Isaac Garcia Bosch

My department is searching for two tenure-line positions to start in August 2026. Come join our growing team and make a difference in building the future!

Assistant professor of higher education: apply.interfolio.com/172680

Associate/full professor of education policy: apply.interfolio.com/172632

Million-Fold Activation of C¬H Bonds by Fluorinated Non-heme FeIV=O Complexes via Second Sphere Equatorial Sub-stitution and Catalytic Epoxidation to Boot FeIV=O units found in the active sites of nonheme iron oxygenases and related synthetic analogs are intriguing inter-mediates capable of performing challenging oxygenation reactions. The first crystal...

This @chemrxiv.org contribution is soon coming to come to a journal near to you

doi.org/10.26434/che...

Skeletal editing: How close are we to true cut-and-paste chemistry? Reactions that alter organic scaffolds by a single atom are already proving useful, but time will tell if they’ll fundamentally change how molecules are made

Less than a decade ago, reactions for adding, deleting, and swapping single atoms in complex organic molecules were almost unheard of. Now there’s a growing community of researchers working on them. cen.acs.org/synthesis/Sk... #chemsky 🧪

Intramolecular Oxo Atom Migration to the cis Thiolate Sulfur of an Fe-Oxo Intermediate Herein, we show for the first time that thiolate ligands can play an important role in promoting 2e- oxo atom transfer with nonheme iron. We examine the mechanism of oxo atom transfer to a cis thiolate sulfur for two structurally related iron complexes using low-temperature kinetics, spectroscopic, and computational methods. Intermediate oxo atom donor adducts, FeOIAr, are spectroscopically characterized and shown to have electronic spectral, EPR, and Mössbauer parameters, and kinetic barriers dependent on the nature of the oxo atom donor. More stable adducts containing pyridine N-oxide (PNO) were crystallographically characterized and computationally optimized to establish optimum functionals and basis sets. Oxo atom transfer is shown both experimentally and computationally to involve a stepwise, as opposed to a concerted, mechanism. A new metastable intermediate is observed by low-temperature Mössbauer and ⊥-mode EPR after the Fe–OxIPh intermediate and prior to the final sulfenate Fe-OSR product. The DFT calculated minimum energy pathway is shown to contain a local minimum between the Fe–O2IPh adduct and Fe–S(R)O product. The DFT optimized geometric and electronic structure of this intermediate is shown to be consistent with an S = 1 Fe(IV)═O that is antiferromagnetically coupled to an S = 1/2 radical delocalized over the two cis thiolate-sulfurs, analogous to the electronic configuration of P450 Cmpd I. Radical character on the thiolate sulfur adjacent to the oxo is shown to facilitate trapping of the high-valent Fe-oxo as a η2-SO-Fe sulfenate complex.

Congratulations to Maike, Deesha, Shilpa , and Haley on a fantastic piece of work!! You guys are amazing!! University of Washington pubs.acs.org/doi/10.1021/...

Silicon-based ‘ladder molecules’ take a step up in complexity New compounds are 'among the most complex organosilanes ever synthesised'

Ladder molecules just got more complex, with a series of compounds featuring fused six-membered silicon rings, created by reacting a silicon dianion with a tetrasubstituted cyclohexasilane ring. #ChemSky

34C, 34F or 34K??? Hahaha

Prof. Alex Guo, Guo lab postdoc Dr. Jin Xiong, and their collaborators have received the Royal Society of Chemistry's 2025 Dalton Horizon Prize! 🥳🎉🎊🙌🥂

www.cmu.edu/mcs/news-eve...

www.rsc.org/standards-an...

Així sí. Coca de crema de pastisseria Puigdemont. Visca Catalunya Independent!

NYT, Page One:

“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”

@nytimes.com

In Lund, visiting and presenting some research on Cu-promoted C-H hydroxylation reactions... I love this city!!!! 😍😍😍

Synthesis and Characterization of Copper Complexes Featuring a Redox-Active ONO Ligand in Three Molecular Oxidation States In this research article, we report the synthesis, characterization, and reactivity of a family of Cu complexes bearing a tridentate iminosemiquinone ligand and ancillary amine ligands ((sqONO)CuII(L)...

Latest cu-rious paper is now online

pubs.acs.org/doi/10.1021/...

With the @isaacgb9.bsky.social lab

#chemsky

Synthesis and Characterization of Copper Complexes Featuring a Redox-Active ONO Ligand in Three Molecular Oxidation States | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Swart, Garcia-Bosch, and co-workers @InorgChem #cupper #ONO #redoxactive #catechol #amines #reactivity

I have some bittersweet news: I won't be starting my faculty career in the Chemical Engineering Department at Carnegie Mellon University. Come Sept., I will be joining the School of Chemistry at @ucddublin.bsky.social as an Ad Astra Fellow and Asst. Prof. of "digital chemistry".

#ChemSky #CompChem

Direct Evidence for Buffer-Enhanced Proton-Coupled Electron Transfer Generation of a High-Valent Metal-Oxo Complex | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Meyer and co-workers @InorgChem #ruthenium #PCET #oxo #buffer_enanced #concerted #ITO #catalysis

The 2025 gathering of molecular machinists is nearly here! Interested in single molecule walkers, motors, or ratchets? Curious how molecular machines our transforming emergent materials? Want to organize with like minded scientists?

Its not too late to join us 🧪

Apply by May 25
Register by June 1

Identification of Chlorinated Alkyl Ethoxylate Surfactants in Produced Water from the Marcellus Region and Proposed Subsurface Formation Mechanism Wastewater produced from hydraulic fracturing of unconventional oil and gas wells is a complex mixture of high levels of salts and variable levels of organics, naturally occurring radioactive material...

pubs.acs.org/doi/10.1021/... 😍

W1 Professorship (with W2 tenure track) in Theoretical Chemistry

#ChemJobs Theoretical chemistry (W1, tenure track) Giessen (DE)

www.uni-giessen.de/de/ueber-uns...

Deadline: June 26, 2025

#CompChem #ChemSky

Seeing an Unobservable Fe(III)/Fe(IV) Redox Process of the Nonheme Iron N4Py Complex by High-Speed Surface-Enhanced Raman Spectroelectrochemistry | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Browne & co-workers @InorgChem #iron #III #IV #nonheme #N4Py #highspeed #SER #spectro_ec

Yikes

Characterization of Three Intermediates in an Unusual Copper-Dependent Enzyme Three intermediates in the formylglycine-generating enzyme are characterized at the molecular level.

The #FirstReaction by @isaacgb9.bsky.social and me on the paper by @carolynbertozzi.bskyverified.social, Ed Solomon and co-workers (doi.org/10.1021/acsc...) is now online in @pubs.acs.org ACS Cent Sci:
doi.org/10.1021/acsc...

Two SCS Students Awarded Goldwater Scholarships SCS undergrads Sheng Shu and Hyojae Park have received 2025 Goldwater Scholarships.

Congratulations to junior Sheng Shu on receiving a Goldwater Scholarship. Shu is majoring in computer science and also studying chemistry in our undergraduate program.

Shu has worked in the labs of faculty members @isaacgb9.bsky.social and @olexandr.bsky.social

www.cs.cmu.edu/news/2025/go...

DOGE’s orders threaten NSF grants and proposals Already-approved grants were sent back for review, while 200 active ones may face termination

NSF announced that it has begun terminating awards. It's unclear how many affected. Sources say it could be over 200

It's also re-reviewing proposals that had already been approved for funding

Here's a breakdown of what's happened this week: cen.acs.org/policy/resea...

#ChemSky #Science

Science and engineering students are hit as US revokes visas Unclear how many chemistry students have been affected by ‘brand-new . . . scary era’

A graduate student in chemical engineering at North Carolina State University is one of an uncertain but growing number of international students in the US on visas that Immigration and Customs Enforcement (ICE) has abruptly revoked. cen.acs.org/policy/Scien... 🧪 #chemsky #phdsky #academicsky

Chinese Students on U.S. Campuses Are Ensnared in Political Standoff Some say their visas were revoked this week; Beijing warns other nationals to reconsider study plans in America.

The Chinese government just advised the 250,000 Chinese students attending US colleges to reconsider their decision. That's a big deal for many selective public and private universities that rely on them as a revenue and talent source.

🔴🔵❤️❤️❤️

Wow!!! 😊

chemsky 🧪⚗️

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...

One thing you can count on from me is to share great synthesis. While we may be competitors, I’ll highlight this review of #MerckChemistry innovations in #JOCasap from my respected industry colleague and friend @drlcsquare.bsky.social The work here is inspiring and drives us to our best #ChemSky

Easy for me to predict - this is what next cycle's Faculty Jobs List is going to look like as well

Check out our new paper in Chem. Sci. Bimetallic cleavage of N2 gives very stable nitrides, with little driving force to add an H atom or H+/e- to get to ammonia. But the catalysts find a way around that problem... Great work by
@souvikm.bsky.social and many others! doi.org/10.1039/D5SC...