn't enough already, they go and do this!

The dynamics of hematopoiesis over the human lifespan - Nature Methods This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC.
www.nature.com/articles/s41...

(7/7)...Finally, environment may be the "missing link" to this age-unique pathway, but more on that soon......
Please do give it a read and let us know what you think! We are excited to share this story!

(6/7)...In fact - young non-canonical (nc)MkPs do come from HSCs, but not directly, yet may bypass other myeloid progenitors. #Aged HSCs can directly give rise to ncMkPs (as we have previously shown), but not in a clonally-restricted fashion...

(5/7)...we find a rare yet unique population of these MkPs in young mice 🤯. Others have suggested this too, but we find some unique functions and challenge the current ideas of their onteogeny....

(4/7)...including identifying #CD48 as a unique identifier of heterogenous #MkP s. Together with another marker (you'll have to read the manuscript!), we prospectively identify age-unique populations of MkPs without needing a special mouse model! SURPRISINGLY....

(3/7) First, we followed up on our paradigm-shifting findings in @cellcellpress.bsky.social
(tinyurl.com/52u5fsfk) by diving deep into the age-unique platelet specification pathway (#megakaryopoiesis) using #CITEseq and a number of other approaches...

(2/7) First, a HUGE thank you to the co-authors - check out their work too!
(Authors please retweet with your bsky handle if you'd like!).