Merve Nur Güler

Bias in genome-wide association test statistics due to omitted interactions Over the past two decades, genome-wide association studies (GWAS) enabled the discovery of thousands of variants associated with many complex human traits. However, conventional GWAS are still widely ...

In our new study, we investigate how GWAS test statistics behave when a trait’s genetic architecture includes epistasis. We first model the bias mathematically and show via simulations how linear models can produce spurious significance (more in comments).
www.biorxiv.org/content/10.1...

YouTube video by Merve Nur Güler The Code

Huge thanks to the University of Tartu Institute of Genomics and Eesti Geenikeskus for giving me this opportunity.

Watch my video "The Code" and share your thoughts!

The theme was “Human and Artificial Intelligence in Science in 2035”. Creating this video and participating in the Gene Forum was such an educational and inspiring experience. I’m already excited for the 25th Gene Forum next year!

I am happy and honoured to share that I won the Grand Prize in the Artur Lind Scholarship video competition at the Gene Forum 2025. 🎉

DeepKin: Predicting Relatedness From Low‐Coverage Genomes and Palaeogenomes With Convolutional Neural Networks DeepKin is a novel tool designed to predict relatedness from genomic data using convolutional neural networks (CNNs). Traditional methods for estimating relatedness often struggle when genomic data i...

Our genetic kinship estimation tool “DeepKin” is now available! Our neural network models trained on simulated data work effectively on real ancient data from diverse backgrounds and often outperform available tools. @compevohumang.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Using 130 ancient genomes, we uncover shifting community structures -> moving from family-based to more communal households, with practices favoring female lineages.
🧬🏺 #ancientDNA #Çatalhöyük #archaeogenetics #Neolithic

Female lineages and changing kinship patterns in Neolithic Çatalhöyük Combining 131 paleogenomes with bioarchaeological and archaeological data, we studied social organization and gendered practices in Çatalhöyük East Mound (7100 to 5950 BCE), a major Neolithic settleme...

Happy to share our new study I contributed to during my master’s: "Female lineages and changing kinship patterns in Neolithic Çatalhöyük." @compevohumang.bsky.social

The Estonian Biobank’s journey from biobanking to personalized medicine - Nature Communications Large-scale biobanks have become a font of data that have led to discoveries across many fields of research. Here, the authors provide an overview of the Estonian Biobank, highlighting its value for r...

Excited to share our recently published overview of the @estbiobank.bsky.social 🧬
We highlight the unique features of the biobank and the conducted scientific research it has enabled, including the many recall studies that have been carried out over the years!
www.nature.com/articles/s41...